1-Naphthyl isothiocyanate

ChemicalBook > CAS DataBase List > 1-Naphthyl isothiocyanate

1-Naphthyl isothiocyanate

Product Name: 1-Naphthyl isothiocyanate
CAS No.: 551-06-4
Chemical Name: 1-Naphthyl isothiocyanate
Synonyms: ANI;ANIT;Kesscocide;1-Naphthyl senfoel;Naphthyl mustard oil;1-Naftylisothiokyanat;Naphthyl isothiocyanat;1-NAPTHYL ISOTHIOCYANATE;1-Naphtyl isothiocyanate;1-NAPHTHYL ISOTHIOCYANATE
CBNumber: CB8696418
Molecular Formula: C11H7NS
Formula Weight: 185.24
MOL File: 551-06-4.mol

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1-Naphthyl isothiocyanate Property

Melting point:: 55.5-57 °C(lit.)
Boiling point:: 190 °C(Press: 20 Torr)
Density: 1.1142 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: 2-8°C
form: Fine Crystalline Powder
color: Yellow
Water Solubility: insoluble
Sensitive: Moisture Sensitive
Merck: 14,6411
BRN: 637868
Stability:: Stable, but moisture sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 551-06-4(CAS DataBase Reference)
NIST Chemistry Reference: Naphthalene, 1-isothiocyanato-(551-06-4)
EPA Substance Registry System: 1-Naphthylisothiocyanate (551-06-4)

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Safety

Hazard Codes: T
Risk Statements: 20/21-25-36/37/38-42-23/24/25
Safety Statements: 22-26-36/37-45-24/25
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: NX9100000
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N4525
Product name: 1-Naphthyl isothiocyanate
Purity: 95%
Packaging: 10g
Price: $173
Updated: 2024/03/01

Sigma-Aldrich

Product number: 18951
Product name: 1-Naphthyl isothiocyanate
Purity: for HPLC derivatization, ≥98.5% (HPLC and GC)
Packaging: 1g
Price: $51.2
Updated: 2022/05/15

TCI Chemical

Product number: I0190
Product name: 1-Naphthyl Isothiocyanate
Purity: >98.0%(GC)
Packaging: 5g
Price: $85
Updated: 2024/03/01

TCI Chemical

Product number: I0190
Product name: 1-Naphthyl Isothiocyanate
Purity: >98.0%(GC)
Packaging: 25g
Price: $265
Updated: 2024/03/01

Alfa Aesar

Product number: L12418
Product name: 1-Naphthyl isothiocyanate, 98%
Packaging: 10g
Price: $109.65
Updated: 2024/03/01

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1-Naphthyl isothiocyanate Chemical Properties,Usage,Production

Description

1-Napthylisothiocyanate is a toxic chemical that has been used to create experimental cholestasis in rodents. Laboratory studies have also shown that 1-napthylisothiocyanate can act as a chemoprotectant in rodents challenged with a tumorinducing agent such as phorbol-12 myristate 13-acetate.

Chemical Properties

white crystalline powder

Uses

1-Naphthylisothiocyanate is used as an ingredient in insecticides. It is also found in cyanamide, which is used in many industrial applications. It is commonly used in medical and drug studies in animals as a model hepatotoxicant producing experimental cholestasis in rats and mice.

Uses

1-Naphthyl isothiocyanate is a tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function.

Uses

1-Naphthyl isothiocyanate (NITC) can be used as a source of thiourea moiety to synthesize derivatives of calix[4]arenes to be used as anion acceptors. It can also be used for the synthesis of naphthyl substituted 1,2,4-triazoles and 1,3,4-thiadiazoles.

Definition

ChEBI: 1-naphthyl isothiocyanate is an isothiocyanate. It has a role as an insecticide. It derives from a hydride of a naphthalene.

General Description

Odorless white needles or powder. Tasteless.

Air & Water Reactions

1-Naphthyl isothiocyanate is moisture sensitive. . Undergoes slow hydrolysis. Insoluble in water.

Reactivity Profile

Isocyanates and thioisocyanates, such as 1-Naphthyl isothiocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

Fire Hazard

Flash point data for 1-Naphthyl isothiocyanate is not available, but 1-Naphthyl isothiocyanate is probably combustible.

