Skin Benifits
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AC-SER-ASP-LYS-PRO-OH

Skin Benifits
Product Name
AC-SER-ASP-LYS-PRO-OH
CAS No.
127103-11-1
Chemical Name
AC-SER-ASP-LYS-PRO-OH
Synonyms
AC-SDKP;GORALATIDE;Acetyl-SDKP;SERASPENIDE;AC-SDKP-DELTA;Thymosin β4 (1-4);Thymosin β4 (1-4);AC-SER-ASP-LYS-PRO;Thymosin beta4 (1-4);AC-SER-ASP-LYS-PRO-O
CBNumber
CB8704926
Molecular Formula
C20H33N5O9
Formula Weight
487.5
MOL File
127103-11-1.mol
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AC-SER-ASP-LYS-PRO-OH Property

storage temp. 
−20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
Water Solubility 
Soluble in water at 2mg/ml
Sequence
H-Gln-Lys-Leu-Val-Phe-Phe-Ala-OH
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J66430
Product name
N-Acetyl-Ser-Asp-Lys-Pro
Packaging
5mg
Price
$64.6
Updated
2023/06/20
Biosynth Carbosynth
Product number
FA108367
Product name
Ac-Ser-Asp-Lys-Pro-OH
Packaging
5mg
Price
$131
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA108367
Product name
Ac-Ser-Asp-Lys-Pro-OH
Packaging
10mg
Price
$228
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA108367
Product name
Ac-Ser-Asp-Lys-Pro-OH
Packaging
25mg
Price
$456
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0002574
Product name
N-ACETYL-SER-ASP-LYS-PRO
Purity
95.00%
Packaging
5MG
Price
$718.47
Updated
2021/12/16
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AC-SER-ASP-LYS-PRO-OH Chemical Properties,Usage,Production

Skin Benifits

AcSDKP is an oligopeptide composed of acetyl-Ser-Asp-Lys-Pro. Found at low concentrations endogenously, AcSDKP is produced from thymosin and inhibits the phosphorylation of Smad2, therefore downsizing the expression of genes regulated by TGFβ. This mechanism mediates an antifibrotic effect and a reduction in edema. AcSDKP is catabolized almost exclusively by angiotensin converting enzyme I (ACEI), although ACEI-resistant analogs have been created. AcSDKP has been recognized as a potent inducer of angiogenesis and an anti-inflammatory agent, also contributing to its anti-fibrotic effects. Its cutaneous anti-aging effects have also been investigated. AcSDKP at a concentration of 10−7–10−11 stimulates the expression of proteins that strengthen tight junctions, including caludin-1, occluding, and ZO-1.
In an ex vivo study, topical AcSDKP accelerated skin healing after UV irradiation. AcSDKP also stimulates the proliferation of keratinocytes, fibroblasts, and epidermal basal layer cells. Topical application of 10−5 M AcSDKP also inhibits aging of human skin explants by significantly increasing epidermal thickness after only six days, increases collagen III along the papillary dermis and collagen IV along the basal membrane, with a concomitant increase in GAGs, especially HA. This peptide also modulates the growth of human hair in an ex vivo study. Treatment of normal human dermal fibroblast cells with AcSDKP showed increased collagen I synthesis and SIRTI, improving skin structure and increasing cell longevity.78 In one study, topically administered AcSDKP on an ex vivo skin-explant model significantly increases epidermis thickness after only six days of treatment with 10−8 M AcSKDP. In addition to upregulating the expression of collagen and fibronectin along the dermo-epithelial junction, AcSKDP also increases GAG deposited in the ECM, especially hyaluronic acid. Lastly, AcSDKP encourages dermal fibroblasts and keratinocytes to proliferate and modulates hair growth.

Uses

N-Acetyl-Ser-Asp-Lys-Pro inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. It is a specific substrate for the N-terminal active site of angiotensin converting enzyme, which is responsible for its degradation in vivo.

AC-SER-ASP-LYS-PRO-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-SER-ASP-LYS-PRO-OH Suppliers

China 115 Germany 1 India 1 Poland 1 Switzerland 1 United Kingdom 2 United States 14 Global 135
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View Lastest Price from AC-SER-ASP-LYS-PRO-OH manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Goralatide 127103-11-1
Price
US $30.00/box
Min. Order
1box
Purity
98%
Supply Ability
2000kg
Release date
2024-03-21
Shanghai Getian Industrial Co., LTD
Product
AC-SER-ASP-LYS-PRO-OH 127103-11-1
Price
US $25.00-20.00/box
Min. Order
1box
Purity
99%
Supply Ability
100000box
Release date
2024-05-17
zhuzhou dingcheng meihei comestic co.,ltd
Product
Thymosin β4 (1-4) 127103-11-1
Price
US $30.00/Box
Min. Order
1Box
Purity
99.99%
Supply Ability
10000000000
Release date
2023-12-20

127103-11-1, AC-SER-ASP-LYS-PRO-OHRelated Search:

ARG-PRO-PRO-GLY-PHE-SER-PRO-LEU PYR-HIS-TRP-SER-TYR-GLY-TRP-LEU-PRO-GLY-NH2 H-ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN-OH ALA-D-GAMMA-GLU-LYS-D-ALA-D-ALA LHRH Goserelin Gonadorelin Gonadorelin impurity Fluralaner

  • SERASPENIDE
  • ACETYL-SER-ASP-LYS-PRO
  • AC-SDKP
  • AC-SDKP-DELTA
  • AC-SER-ASP-LYS-PRO
  • AC-SER-ASP-LYS-PRO-OH
  • AcSDKP Ac-Ser-Asp-Lys-Pro
  • REF DUPL: Ac-Ser-Asp-Lys-Pro-OH
  • AcSDKP, SteM Cell Proliferation Inhibitor, Goralatide, ThyMosin b4 (1-4)
  • Acetyl-SDKP
  • Thymosin β4 (1-4)
  • Ac-L-Ser-L-Asp-L-Lys-L-Pro-OH
  • N-Acetyl-Ser-Asp-Lys-Pro-OH
  • N-Ac-Ser-Asp-Lys-Pro-OH
  • Acetyl-serinyl-aspartyl-lysinyl-proline
  • GORALATIDE
  • L-Proline, N-acetyl-L-seryl-D-α-aspartyl-L-lysyl-
  • AC-SER-ASP-LYS-PRO-OH USP/EP/BP
  • 1-[2-[[2-[(2-acetamido-3-hydroxypropanoyl)amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylic acid
  • Thymosin β4 (1-4)
  • Ac-Ser-Asp-Lys-Pro-OH (H-1156.0005)
  • Ac-SDKP,NAcetylSerAspLysPro,Inhibitor,inhibit,N Acetyl Ser Asp Lys Pro,Angiotensin-converting Enzyme (ACE)
  • Thymosin beta4 (1-4)
  • AC-SER-ASP-LYS-PRO-O
  • 127103-11-1
  • C20H33N5O9
  • Peptides
  • BioChemical
  • Angiotensins
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • Peptide
  • Angiotensins
  • Peptides for Cell Biology