Natural progesterone Side effects of human estrogen
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Drospirenone

Natural progesterone Side effects of human estrogen
Product Name
Drospirenone
CAS No.
67392-87-4
Chemical Name
Drospirenone
Synonyms
Drospirenon;Drospirenona;DROSPIRENONE INTERMEDIATE;17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone;6b,7b;ZK 3059;ZK 30595;Spironone;Drospirone;arbolactone
CBNumber
CB8695608
Molecular Formula
C24H30O3
Formula Weight
366.5
MOL File
67392-87-4.mol
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Drospirenone Property

Melting point:
196-200°C
alpha 
-180 º (c=0.5, chloroform)
Boiling point:
552.2±50.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥15
form 
powder
color 
white to tan
optical activity
[α]/D -180 to -195°, c = 1 in methanol
InChI
InChI=1/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/s3
InChIKey
METQSPRSQINEEU-URUUTGNFNA-N
SMILES
C[C@]12CC[C@]3([H])[C@]4(CCC(=O)C=C4[C@@H]4C[C@@H]4[C@@]3([H])[C@]1([H])[C@@H]1C[C@@H]1[C@]12CCC(=O)O1)C |&1:1,4,6,13,15,16,18,20,22,23,r|
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Safety

Hazard Codes 
T
Risk Statements 
60
Safety Statements 
36/37
WGK Germany 
3
RTECS 
WH1299000
HS Code 
2937230000
Hazardous Substances Data
67392-87-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0147
Product name
Drospirenone
Purity
≥98% (HPLC)
Packaging
10mg
Price
$97.9
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR3314
Product name
Drospirenone
Purity
certified reference material, pharmaceutical secondary standard
Packaging
500MG
Price
$208
Updated
2024/03/01
Sigma-Aldrich
Product number
1229409
Product name
Drospirenone
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
23347
Product name
Drospirenone
Purity
≥98%
Packaging
10mg
Price
$54
Updated
2024/03/01
Cayman Chemical
Product number
23347
Product name
Drospirenone
Purity
≥98%
Packaging
50mg
Price
$231
Updated
2024/03/01
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Drospirenone Chemical Properties,Usage,Production

Natural progesterone

Drospirenone is the only progesterone that has the characteristics similar to the natural progesterone currently, its structure is more like that of the natural progesterone compare with the structure of the progesterone contained in the traditional oral contraceptives.
Except the effect of anti-androgen, drospirenone has the role of anti-mineralocorticoid which can prevent water and sodium retain in the body. Not only it has the a great effectivenes of contraception, there are also many good impacts on women's health like reducing the acne, making the skin more smooth and controling the weight efficaciously.
Information on the use of oral contraceptives, drospirenone, side effects and other information edited by Chemicalbook maggie.

Side effects of human estrogen

Drospirenone is a new synthetic progestin designed to mimic the effects of progesterone, it is the preogesterone which the pharmacological properties is closet to that of the natural progesterone, its also has the advantages of both salt corticosteroids and anti-androgen.
As a birth control hormones， Its can reduce the risk of pregnency by imitating progesterone, and increasing the levels of hormones. Therefore drospirenone is promoted as an effective contraception. However, since it has entered the market, drospirenone displays a negative impact on the female estrogen. When two hormones are mixed together, it would bring some bad influence to people.
When drospirenone reacts with estrogen, it can cause the blood thicken. It looks not like a big problem, but the blood clotting would lead to the formation of the thrombosis. The gore forming in the veins can impede blood flow or even plug in some vital organs like the heart, brain and lungs etc when it flowing. The thrombosis would Interference the heart from receiving blood which can cause a heart attack. If it affect the blood flow in brain, it would resulting in a stroke.
There is a possibility of side effects for any women who take the drospirenone, but the people who is obesity, smoking, depression, and have some diseases like the diabetes and high blood pressure are more likely to form the thrombosis when they take the contraception contained the drospirenone.

Description

Drospirenone is a synthetic progestogen that binds to the progesterone, mineralocorticoid, and androgen receptors with binding affinities of 20, 230, and 65% relative to R5020, aldosterone , and R1881, respectively. In vivo, drospirenone inhibits spontaneous ovulation in rats (ID50s = 0.3-1.0 mg/day) when administered orally or subcutaneously. Drospirenone (0.5 mg/animal) administered six times per day maintains pregnancy in ovariectomized pregnant rats. It reduces serum testosterone (Item Nos. 15645 | ISO60154) and luteinizing hormone in cynomolgus monkeys in a dose-dependent manner. Drospirenone (10 mg/animal per day) also inhibits testosterone-induced growth of the seminal vesicles and prostate in castrated rats. Formulations containing drospirenone have been used as oral contraceptives.

