L-Alaninol
- Product Name
- L-Alaninol
- CAS No.
- 2749-11-3
- Chemical Name
- L-Alaninol
- Synonyms
- L-ALANINOL;2-AMINOPROPANOL;H-ALA-OL;310399;L-2-Amino-1-propanol;(S)-2-AMINO-1-PROPANOL;L-Ala-ol;L-Alanino;L-ALANILOL;H-ALANINOL
- CBNumber
- CB8693194
- Molecular Formula
- C3H9NO
- Formula Weight
- 75.11
- MOL File
- 2749-11-3.mol
L-Alaninol Property
- Melting point:
- -2°C
- Boiling point:
- 72-73 °C11 mm Hg(lit.)
- alpha
- 21.8 º (c=2,ethanol)
- Density
- 0.965 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.450
- Flash point:
- 145 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- Water Solubility
- Completely miscible in water
- solubility
- Chloroform, Methanol (Slightly)
- pka
- 12.88±0.10(Predicted)
- form
- Oily Liquid
- color
- Clear colorless to yellow
- Specific Gravity
- 0.96
- optical activity
- [α]20/D +18°, neat
- Sensitive
- Hygroscopic
- BRN
- 1718865
- CAS DataBase Reference
- 2749-11-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 1-Propanol, 2-amino-, (S)-(2749-11-3)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-36/37/38
- Safety Statements
- 26-36/37/39-45-36
- RIDADR
- UN 2735 8/PG 2
- WGK Germany
- 3
- F
- 10-23
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29221990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A76206
- Product name
- (S)-(+)-2-Amino-1-propanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $47.2
- Updated
- 2024/03/01
- Product number
- A76206
- Product name
- (S)-(+)-2-Amino-1-propanol
- Purity
- 98%
- Packaging
- 10g
- Price
- $293
- Updated
- 2024/03/01
- Product number
- A1085
- Product name
- (S)-(+)-2-Amino-1-propanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 1mL
- Price
- $28
- Updated
- 2024/03/01
- Product number
- A1085
- Product name
- (S)-(+)-2-Amino-1-propanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5mL
- Price
- $93
- Updated
- 2024/03/01
- Product number
- B24916
- Product name
- (S)-(+)-2-Amino-1-propanol, 98%
- Packaging
- 5g
- Price
- $108.65
- Updated
- 2024/03/01
L-Alaninol Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
S-(+)-2-Amino-1-propanol is an aliphatic amino alcohol shown to induce an antiproliferative effect in B16 melanoma cells. S-(+)-2-Amino-1-propanol is used in the preparation of oxazolines which are of ten used as ligands in homogeneous catalysis.
Uses
(S)-(+)-2-Amino-1-propanol (L-Alaninol) may be used in the preparation of unsymmetrical tridentate Schiff base ligands via condensation with carbonyl compounds. It may also be used as a chiral auxillary for the preparation of tert-butyl 4-N-[(2-hydroxy-1-(S)-methyl)ethylamino]-2-methylene-4-(S)-phenyl-butyrate.
Definition
ChEBI: An amino alcohol that is L-alanine in which the carboxy group has been reduced to the corresponding alcohol.
Biochem/physiol Actions
Pseudomonas sp. strain KIE171 was able to grow with L-alaninol [S-(+)-2-amino-1-propanol] as the sole carbon source[1]. W?sch et al. found that mutant KIE171-BI transformed isopropylamine to L-alaninol, mutant KIE171-BII failed to do so.
Synthesis
Simply produce L-alaninol in high yield and good reproducibility by directly reducing an inorganic acid salt of an L-alanine ester with NaBH4. 3.0 mol of NaBH 4 was added and dissolved in 560 ml of cold water, and L-alanine ethyl ester hydrochloride 1. A solution of 0 mol dissolved in 560 ml of ethanol was added. The mixture was added dropwise at 20 ° C. over 5 hours and further aged at 20 to 28 ° C. to complete the reaction. After the reaction, excess NaBH 4 was decomposed with acetone, 1000 ml of ethyl acetate was introduced, and the precipitated inorganic substance was separated by filtration. The lower aqueous layer portion of the filtrate was extracted with 600 ml of ethyl acetate; the ethyl acetate layer was distilled under reduced pressure to remove the solvent and then vacuum distilled to yield L-alaninol.
Purification Methods
Purify it as for S-2-amino-3-methylbutan-1-ol below. [Beilstein 4 IV 1615.]
References
[1] Susana I de Azevedo W?sch. “Transformation of isopropylamine to L-alaninol by Pseudomonas sp. strain KIE171 involves N-glutamylated intermediates.”Applied and Environmental Microbiology (2002): 68.
L-Alaninol Preparation Products And Raw materials
Raw materials
Preparation Products
L-Alaninol Suppliers
- Tel
- --
- Fax
- --
- r.eckert@rothsochiel.fr
- Country
- France
- ProdList
- 2361
- Advantage
- 58
- Tel
- --
- Fax
- --
- interchim@interchim.com
- Country
- France
- ProdList
- 6302
- Advantage
- 76
View Lastest Price from L-Alaninol manufacturers
- Product
- H-Ala-ol 2749-11-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-01-14
- Product
- S-(+)-2-Amino-1-propano 2749-11-3
- Price
- US $125.00/ASSAYS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2021-06-07
- Product
- L-Alaninol 2749-11-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 25kg
- Purity
- ≥98%(HPLC,min.)
- Supply Ability
- 10Tons
- Release date
- 2022-11-21