Environmental Fate

Naphthylisothiocyanate is moisture sensitive and insoluble in water. The hydrolysis rate is slow.

Purification Methods

Crystallise the isothiocyanate from hexane (1g in 9 mL). It forms white needles and is soluble in most organic solvents but is insoluble in H2O. It is absorbed through the skin and may cause dermatitis. [Cymmerman-Craig et al. Org Synth Coll Vol IV 700 1963, Beilstein 12 H 1244, 12 III 2948.]

Toxicity evaluation

1-Naphthylisothiocyanate causes separation of extracellular tight junctions that seal bile canaliculi, impairing bile formation. 1-Naphthylisothiocyanate inhibits microsomal drug-metabolizing activity. In rats, 1-naphthylisothiocyanteglutathione complex is formed in hepatocytes, then transported to the bile ducts, where it is released from the glutathione, and then selectively injures biliary epithelial cells, resulting in reduced bile flow.

1-Naphthyl isothiocyanate Preparation Products And Raw materials

Raw materials

1-(1-NAPHTHYL)-2-THIOUREA

Preparation Products

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1-Naphthyl isothiocyanate Suppliers

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View Lastest Price from 1-Naphthyl isothiocyanate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Naphthyl isothiocyanate 551-06-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1-Naphthyl isothiocyanate 551-06-4
Price: US $1.00/KG
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20ton
Release date: 2019-12-20

551-06-4, 1-Naphthyl isothiocyanateRelated Search:

Phenyl isothiocyanate Fluorescein isothiocyanate Phenyl isocyanate Liranaftate Chlorosulfonyl isocyanate 1-(1-NAPHTHYL)-2-THIOUREA Isocyanatocyclohexane ISOCYANIC ACID 1,4-PHENYLENE DIISOTHIOCYANATE Allyl isothiocyanate 4-DIMETHYLAMINO-1-NAPHTHYL ISOTHIOCYANATE isothiocyanic acid ISOTHIOCYANATE, POLYMER-BOUND, 200-400 5-HYDROXYNAPHTHYLISOTHIOCYANATE 8-ISOTHIOCYANATOPYRENE-1,3,6-TRISULFONIC ACID TRISODIUM SALT 1-Naphthyl isothiocyanate NAPHTHALENE, 1-CYCLOPROPYL-4-ISOTHIOCYANATO- 1-PYRENEISOTHIOCYANATE

1-Isothiocyanatenaphthalene

1-isothiocyanate-naphthalene

1-NAPHTHYL ISOTHIOCYANATE >95%

1-NAPHTHYL ISOTHIOCYANATE 98%

1-Naphthyl senfoel

1-Naphthyl isothiocyanate,98%

1-NAPTHYL ISOTHIOCYANATE

1-Naphthyl isothiocyanate, 98% 5GR

1-Naphthyl isothiocyanate, derivatization grade

Naphthyl isothiocyanat

1-Naphthyl isothiocyanate, 98%, derivatization grade

1-phthyl isothiocyate, 98%

1-NAPHTHYL ISOTHIOCYANATE

ALPHA-NAPHTHYL ISOTHIOCYANATE

α-Naphthyl isothiocyanate

Naphthyl mustard oil

ISOTHIOCYANIC ACID 1-NAPHTHYL ESTER

1-isothiocyanato-naphthalen

1-Isothiocyanatonaphthalene

1-iso-Thiocyanatonaphthalene

1-Naftylisothiokyanat

1-Naphthalene isothiocyanate

alpha-Naphthysothiocyanate

ANI

ANIT

isothiocyanato-naphthalen

Kesscocide

Naphthalene, isothiocyanato-

1-Naphtyl isothiocyanate

1-NaphthylIsothiocyanate&gt

Naphthalene, 1-isothiocyanato-

551-06-4

C10H7NCS

C11H7NS

Organic Building Blocks

Thiocyanates/Isothiocyanates

Sulfur Compounds

Building Blocks

ISOTHIOCYANATE

Thiocyanates/IsothiocyanatesDerivatization Reagents

Derivatization Reagents HPLC

Organic Building Blocks

Sulfur Compounds

UV-VIS