ChemicalBook > CAS DataBase List > Bilirubin

Bilirubin

Product Name
Bilirubin
CAS No.
635-65-4
Chemical Name
Bilirubin
Synonyms
Cholerythrin;BILIRUBIN MIXED ISOMERS;Biliyubin;Bilibubin;filirubin;BILIRUBIN;hemetoidin;HEMATOIDIN;1,19-dioxo-;BilirubinGr
CBNumber
CB8693422
Molecular Formula
C33H36N4O6
Formula Weight
584.66
MOL File
635-65-4.mol
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Bilirubin Property

Melting point:
192 °C
Boiling point:
641.7°C (rough estimate)
Density 
1.2163 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
-20°C
solubility 
aqueous acid: soluble
form 
powder
pka
4.62±0.10(Predicted)
color 
orange
Water Solubility 
practically insoluble
Sensitive 
Light Sensitive
Merck 
14,1218
BRN 
74376
Stability:
Stable. Refrigerate.
EPA Substance Registry System
Bilirubin (635-65-4)
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Safety

Hazard Codes 
Xn
Risk Statements 
62-36/37/38-20/21/22
Safety Statements 
22-24/25-36-26
WGK Germany 
2
RTECS 
DU3038000
F 
8
TSCA 
Yes
HS Code 
29339990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B4126
Product name
Bilirubin
Purity
≥98% (EmM/453 = 60), powder
Packaging
1g
Price
$393
Updated
2025/07/31
Sigma-Aldrich
Product number
NIST916B
Product name
Bilirubin
Purity
NIST?SRM?
Packaging
100mg
Price
$1060
Updated
2025/07/31
Sigma-Aldrich
Product number
B4126
Product name
Bilirubin
Purity
≥98% (EmM/453 = 60), powder
Packaging
5g
Price
$1460
Updated
2025/07/31
Sigma-Aldrich
Product number
2011
Product name
Bilirubin - CAS 635-65-4 - Calbiochem
Purity
Principal pigment of bile and one of the major end products of hemoglobin decomposition.
Packaging
1g
Price
$258
Updated
2025/07/31
Sigma-Aldrich
Product number
14370
Product name
Bilirubin
Purity
purum, ≥95.0% (UV)
Packaging
1 g
Price
$389
Updated
2025/07/31
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Bilirubin Chemical Properties,Usage,Production

Description

Bilirubin is a yellow breakdown product of heme catabolism, formed when heme is cleaved by heme oxygenase. This reaction produces carbon monoxide and biliverdin, which is rapidly reduced to bilirubin by biliverdin reductase. Bilirubin has key roles as a free radical scavenger with antioxidant and anti-inflammatory actions. Free and albumin-bound bilirubin can also scavenge nitric oxide (NO) and NO-related species. Unconjugated bilirubin is highly water-insoluble and must be conjugated with glucuronides to become water soluble and subsequently excreted by the liver and kidney.

Chemical Properties

Light Orange to Deep Redish-Brown Crystalline Solid

Uses

Principal pigment of bile and constituent of many biliary calculi

Uses

Bilirubin is widely utilized to monitor the liver function and their disease, such as hepatitis or cirrhosis; or the effects of medicines which are damage the liver. It acts as a pigment in certain algae to capture light energy. Its double bonds are isomerizes in the presence of light, which is employed in phototherapy of jaundiced newborns babies. It is used to detect the blocking in bile ducts.

Uses

Bilirubin has been used:

  • in phantom preparation
  • in in vitro experiments
  • in the preparation of bilirubin solutions for infusion

Definition

Red coloring matter of bile. Also occurs in blood serum as decomposition product of hemoglobin.

General Description

Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.

Biochem/physiol Actions

Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher. This bile pigment has both antioxidant and toxic properties. It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs). It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases. Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease. It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.

Purification Methods

An acyclic tetrapyrrole bile pigment with impurities which can be eliminated by successive Soxhlet extraction with diethyl ether and MeOH. It crystallises from CHCl3 as deep red-brown rhombs, plates or orange-red prisms from chlorobenzene (m 330o dec) and is dried to constant weight at 80o under vacuum. [Gray et al. J Chem Soc 2264, 2276 1961, Beilstein 26 III/IV 3268.]

References

[1] DAVID G LEVITT  Michael D L. Quantitative assessment of the multiple processes responsible for bilirubin homeostasis in health and disease.[J]. Clinical and Experimental Gastroenterology, 2014, 7: 307-328. DOI: 10.2147/ceg.s64283

Bilirubin Preparation Products And Raw materials

Raw materials

Calcium chloride solution 36-40%, (1box=27kgs) BILIVERDIN DIHYDROCHLORIDE Hexanoyl chloride B12 VITAMIN B12 Glycine Chloroform Carbon disulfide Benzotrichloride L-Histidine D-Alanine Sodium metabisulfite

Preparation Products

Hyodeoxycholic acid Atificial Cow-bezoar
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View Lastest Price from Bilirubin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Bilirubin 635-65-4
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
10 KGS
Release date
2021-06-10
Hebei Chuanghai Biotechnology Co., Ltd
Product
Bilirubin 635-65-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-25
HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD
Product
Bilirubin 635-65-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50
Release date
2024-11-08