Description

The steroid drospirenone in combination with the estrogen agonist ethinylestradiol was introduced in Germany as a new oral contraceptive for women. This analog of the aldosterone antagonist spironoiactone can be synthesized in five steps from 3β-hydroxy- 15β,16β-methylene-5-androsten-l7-one. Since its binding profile for steroid receptors is very similar to progesterone, drospirenone mimics the progestogen agonistic activity as well as the anti-androgenic and anti-mineralocorticoid properties of the endogenous hormone. In rats, drospirenone inhibited ovulation at 6.3 mglkglday p.o. Compared with currently available progestins which lack anti-mineralocorticoid activity, drospirenone did not cause weight gain that could result from fluid retention in clinical studies. Its combination with ethinylestradiol was well tolerated and did not engender adverse effects on blood pressure or plasma lipid levels. Drospirenone is rapidly absorbed in man with an oral bioavailability of 76%. It is extensively metabolized since over 20 different metabolites were observed in the urine and in the feces, resulting for instance from hydrolysis of the lactone in the plasma or reductive conjugation of the enone to the 3-sulfate ester of 45 dihydrodrospirenone. Its elimination is bi-exponential with an initial and a terminal half-life of 2 and 25-33h respectively.

Chemical Properties

Off-White Crystalline Powder

Originator

Schering AG (Germany)

Uses

Synthetic progestogen exhibiting antimineralocorticoid and antiandrogenic activity.

Uses

antiviral

Uses

anti-cancer therapeutic

Uses

Drospirenone has been used as a progestogen agent in pond snail and fish.

Definition

ChEBI: Drospirenone is a steroid lactone and a 3-oxo-Delta(4) steroid. It has a role as a contraceptive drug, an aldosterone antagonist and a progestin.

Manufacturing Process

2.75 g of trimethyl sulfoxonium iodide is stirred in 57 ml of dimethyl sulfoxide with 341 mg of 80% sodium hydride oil suspension for 2 h at room temperature. The almost clear solution is combined under nitrogen with 2.0 g of 15α,16α-methylene-3-oxo-4,6-androstadiene-[17(β-1')-spiro- 5']perhydrofuran-2'-one and agitated for 24 h at room temperature. The mixture is then stirred into ice water, the thus-obtained precipitate is filtered off, washed with water, and taken up in methylene chloride. After drying and evaporation, the residue is purified by repeated preparative layer chromatography, thus obtaining 520 mg of 6β,7β,15α,16α-dimethylene-3-oxo- 4-androstene-[17(β-1')-spiro-5']perhydrofuran-2'-one (drospirenone).

brand name

Yasmin

Therapeutic Function

Aldosterone antagonist

General Description

Drospirenone, 3-oxo-6β,7β:15β,16β-dimethylene-17α-pregn-4-en-21,17-carbolactone,differs structurally from all the other commercially availableprogestins. Its structure is similar to that of spironolactone,an MR antagonist, and it does have antimineralocorticoidactivity as well as progestational activity. It isalso reported to have some antiandrogenic effects. Thespirolactone at C17 and the two cyclopropyl groups at C6-C7 and C15-C16 contribute to these unique actions.Drospirenone is the progestin component in the newer oralcontraceptives, Yasmin and Yaz, and in the HRT product,Angeliq.

Biochem/physiol Actions

Drospirenone is a fourth-generation progestin that has antimineralocorticoid, and antiandrogenic activity in addition to potent progestogenic activity. In two recent studies drospirenone appeared to double the risk of venous thromboembolism compared to levonorgestrel, although other studies found little added risk.

Drospirenone Preparation Products And Raw materials

Raw materials

Preparation Products

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Drospirenone Suppliers

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View Lastest Price from Drospirenone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Drospirenone 67392-87-4
Price
US $0.00/g
Min. Order
10g
Purity
98.0-102.0%,USP40
Supply Ability
50kg/month
Release date
2021-06-19
airuikechemical co., ltd.
Product
Drospirenone 67392-87-4
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
20 tons
Release date
2024-04-07
Wuhan Haorong Biotechnology Co.,Ltd
Product
Drospirenone 67392-87-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000
Release date
2023-07-27

67392-87-4, DrospirenoneRelated Search:

