4-formyl-3-methoxybenzonitrile

Product Name: 4-formyl-3-methoxybenzonitrile
CAS No.: 21962-45-8
Chemical Name: 4-formyl-3-methoxybenzonitrile
Synonyms: 4-forMyl-3-Methoxybenzonitrile;4-Cyaon-2-methoxybenzaldehyde;Finerenone Impurity 111;2-Methoxy-4-cyanobenzaldehyde;4-CYANO-2-METHOXYBENZALDEHYDE;4-Cyan0-2-methoxybenzaldehyde;4-Formyl-3-methoxybenzonitril;3-Formyl-3-methoxybenzonitrile;Benzonitrile, 4-formyl-3-methoxy-;Para-tert-Butyl Benzene Sulfonamide
CBNumber: CB8684633
Molecular Formula: C9H7NO2
Formula Weight: 161.16
MOL File: 21962-45-8.mol

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4-formyl-3-methoxybenzonitrile Property

Melting point:: 109-111℃
Boiling point:: 318℃
Density: 1.18
vapor pressure: 0.003-2.3Pa at 20-80℃
Flash point:: 138℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
InChI: InChI=1S/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3
InChIKey: ZXENVSJZOHXCKL-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=C(C=O)C(OC)=C1
LogP: 1.42 at 20℃ and pH7

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C998488
Product name: 4-Cyano-2-methoxybenzaldehyde
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J98031
Product name: 4-Cyano-2-methoxybenzaldehyde
Packaging: 5g
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: X2725
Product name: 4-Cyano-2-methoxybenzaldehyde
Packaging: 25g
Price: $374
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0150549
Product name: 4-CYANO-2-METHOXYBENZALDEHYDE
Purity: 95.00%
Packaging: 5MG
Price: $500.81
Updated: 2021/12/16

Ambeed

Product number: A206573
Product name: 4-Formyl-3-methoxybenzonitrile
Purity: 98%
Packaging: 250mg
Price: $10
Updated: 2021/12/16

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4-formyl-3-methoxybenzonitrile Chemical Properties,Usage,Production

Uses

4-formyl-3-methoxybenzonitrile is a Finerenone intermediate compound. Finerenone is a non-steroidal salicorticosteroid receptor antagonist used to reduce the risk of serious kidney and heart problems in patients with chronic kidney disease associated with type 2 diabetes.

Synthesis

79 g (370 mmol) of sodium metaperiodate are added in portions to a vigorously stirred solution of 48 g (185 mmol) of tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate, 207 mg (0.81 mmol) of osmium tetroxide and 1.4 g (6.14 mmol) of benzyltriethylammonium chloride in 750 ml of water/THF (2:1), keeping the reaction temperature below 30° C. The solution is stirred at RT for a further 1 h. Water (2000 ml) is added, and the mixture is filtered. The remaining solid is dissolved in ethyl acetate and washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is stirred with petroleum ether. 21.18 g (71% of theory) of 4-cyano-2-methoxybenzaldehyde (4-formyl-3-methoxybenzonitrile) is obtained as a white solid.

4-formyl-3-methoxybenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-formyl-3-methoxybenzonitrile Suppliers

China 286 India 13 United Kingdom 4 United States 10 Global 313

Accela ChemBio Inc.

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Biogene Organics Inc.

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View Lastest Price from 4-formyl-3-methoxybenzonitrile manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: 4-CYANO-2-METHOXYBENZALDEHYDE 21962-45-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0
Supply Ability: 2000
Release date: 2023-11-06

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: 4-Cyano-2-methoxybenzaldehyde 21962-45-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ≥98% by HPLC
Supply Ability: 100kg/month
Release date: 2023-01-05

Cangzhou Kangrui Pharma Tech Co. Ltd.,

Product: 4-Cyano-2-methoxybenzaldehyde 21962-45-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 150kgs
Release date: 2024-12-02

21962-45-8, 4-formyl-3-methoxybenzonitrileRelated Search:

4-Cyano-2-methoxyphenylboronic acid 4-tert-Butylbenzaldehyde 2-CYANO-4-METHOXYBENZALDEHYDE Benzonitrile, 3-hydroxy-4-methyl- 6-CYANO-4-CHROMANONE 3-METHOXY-4-METHYLBENZONITRILE Benzonitrile, 4-formyl-3-hydroxy- 4-CYANO-2-METHOXYBENZALDEHYDE

4-CYANO-2-METHOXYBENZALDEHYDE

4-Cyaon-2-methoxybenzaldehyde

2-Methoxy-4-cyanobenzaldehyde

4-forMyl-3-Methoxybenzonitrile

4-ForMyl-3-Methoxybenzonitrile(2-Methoxy-4-cyanobenzaldehyde)

Benzonitrile, 4-formyl-3-methoxy-

4-Formyl-3-methoxybenzonitrile (or) 4-Cyano-2-Methoxy Benzaldehyde

4-Cyano-2-neneneba methoxy Benzaldehyde

4-Cyan0-2-methoxybenzaldehyde

4-CYANO-2-METHOXYBENZALDEHYDE,Finerenone

3-Formyl-3-methoxybenzonitrile

4-Formyl-3-methoxybenzonitril

Finerenone Impurity 111

Para-tert-Butyl Benzene Sulfonamide

21962-45-8

Intermediate

21962-45-8