635-65-4, BilirubinRelated Search:

BILIRUBIN OXIDASE,BILIRUBIN: OXYGEN OXIDOREDUCTASE,BILIRUBIN OXIDASE, FROM MYROTHECIUM SP. Bilirubin DEEP RED BILIRUBIN DIMETHYL ESTER Bilirubin Di-acyl--D-glucuronide,Bilirubin IXα glucronide,Bilirubin IXαdiglucuronide,Bilirubin glucuronide Bilirubin Acyl--D-glucuronide(Mixture of Monoglucuronides) Bilirbin paper BILIRUBIN REFERENCE Fouchet's Reagent for Bilirubin in Urine TOTAL BILIRUBIN REAGENT, CUSTOM PACK DIRECT BILIRUBIN DILUENT TOTAL BILIRUBIN REAGENT BILIRUBIN KIT TOTAL BILIRUBIN DILUENT ANTI-BILIRUBIN OXIDASE, PEROXIDASE,ANTI-BILIRUBIN OXIDASE, MYROTHECIUM VERRUCARIA, HRP BILIRUBIN, TOTAL DIAGNOSTIC REAGENT BILIRUBIN STANDARD SET ANTI-BILIRUBIN OXIDASE, MYROTHECIUM VERRUCARIA, BIOTIN,ANTI-BILIRUBIN OXIDASE, BIOTIN Indirect Bilirubin

  • 1，10，19，22，23，24-hexahydro-2，7，13，17-tetramethyl-1，19-dioxo-3，18-divinylbilidiene-8，12-dipropionic acid
  • (Z,Z)-Bilirubin
  • Biline-8,12-dipropionic acid, 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-
  • Cholerythrin
  • Bilirubin,99%
  • Bilirubin, synthesis grade
  • Bilibubin
  • Biliyubin
  • Bilirubin, 99% 1GR
  • Bilirubin, 99% 500MG
  • 12-dipropanoicacid,2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8
  • 18-divinyl-19-dioxo-3
  • 21h-biline-8,12-dipropanoicacid,2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7
  • bilirubinix-alpha
  • 1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-
  • 1,19-dioxo-
  • 21H-Biline-8,12-dipropanoicacid,2,17-diethenyl-
  • BILIRUBIN extrapure AR
  • 3-[2-[[3-(2-carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-2-pyrrolylidene)methyl]-4-methyl-3H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-2-pyrrolylidene)methyl]-4-methyl-3H-pyrrol-3-yl]propanoic ac
  • ,13,18-tetramethyl-1,19-dioxo-
  • 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-biline-12-dipropionicacid
  • Bilirubin - CAS 635-65-4 - Calbiochem
  • hemetoidin
  • principalbilepigment
  • BILIRUBIN CALIBRATOR, TOTAL & DIRECT
  • BILIRUBIN CONTROL, TOTAL AND DIRECT*ELEVATED
  • BILIRUBIN LIN-TROL TOTAL & DIRECT
  • BILIRUBIN MIXED ISOMERS
  • BILIRUBIN STANDARD
  • BILIRUBIN CONTROL, TOTAL AND DIRECT*NORMAL
  • BILIRUBIN LIN-TROL PREDILUTED SET
  • BILIRUBIN: 21H-BILINE-8,12-DIPROPANOICACID,2,17-DIETHENYL-1,10,19,22,23,24-HEXAHYDRO-3,7,13,18-TETRAMETHYL-1,19-DIOXO-,
  • D-BiotinForBiochemistry(VitaminH)
  • BilirubinGr
  • Bilirubin,97%
  • 2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetrametyl-1,19-dioxo-21H-biline-8,12-dipropanoic Acid
  • Bilirubin IXa
  • 21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-
  • 3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
  • filirubin
  • 12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8
  • BILIRUBIN REAGENT-GRADE
  • Bilirubin from Porcine
  • 3-{2-({3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylid
  • Obeticholic Acid2
  • HEMATOIDIN
  • BILIRUBIN (EX PIG)
  • BILIRUBIN
  • BILIRUBIN (ALPHA)
  • 21H-BILINE-8,12-DIPROPANOIC ACID,2,17-DIETHENYL-1,10,19,22,23,24-HEXAHYDRO-3,7,13,18-TETRAMETHYL-1,19-DIOXO-
  • 2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid
  • Indirect bilirubin
  • Bilirubin USP/EP/BP
  • 3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((Z)-(3-methyl-5-oxo-4-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((Z)-(4-methyl-5-oxo-3-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
  • Bilirubin, GR 99%+
  • bilirubin?powder
  • 3- (2- (3- (2-carboxyethyl) -4-methyl-5- ((Z) - (3-methyl-5-oxy-4-vinyl-1H-pyrrole-2 (5H) - subunit) methyl) -1H-pyrrole-2-yl) methyl) -4-methyl-5- (Z) - (4-methyl-5-oxy-3-vinyl-1H-pyrrole-2 (5H) - subunit) methyl) -1H-pyrrole-3-yl) propionic acid
  • Bilirubin Impurity