ChemicalBook > CAS DataBase List > PREGNENOLONE SULFATE SODIUM SALT

PREGNENOLONE SULFATE SODIUM SALT

Product Name: PREGNENOLONE SULFATE SODIUM SALT
CAS No.: 1852-38-6
Chemical Name: PREGNENOLONE SULFATE SODIUM SALT
Synonyms: Pregnenolone 3-Sulfate;PREGNENOLONE SULFATE SODIUM;Pregnenolone-3-sulfate Sodium;SodiuM Pregnenolone-d4 Sulfate;5-Pregnen-3β-ol-20-one sulfate;Pregnenolone sulphate Na+ salt;Pregnenolone monosulfate sodium;PREGNENOLONE SULFATE SODIUM SALT;PREGNENOLONE SULPHATE, SODIUM SALT;Pregnenolone-3-sulfate SodiuM Salt
CBNumber: CB8701970
Molecular Formula: C21H31NaO5S
Formula Weight: 418.52
MOL File: 1852-38-6.mol

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PREGNENOLONE SULFATE SODIUM SALT Property

Melting point:: 192 °C(lit.)
storage temp.: Store at -20°C
solubility: methanol and water: 1.93 mg/mL
form: A crystalline solid
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P162
Product name: Pregnenolone sulfate sodium salt
Packaging: 25mg
Price: $28.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: P162
Product name: Pregnenolone sulfate sodium salt
Packaging: 100mg
Price: $82.74
Updated: 2025/07/31

Cayman Chemical

Product number: 21004
Product name: Pregnenolone sulfate (sodium salt)
Purity: ≥95%
Packaging: 50mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 21004
Product name: Pregnenolone sulfate (sodium salt)
Purity: ≥95%
Packaging: 100mg
Price: $80
Updated: 2024/03/01

Cayman Chemical

Product number: 21004
Product name: Pregnenolone sulfate (sodium salt)
Purity: ≥95%
Packaging: 250mg
Price: $163
Updated: 2024/03/01

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PREGNENOLONE SULFATE SODIUM SALT Chemical Properties,Usage,Production

Description

Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).

Uses

Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3).

Uses

Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor.

Biochem/physiol Actions

Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA?) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.

in vivo

Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule^[1].

IC 50

CB1; Human Endogenous Metabolite

storage

Store at +4°C

References

[1] M SEDLáCEK. Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission.[J]. Physiological research, 2008, 57 Suppl 3: S49-S57. DOI: 10.33549/physiolres.931600
[2] CONOR C SMITH David H F Terrell T Gibbs. Pregnenolone sulfate as a modulator of synaptic plasticity.[J]. Psychopharmacology, 2014, 231 17: 3537-3556. DOI: 10.1007/s00213-014-3643-x
[3] GERALD THIEL Oliver G R Isabelle Müller. Signal transduction via TRPM3 channels in pancreatic β-cells.[J]. Journal of molecular endocrinology, 2013, 50 3: R75-83. DOI: 10.1530/jme-12-0237

PREGNENOLONE SULFATE SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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PREGNENOLONE SULFATE SODIUM SALT Suppliers

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1852-38-6, PREGNENOLONE SULFATE SODIUM SALTRelated Search:

Pregnenolone-[20,21-13C2, 16,16-d2] sulfate sodium salt (Solution) DIAMOND Pregnanolone-[d5] Pregnenolone-[20,21-13C2, 16,16-D2] sulfate sodium salt Sodium Pregnenolone-17α,21,21,21-d4 Sulfate PREGNENOLONE-17ALPHA,21,21,21-D4 Pregnenolone-2,2,4,4-d4 Pregnenolone-[20,21-13C2, 16,16-D2] 5-Pregnen-3β-ol-20-one-17α?21?21?21-d4 3-Methyl Ether Pregnenolone-[20,21-13C2, 16,16-d2] Pregnenolone 5-PREGNEN-3-BETA, 17-DIOL-20-ONE 3-SULPHATE SODIUM SALT PREGNENOLONE SULFATE SODIUM SALT PREGNENOLONE [7-3H(N)]-3-SULFATE, SODIUM SALT 21-HYDROXYPREGNENOLONE 3 SULPHATE SODIUM PREGNENOLONE-17ALPHA,21,21,21-D4 SULFATE

PREGNENOLONE SULFATE SODIUM

PREGNENOLONE SULFATE SODIUM SALT

Pregnenolone monosulfate sodium salt

(3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt

PREGNENOLONE SULPHATE, SODIUM SALT

3B-HYDROXY-5-PREGNEN-20-ONE 3-SULFATE SODIUM SALT

3-BETA-HYDROXY-5-PREGNEN-20-ONE 3-SULPHATE, SODIUM SALT

3-HYDROXYPREGN-5-EN-20-ONE SULFATE SODIUM SALT

5-PREGNEN-3BETA-OL-20-ONE SULFATE SODIUM SALT

5-PREGNEN-3-BETA-OL-20-ONE SULPHATE, SODIUM SALT

5-PREGNEN-3B-OL-20-ONE SULFATE SODIUM SALT

5-PREGNEN-3BETA-OL-20-ONE3-SULFATE SODIUM

5-pregnen-3B-ol-20-one sulfate sodium

PREGNENOLONE SULFATE SODIUM SALT 5-PREGN EN-3B-OL-20-ON

5-Pregnen-3-beta-ol-2o-one sulphate,sodium salt

3β-Hydroxy-5-pregnen-20-one 3-sulfate, 3-Hydroxypregn-5-en-20-one sulfate, 5-Pregnen-3β-ol-20-one sulfate

SodiuM Pregnenolone-d4 Sulfate

Pregnenolone-3-sulfate SodiuM Salt

3-Hydroxypregn-5-en-20-one sulfate

3β-Hydroxy-5-pregnen-20-one 3-sulfate

5-Pregnen-3β-ol-20-one sulfate

Pregnenolone sulphate Na+ salt

3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt

Pregnenolone 3-Sulfate

Pregnenolone-3-sulfate Sodium

5-PREGNEN-3β-OL-20-ONE SULPHATE, SODIUM SALT

3β-Hydroxy-5-Pregnen-20-One 3-Sulphate

Pregnenolone monosulfate sodium

1852-38-6

C21H31NaO5S

C21H31O5SNa

Cell Signaling and Neuroscience

Cell Biology

BioChemical

GABA and Glycine Receptor Modulators

Ion Channels

Ligand-Gated Ion Channels

Steroids