Bilirubin

Product Name: Bilirubin
CAS No.: 635-65-4
Chemical Name: Bilirubin
Synonyms: Cholerythrin;BILIRUBIN MIXED ISOMERS;Biliyubin;Bilibubin;filirubin;BILIRUBIN;hemetoidin;HEMATOIDIN;1,19-dioxo-;BilirubinGr
CBNumber: CB8693422
Molecular Formula: C33H36N4O6
Formula Weight: 584.66
MOL File: 635-65-4.mol

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Bilirubin Property

Melting point:: 192 °C
Boiling point:: 641.7°C (rough estimate)
Density: 1.2163 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: -20°C
solubility: aqueous acid: soluble
form: powder
pka: 4.62±0.10(Predicted)
color: orange
Water Solubility: practically insoluble
Sensitive: Light Sensitive
Merck: 14,1218
BRN: 74376
Stability:: Stable. Refrigerate.
EPA Substance Registry System: Bilirubin (635-65-4)

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Safety

Hazard Codes: Xn
Risk Statements: 62-36/37/38-20/21/22
Safety Statements: 22-24/25-36-26
WGK Germany: 2
RTECS: DU3038000
F: 8
TSCA: Yes
HS Code: 29339990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B4126
Product name: Bilirubin
Purity: ≥98% (EmM/453 = 60), powder
Packaging: 1g
Price: $383
Updated: 2024/03/01

Sigma-Aldrich

Product number: B4126
Product name: Bilirubin
Purity: ≥98% (EmM/453 = 60), powder
Packaging: 5g
Price: $1360
Updated: 2024/03/01

Sigma-Aldrich

Product number: 2011
Product name: Bilirubin - CAS 635-65-4 - Calbiochem
Purity: Principal pigment of bile and one of the major end products of hemoglobin decomposition.
Packaging: 1g
Price: $251
Updated: 2024/03/01

Alfa Aesar

Product number: A17522
Product name: Bilirubin 97%
Packaging: 1g
Price: $172
Updated: 2023/06/20

Alfa Aesar

Product number: A17522
Product name: Bilirubin 97%
Packaging: 5g
Price: $638
Updated: 2023/06/20

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Bilirubin Chemical Properties,Usage,Production

Description

Bilirubin is a yellow breakdown product of heme catabolism, formed when heme is cleaved by heme oxygenase. This reaction produces carbon monoxide and biliverdin, which is rapidly reduced to bilirubin by biliverdin reductase. Bilirubin has key roles as a free radical scavenger with antioxidant and anti-inflammatory actions. Free and albumin-bound bilirubin can also scavenge nitric oxide (NO) and NO-related species. Unconjugated bilirubin is highly water-insoluble and must be conjugated with glucuronides to become water soluble and subsequently excreted by the liver and kidney.

Chemical Properties

Light Orange to Deep Redish-Brown Crystalline Solid

Uses

Principal pigment of bile and constituent of many biliary calculi

Uses

Bilirubin is widely utilized to monitor the liver function and their disease, such as hepatitis or cirrhosis; or the effects of medicines which are damage the liver. It acts as a pigment in certain algae to capture light energy. Its double bonds are isomerizes in the presence of light, which is employed in phototherapy of jaundiced newborns babies. It is used to detect the blocking in bile ducts.

Uses

Bilirubin has been used:

in phantom preparation
in in vitro experiments
in the preparation of bilirubin solutions for infusion

Definition

Red coloring matter of bile. Also occurs in blood serum as decomposition product of hemoglobin.

General Description

Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.

Biochem/physiol Actions

Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher. This bile pigment has both antioxidant and toxic properties. It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs). It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases. Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease. It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.

Purification Methods

An acyclic tetrapyrrole bile pigment with impurities which can be eliminated by successive Soxhlet extraction with diethyl ether and MeOH. It crystallises from CHCl3 as deep red-brown rhombs, plates or orange-red prisms from chlorobenzene (m 330o dec) and is dried to constant weight at 80o under vacuum. [Gray et al. J Chem Soc 2264, 2276 1961, Beilstein 26 III/IV 3268.]

Bilirubin Preparation Products And Raw materials

Raw materials

Calcium chloride solution 36-40%, (1box=27kgs) BILIVERDIN DIHYDROCHLORIDE Hexanoyl chloride B12 VITAMIN B12 Glycine Chloroform Carbon disulfide Benzotrichloride L-Histidine D-Alanine Sodium metabisulfite

Preparation Products

Hyodeoxycholic acid Atificial Cow-bezoar

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Bilirubin Suppliers

Belgium 2 Brazil 1 Canada 2 China 451 Czech Republic 1 Europe 4 France 1 Germany 7 India 31 Japan 3 Slovakia 1 Switzerland 5 United Kingdom 15 United States 58 Venezuela 1 Global 583

GLR Innovations

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View Lastest Price from Bilirubin manufacturers

HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD

Product: Bilirubin 635-65-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50
Release date: 2024-11-08

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Bilirubin 635-65-4
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 10 KGS
Release date: 2021-06-10

Baoji Guokang Bio-Technology Co., Ltd.