Buspirone hydrochloride Tandospirone Buspirone topterone Dihydrojasmone lactone 17-Methyltestosterone BRASSIDIC ACID Testosterone propionate (S)-1-CYCLOPROPYLETHANOL Chrysene Drospirenone Acid Potassium Salt Calusterone ETHYLIDENECYCLOHEPTANE ISO-PROPENYLCYCLOPROPANE (S)-4-NONANOLIDE STANDARD FOR GC 1-CYCLOPROPYL-1-METHYLETHANOL DROSPIRENONE-D4 (S)-4-DODECANOLIDE STANDARD FOR GC

  • 17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone
  • 7β-(HydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21,17-carbolactone
  • Drospirenone(Dihydrospirorenone)
  • Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione
  • Drospirenone (USP32)
  • Drospirenone, >=98%
  • Drosporenone
  • 6b,7b:15b,16b-Dimethylen-3-oxo-17a-pregn-4-ene-21
  • 6β,7β:15β,16β -Dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone
  • Drospirenone for peak identification
  • 17-beta))-16-alpha
  • 6-beta,7-beta
  • arbolactone
  • ,5’(2h)-dione,1,3’,4’,6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-
  • 1,2-dihydrospirorenone
  • 15-beta,16-beta-dimethylene-3-oxo-17-alpha-pregn-4-ene-21,17-c
  • ZK 3059
  • DROSPIRENONE INTERMEDIATE
  • DEHYDROSPIRORENONE
  • 6b,7b:15b,16b-Dimethylen-3-oxo-17a-pregn-4-ene-21,17-carbolactone
  • 6,7,15,16-Dimethylene-3-oxo-4-androstene-[17(-1’)-spiro-5’]perhydrofuran-2’-one
  • ZK 30595
  • dimethyl-,(6r-(6-alpha,7-alpha,8-beta,9-alpha,10-beta,13-beta,14-alpha,15-alph
  • spiro(17h-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2’(5’h)-furan)-3
  • Drospirenone, USP
  • 3-Oxo-6β,7β:15β,16β-diMethylene-17α-pregn-4-en-21,17-carbolactone
  • 6b,7b
  • 6b,7b,15b,16b-Dimethylene-3-oxo-4-androstene-[17(b-1-spiro-5perhydrofuran- 2one
  • (6R,17S)-1,3',4',6α,7α,8β,9α,10,11,12,13,14α,15α,16α,20,21-Hexadecahydro-10β,13β-dimethylspiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione
  • Dorospirenone
  • Drospirenone (200 mg)
  • dihydrospirorenone
  • DROSPIRENONE
  • Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethyl-, [6R-(6alpha,7alpha,8beta,9alpha,10beta,13beta,14alpha,15alpha,16alpha,17b
  • 15b,16b-dimethylen-3-oxo-17a-pregn-4-ene-21,17-carbolactone
  • Drospirenon
  • Drospirenona
  • Drospirenone-20,20,21,21-d4
  • Drospirenone CRS
  • Drospirenone&gt
  • Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethyl-, (2'S,6R,7R,8R,9S,10R,13S,14S,15S,16S)-
  • (2'S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR)-4a,6a-dimethyl-4,4a,4b,5,6,6a,7a,8,8a,8b,8c,8d,9,9a-tetradecahydro-3'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-7,2'-furan]-2,5'(3H,4'H)-dione
  • Drospirenone USP/EP/BP
  • (4aR,4bS,6aS,7S,7aS,8aS,8bS,8cR,8dR,9aR)-4a,6a-dimethyl-3',4,4a,4b,4',5,6,6a,7a,8,8a,8b,8c,8d,9,9a-hexadecahydro-5'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-7,2'-furan]-2,5'(3H)-dione
  • Drospirenone D4Q: What is Drospirenone D4 Q: What is the CAS Number of Drospirenone D4 Q: What is the storage condition of Drospirenone D4 Q: What are the applications of Drospirenone D4
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  • 1-[1-[4-[4-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-3,6-dihydropyridin-1(2H)-yl]-1-oxobutyl]phenyl]-1,2,3,6-tetrahydropyridin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one.
  • Drospirone
  • Drospirenone-d4 (3',3',4',4'-d4)
  • 5a,7a-dimethyl-1,1a,5,5a,5b,6,7,7a,8a,9,9a,9b,9c,9d-tetradecahydro-3'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-8,2'-furan]-3,5'(4H,4'H)-dione
  • drospirodone
  • 67392-87-4
  • 7392-87-4