AC-SER-ASP-LYS-PRO-OH
Skin Benifits- Product Name
- AC-SER-ASP-LYS-PRO-OH
- CAS No.
- 127103-11-1
- Chemical Name
- AC-SER-ASP-LYS-PRO-OH
- Synonyms
- AC-SDKP;GORALATIDE;Acetyl-SDKP;SERASPENIDE;AC-SDKP-DELTA;Thymosin β4 (1-4);Thymosin β4 (1-4);AC-SER-ASP-LYS-PRO;Thymosin beta4 (1-4);AC-SER-ASP-LYS-PRO-O
- CBNumber
- CB8704926
- Molecular Formula
- C20H33N5O9
- Formula Weight
- 487.5
- MOL File
- 127103-11-1.mol
AC-SER-ASP-LYS-PRO-OH Property
- Boiling point:
- 992.0±65.0 °C(predicted)
- Density
- 1.382±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
- storage temp.
- −20°C
- solubility
- Soluble in DMSO
- pka
- 3.39±0.20(predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Soluble in water at 2mg/ml
- Sequence
- H-Gln-Lys-Leu-Val-Phe-Phe-Ala-OH
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- J66430
- Product name
- N-Acetyl-Ser-Asp-Lys-Pro
- Packaging
- 5mg
- Price
- $64.6
- Updated
- 2023/06/20
- Product number
- FA108367
- Product name
- Ac-Ser-Asp-Lys-Pro-OH
- Packaging
- 5mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- FA108367
- Product name
- Ac-Ser-Asp-Lys-Pro-OH
- Packaging
- 10mg
- Price
- $228
- Updated
- 2021/12/16
- Product number
- FA108367
- Product name
- Ac-Ser-Asp-Lys-Pro-OH
- Packaging
- 25mg
- Price
- $456
- Updated
- 2021/12/16
- Product number
- PEP0002574
- Product name
- N-ACETYL-SER-ASP-LYS-PRO
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $718.47
- Updated
- 2021/12/16
AC-SER-ASP-LYS-PRO-OH Chemical Properties,Usage,Production
Skin Benifits
AcSDKP is an oligopeptide composed of acetyl-Ser-Asp-Lys-Pro. Found at low concentrations endogenously,
AcSDKP is produced from thymosin and inhibits the phosphorylation of Smad2, therefore
downsizing the expression of genes regulated by TGFβ. This mechanism mediates an antifibrotic effect
and a reduction in edema. AcSDKP is catabolized almost exclusively by angiotensin converting enzyme
I (ACEI), although ACEI-resistant analogs have been created. AcSDKP has been recognized as a potent
inducer of angiogenesis and an anti-inflammatory agent, also contributing to its anti-fibrotic effects. Its
cutaneous anti-aging effects have also been investigated. AcSDKP at a concentration of 10−7–10−11
stimulates the expression of proteins that strengthen tight junctions, including caludin-1, occluding,
and ZO-1.
In an ex vivo study, topical AcSDKP accelerated skin healing after UV irradiation. AcSDKP
also stimulates the proliferation of keratinocytes, fibroblasts, and epidermal basal layer cells. Topical
application of 10−5 M AcSDKP also inhibits aging of human skin explants by significantly increasing
epidermal thickness after only six days, increases collagen III along the papillary dermis and collagen
IV along the basal membrane, with a concomitant increase in GAGs, especially HA. This peptide also
modulates the growth of human hair in an ex vivo study. Treatment of normal human dermal fibroblast
cells with AcSDKP showed increased collagen I synthesis and SIRTI, improving skin structure and
increasing cell longevity.78 In one study, topically administered AcSDKP on an ex vivo skin-explant
model significantly increases epidermis thickness after only six days of treatment with 10−8 M AcSKDP.
In addition to upregulating the expression of collagen and fibronectin along the dermo-epithelial junction,
AcSKDP also increases GAG deposited in the ECM, especially hyaluronic acid. Lastly, AcSDKP
encourages dermal fibroblasts and keratinocytes to proliferate and modulates hair growth.
Uses
N-Acetyl-Ser-Asp-Lys-Pro inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. It is a specific substrate for the N-terminal active site of angiotensin converting enzyme, which is responsible for its degradation in vivo.