Product: Bilirubin 635-65-4
Price: US $19.60/g
Min. Order: 100g
Purity: 98%
Supply Ability: 100kg
Release date: 2021-06-08

635-65-4, BilirubinRelated Search:

BILIRUBIN OXIDASE,BILIRUBIN: OXYGEN OXIDOREDUCTASE,BILIRUBIN OXIDASE, FROM MYROTHECIUM SP. Bilirubin DEEP RED BILIRUBIN DIMETHYL ESTER Bilirubin Di-acyl--D-glucuronide,Bilirubin IXα glucronide,Bilirubin IXαdiglucuronide,Bilirubin glucuronide Bilirubin Acyl--D-glucuronide(Mixture of Monoglucuronides) Bilirbin paper BILIRUBIN REFERENCE Fouchet's Reagent for Bilirubin in Urine TOTAL BILIRUBIN REAGENT, CUSTOM PACK DIRECT BILIRUBIN DILUENT TOTAL BILIRUBIN REAGENT BILIRUBIN KIT TOTAL BILIRUBIN DILUENT ANTI-BILIRUBIN OXIDASE, PEROXIDASE,ANTI-BILIRUBIN OXIDASE, MYROTHECIUM VERRUCARIA, HRP BILIRUBIN, TOTAL DIAGNOSTIC REAGENT BILIRUBIN STANDARD SET ANTI-BILIRUBIN OXIDASE, MYROTHECIUM VERRUCARIA, BIOTIN,ANTI-BILIRUBIN OXIDASE, BIOTIN Indirect Bilirubin

1，10，19，22，23，24-hexahydro-2，7，13，17-tetramethyl-1，19-dioxo-3，18-divinylbilidiene-8，12-dipropionic acid

(Z,Z)-Bilirubin

Biline-8,12-dipropionic acid, 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-

Cholerythrin

Bilirubin,99%

Bilirubin, synthesis grade

Bilibubin

Biliyubin

Bilirubin, 99% 1GR

Bilirubin, 99% 500MG

12-dipropanoicacid,2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8

18-divinyl-19-dioxo-3

21h-biline-8,12-dipropanoicacid,2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7

bilirubinix-alpha

1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-

1,19-dioxo-

21H-Biline-8,12-dipropanoicacid,2,17-diethenyl-

BILIRUBIN extrapure AR

3-[2-[[3-(2-carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-2-pyrrolylidene)methyl]-4-methyl-3H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-2-pyrrolylidene)methyl]-4-methyl-3H-pyrrol-3-yl]propanoic ac

,13,18-tetramethyl-1,19-dioxo-

1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-biline-12-dipropionicacid

Bilirubin - CAS 635-65-4 - Calbiochem

hemetoidin

principalbilepigment

BILIRUBIN CALIBRATOR, TOTAL & DIRECT

BILIRUBIN CONTROL, TOTAL AND DIRECT*ELEVATED

BILIRUBIN LIN-TROL TOTAL & DIRECT

BILIRUBIN MIXED ISOMERS

BILIRUBIN STANDARD

BILIRUBIN CONTROL, TOTAL AND DIRECT*NORMAL

BILIRUBIN LIN-TROL PREDILUTED SET

BILIRUBIN: 21H-BILINE-8,12-DIPROPANOICACID,2,17-DIETHENYL-1,10,19,22,23,24-HEXAHYDRO-3,7,13,18-TETRAMETHYL-1,19-DIOXO-,

D-BiotinForBiochemistry(VitaminH)

BilirubinGr

Bilirubin,97%

2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetrametyl-1,19-dioxo-21H-biline-8,12-dipropanoic Acid

Bilirubin IXa

21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-

3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid

filirubin

12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8

BILIRUBIN REAGENT-GRADE

Bilirubin from Porcine

3-{2-({3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylid

Obeticholic Acid2

HEMATOIDIN

BILIRUBIN (EX PIG)

BILIRUBIN

BILIRUBIN (ALPHA)

21H-BILINE-8,12-DIPROPANOIC ACID,2,17-DIETHENYL-1,10,19,22,23,24-HEXAHYDRO-3,7,13,18-TETRAMETHYL-1,19-DIOXO-

2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid

Indirect bilirubin

Bilirubin USP/EP/BP

3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((Z)-(3-methyl-5-oxo-4-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((Z)-(4-methyl-5-oxo-3-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid

Bilirubin, GR 99%+

bilirubin?powder

3- (2- (3- (2-carboxyethyl) -4-methyl-5- ((Z) - (3-methyl-5-oxy-4-vinyl-1H-pyrrole-2 (5H) - subunit) methyl) -1H-pyrrole-2-yl) methyl) -4-methyl-5- (Z) - (4-methyl-5-oxy-3-vinyl-1H-pyrrole-2 (5H) - subunit) methyl) -1H-pyrrole-3-yl) propionic acid

Bilirubin Impurity