4,6-Dimethylpyrimidine-5-carboxylic acid
- Product Name
- 4,6-Dimethylpyrimidine-5-carboxylic acid
- CAS No.
- 157335-93-8
- Chemical Name
- 4,6-Dimethylpyrimidine-5-carboxylic acid
- Synonyms
- 5-Carboxy-4,6-dimethylpyrimidine;4,6-Dimethylpyrimidine-5-carboxylicaci;4,6-DIMETHYLPYRIMIDINE-5-CARBOXYLIC ACID;4,6-dimethyl 5-pyrimidine carboxylic acid;5-PyriMidinecarboxylicacid, 4,6-diMethyl-;4,6-DIMETHYLPYRIMIDINE-5-CARBOXYLIC ACID ,98%;5-Pyrimidinecarboxylicacid,4,6-dimethyl-(9CI);4,6-dimethylpyrimidine-5-carboxylic acid - [D20471];4,6-Dimethylpyrimidine-5-carboxylic acid ISO 9001：2015 REACH;5-Carboxy-4,6-dimethylpyrimidine, 5-Carboxy-4,6-dimethyl-1,3-diazine
- CBNumber
- CB8691352
- Molecular Formula
- C7H8N2O2
- Formula Weight
- 152.15
- MOL File
- 157335-93-8.mol
4,6-Dimethylpyrimidine-5-carboxylic acid Property
- Boiling point:
- 319.7±37.0 °C(Predicted)
- Density
- 1.257±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.78±0.32(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 157335-93-8(CAS DataBase Reference)
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D460055
- Product name
- 4,6-Dimethylpyrimidine-5-carboxylicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR5844
- Product name
- 4,6-Dimethylpyrimidine-5-carboxylicacid
- Packaging
- 250mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 4H56-1-Q3
- Product name
- 4,6-Dimethylpyrimidine-5-carboxylic acid
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- FD11922
- Product name
- 4,6-Dimethylpyrimidine-5-carboxylic acid
- Packaging
- 250mg
- Price
- $52.5
- Updated
- 2021/12/16
- Product number
- FD11922
- Product name
- 4,6-Dimethylpyrimidine-5-carboxylic acid
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
4,6-Dimethylpyrimidine-5-carboxylic acid Chemical Properties,Usage,Production
Uses
4,6-Dimethylpyrimidine-5-carboxylic acid is a pharmaceutical intermediate compound used in the preparation of macrocyclic broad-spectrum antibiotics.
Synthesis
305794-79-0
157335-93-8
Ethyl 4,6-dimethylpyrimidine-5-carboxylate (10.9 g, 0.0605 mol) was used as starting material, which was mixed with an aqueous solution (70 mL) of sodium hydroxide (4.0 g, 0.10 mol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction solution was acidified with concentrated hydrochloric acid and subsequently the solution was concentrated to dryness. To the dried residue, acetone (100 mL) was added, the insoluble sodium chloride was removed by filtration, and the solid was washed with methanol (100 mL). The filtrate was concentrated to dryness and the resulting residue was washed with acetonitrile (ACN) to give a final 8.5 g (92% yield) of 4,6-dimethylpyrimidine-5-carboxylic acid solid product. The mass spectrum (EI) showed a m/z of 153.1 (M + 1). 1H NMR (400 MHz, CD3OD) data were as follows: δ 8.89 (s, 1H), 2.56 (s, 6H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 4, p. 709 - 712
[2] Patent: US2005/261310, 2005, A1. Location in patent: Page/Page column 1220
[3] Patent: US6391865, 2002, B1. Location in patent: Page column 86
[4] Patent: EP1175402, 2005, B1. Location in patent: Page/Page column 54
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 567 - 571
4,6-Dimethylpyrimidine-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4,6-Dimethylpyrimidine-5-carboxylic acid Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6003
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 4,6-Dimethylpyrimidine-5-carboxylic acid manufacturers
- Product
- 4,6-Dimethylpyrimidine-5-carboxylic acid 157335-93-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-06
- Product
- 4,6-Dimethylpyrimidine-5-carboxylic acid 157335-93-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-09