AC-SER-ASP-LYS-PRO-OH Preparation Products And Raw materials
Raw materials
Preparation Products
AC-SER-ASP-LYS-PRO-OH Suppliers
- Tel
- 18750546777
- 18750546777@163.COM
- Country
- China
- ProdList
- 6070
- Advantage
- 58
- Tel
- 0571-88211921 15572296305
- sales4@gotopbio.com
- Country
- China
- ProdList
- 5178
- Advantage
- 58
- Tel
- 19135651983 19135651983
- 18611134419@163.com
- Country
- China
- ProdList
- 4416
- Advantage
- 58
- Tel
- +86-028-64348587 15680781153
- sales@takelepeptide.com
- Country
- China
- ProdList
- 86
- Advantage
- 58
- Tel
- 21-61263452 13641803416
- Fax
- 86-21-61263399
- ymbetter@glbiochem.com
- Country
- China
- ProdList
- 9981
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 0571-89197072; 18668118770
- Fax
- 0571-89197072
- linda@peptide-china.com
- Country
- China
- ProdList
- 248
- Advantage
- 56
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 7268
- Advantage
- 58
- Tel
- 17705183659
- Fax
- 84523390
- sales@njleonbiotech.com
- Country
- China
- ProdList
- 5501
- Advantage
- 55
- Tel
- 025-025-58361106-805-805 13082558573
- Fax
- 025-58361106-806
- liugang@njpeptide.com
- Country
- China
- ProdList
- 9980
- Advantage
- 55
- Tel
- +86-17380623303 +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4839
- Advantage
- 58
- Tel
- 027-83778895 18602735115
- Fax
- 027-51119224
- 18602735115@163.com
- Country
- China
- ProdList
- 1994
- Advantage
- 64
- Tel
- 0571-87213919
- Fax
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 6756
- Advantage
- 58
- Tel
- +86-0833-2598983 +86-18086877136
- Fax
- +86-833-2598903
- Nyx-peptide@jsjpharm.cn
- Country
- China
- ProdList
- 309
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +862156762820 +86-13564624040
- sales@myuchem.com
- Country
- China
- ProdList
- 7514
- Advantage
- 58
- Tel
- +8617621705551
- asdf@shanghaihg.cn
- Country
- China
- ProdList
- 264
- Advantage
- 58
- Tel
- +8617531190177
- peter@yan-xi.com
- Country
- China
- ProdList
- 5857
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +8615255079626
- eric@witopchemical.com
- Country
- China
- ProdList
- 23541
- Advantage
- 58
- Tel
- 0571-88211921
- sales1@gotopbio.com
- Country
- CHINA
- ProdList
- 2609
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 22883
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30240
- Advantage
- 58
- Tel
- 18871490254
- Fax
- 027-59599243
- linda@hubeijusheng.com
- Country
- CHINA
- ProdList
- 28172
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 028-81700200 18108052721
- 2850505130@qq.com
- Country
- China
- ProdList
- 5176
- Advantage
- 58
- Tel
- 021-13773155751 19975051755
- 260924549@qq.com
- Country
- China
- ProdList
- 8904
- Advantage
- 58
- Tel
- 0571-86758863 13867485072
- Fax
- 0571-86758863
- lulu@thinheal.com
- Country
- China
- ProdList
- 302
- Advantage
- 58
- Tel
- 19850819832
- 2173594524@qq.com
- Country
- China
- ProdList
- 2638
- Advantage
- 58
- Tel
- 029-84161958 18629577295
- Fax
- 029-84161958
- magic@lynabio.com
- Country
- China
- ProdList
- 1071
- Advantage
- 55
- Tel
- 021-61263455 13167021076
- amy@glschina.com
- Country
- China
- ProdList
- 8745
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58
- Tel
- 027-027-52344656 15871722230
- Fax
- 2796190295
- 15871722230@163.com
- Country
- China
- ProdList
- 4855
- Advantage
- 58
- Tel
- 0571-88760729 18072970094
- supports@ontorespeptide.com
- Country
- China
- ProdList
- 2696
- Advantage
- 58
- Tel
- 027-59506022 13419526507
- Fax
- 027-59506022
- 13419526507@163.com
- Country
- China
- ProdList
- 2995
- Advantage
- 58
- Tel
- 0571-88211921 13355716090
- Sales@gotopbio.com
- Country
- China
- ProdList
- 2861
- Advantage
- 58
- Tel
- 021-021-61109150
- Fax
- 021-61105897
- sales@tcisct.com
- Country
- China
- ProdList
- 31121
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 13774214275
- zhouzz@univ-bio.com
- Country
- China
- ProdList
- 24990
- Advantage
- 58
- Tel
- 18627756402
- 3001051413@qq.com
- Country
- China
- ProdList
- 9557
- Advantage
- 58
- Tel
- 13675144456
- alan.chow@synzest.com
- Country
- China
- ProdList
- 9470
- Advantage
- 58
- Tel
- 0551-67163798 19956525566
- he@synthbio.cn
- Country
- China
- ProdList
- 19
- Advantage
- 58
- Tel
- 17711399154
- 3211919385@qq.com
- Country
- China
- ProdList
- 1815
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 6445
- Advantage
- 58
- Tel
- 18671296875 18671296875
- 1205035102@qq.com
- Country
- China
- ProdList
- 4302
- Advantage
- 58
- Tel
- 15068777134
- 1289372011@qq.com
- Country
- China
- ProdList
- 207
- Advantage
- 58
View Lastest Price from AC-SER-ASP-LYS-PRO-OH manufacturers
- Product
- Goralatide 127103-11-1
- Price
- US $30.00/box
- Min. Order
- 1box
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-03-21
- Product
- Ac-Ser-Asp-Lys-Pro-OH 127103-11-1
- Price
- US $0.00-0.00/Gram
- Min. Order
- 1Gram
- Purity
- 98%
- Supply Ability
- 1KG
- Release date
- 2024-06-17
- Product
- Thymosin β4 (1-4) 127103-11-1
- Price
- US $30.00/Box
- Min. Order
- 1Box
- Purity
- 99.99%
- Supply Ability
- 10000000000
- Release date
- 2023-12-20