ChemicalBook > CAS DataBase List > N-Boc-piperazine-2-carboxylic acid methyl ester

N-Boc-piperazine-2-carboxylic acid methyl ester

Product Name
N-Boc-piperazine-2-carboxylic acid methyl ester
CAS No.
129799-15-1
Chemical Name
N-Boc-piperazine-2-carboxylic acid methyl ester
Synonyms
Piperazine-1,2-dicarb;Methyl 1-Boc-2-piperazinecarboxylate;METHYL 1-BOC-PIPERAZINE-2-CARBOXYLATE;N-Boc-piperazine-2-carboxylic acid methyl ester;1-Boc-piperazine-2-carboxylic acid methyl ester;1-N-BOC-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER;N-1-BOC-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER;1-Boc-2-Piperazinecarboxylic acid methyl ester;1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER;1-tert-Butyl 2-Methyl piperazine-1,2-dicarboxylate
CBNumber
CB8683676
Molecular Formula
C11H20N2O4
Formula Weight
244.29
MOL File
129799-15-1.mol
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N-Boc-piperazine-2-carboxylic acid methyl ester Property

Boiling point:
321.3±37.0 °C(Predicted)
Density 
1.118g/ml
storage temp. 
2-8°C(protect from light)
form 
gel/ oil
pka
7.25±0.40(Predicted)
color 
Yellow
optical activity
-2.9800° (C=0.50 g/100ml, MEOH, 20°C, 589nm)
InChI
InChI=1S/C11H20N2O4/c1-11(2,3)17-10(15)13-6-5-12-7-8(13)9(14)16-4/h8,12H,5-7H2,1-4H3
InChIKey
BRXKHIPPSTYCKO-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCNCC1C(OC)=O
CAS DataBase Reference
129799-15-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43-41-37/38
Safety Statements 
26-36/37/39
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B812450
Product name
1-tert-Butyl2-methylpiperazine-1,2-dicarboxylate
Packaging
500mg
Price
$60
Updated
2021/12/16
TRC
Product number
B812450
Product name
1-tert-Butyl2-methylpiperazine-1,2-dicarboxylate
Packaging
1g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
073556
Product name
1-tert-Butyl 2-methyl piperazine-1,2-dicarboxylate
Purity
95+%
Packaging
1g
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB44253
Product name
N-1-Boc-2-Piperazinecarboxylic acid methyl ester
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB44253
Product name
N-1-Boc-2-Piperazinecarboxylic acid methyl ester
Packaging
1g
Price
$100
Updated
2021/12/16
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N-Boc-piperazine-2-carboxylic acid methyl ester Chemical Properties,Usage,Production

Uses

1-tert-Butyl 2-methyl piperazine-1,2-dicarboxylate is a useful research chemical compound used in the preparation of piperazinylcarbonylaminomethylcarbonylpiperidines as melanocortin-4 receptor agonists.

Synthesis

129799-14-0

129799-15-1

The general procedure for the synthesis of methyl N-1-Boc-2-piperazinecarboxylate from 4-benzyl 1-tert-butyl 2-methylpiperazine-1,2,4-tricarboxylate is as follows: Example 53 - Preparation of Intermediate 18: The synthesis of Intermediate 18 followed General Procedure 14. To a solution of Intermediate 17 (1-benzyl stirred solution of 4-benzyl 1-methylpiperazine-1,2,4-tricarboxylic acid, 10 g, 26.5 mmol) in MeOH (100 mL) was added 10% Pd/C (30% w/w, 3.0 g). The mixture was placed in a steel vessel and stirred at room temperature under 50 psi hydrogen pressure for 5 hours. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the volatiles were concentrated under reduced pressure to afford 1-tert-butyl 2-methylpiperazine-1,2-dicarboxylate (Intermediate 18, 5.6 g, Yield: 88%) as a light yellow liquid.TLC conditions: 5% methanol-dichloromethane, Rf=0.3.

References

[1] Patent: WO2016/138532, 2016, A1. Location in patent: Paragraph 0288
[2] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 47
[3] Patent: US4997836, 1991, A
[4] Patent: EP368670, 1990, A1
[5] Patent: US2004/116518, 2004, A1. Location in patent: Page 42

N-Boc-piperazine-2-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Boc-piperazine-2-carboxylic acid methyl ester manufacturers

Career Henan Chemical Co
Product
N-Boc-piperazine-2-carboxylic acid methyl ester 129799-15-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000Kgs
Release date
2019-12-25

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  • METHYL 1-BOC-PIPERAZINE-2-CARBOXYLATE
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