Methyl p-toluenesulfonate

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Methyl p-toluenesulfonate

Product Name: Methyl p-toluenesulfonate
CAS No.: 80-48-8
Chemical Name: Methyl p-toluenesulfonate
Synonyms: Methyl 4-methylbenzenesulfonate;MPTS;METHYL TOSYLATE;METHYL TOLUENE-4-SULPHONATE;PTSME;METHYL P-TOSYLATE;Methyl para-toluenesulfonate;4-TOLUENESULFONIC ACID METHYL ESTER;4-methyl-benzenesulfonicacimethylester;Benzenesulfonicacid,4-methyl-,methylester
CBNumber: CB8715537
Molecular Formula: C8H10O3S
Formula Weight: 186.23
MOL File: 80-48-8.mol

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Methyl p-toluenesulfonate Property

Melting point:: 25-28 °C(lit.)
Boiling point:: 144-145 °C5 mm Hg(lit.)
Density: 1.234 g/mL at 25 °C(lit.)
vapor density: 6.45 (vs air)
vapor pressure: 1 mm Hg ( 20 °C)
refractive index: n20/D 1.5172(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid or Low Melting Solid
color: White to yellow
Water Solubility: Insoluble
Sensitive: Moisture Sensitive
BRN: 609209
LogP: 1.88 at 25℃
CAS DataBase Reference: 80-48-8(CAS DataBase Reference)
NIST Chemistry Reference: Benzenesulfonic acid, 4-methyl-, methyl ester(80-48-8)
EPA Substance Registry System: Benzenesulfonic acid, 4-methyl-, methyl ester (80-48-8)

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Safety

Hazard Codes: C,Xn
Risk Statements: 22-34-43-40-36/37/38
Safety Statements: 26-36/37/39-45-24
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
RTECS: XT7000000
F: 21
Autoignition Temperature: 896 °F
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29051900
Hazardous Substances Data: 80-48-8(Hazardous Substances Data)
Toxicity: LD50 orally in Rabbit: 341 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.08333
Product name: Methyl-4-toluenesulfonate
Purity: for synthesis
Packaging: 100g
Price: $36.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08333
Product name: Methyl-4-toluenesulfonate
Purity: for synthesis
Packaging: 500g
Price: $104
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08333
Product name: Methyl-4-toluenesulfonate
Purity: for synthesis
Packaging: 2.5kg
Price: $383
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08333
Product name: Methyl-4-toluenesulfonate
Purity: for synthesis
Packaging: 25kg
Price: $1130
Updated: 2024/03/01

Sigma-Aldrich

Product number: 158992
Product name: Methyl p-toluenesulfonate
Purity: 98%
Packaging: 100g
Price: $41.9
Updated: 2024/03/01

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Methyl p-toluenesulfonate Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellow low melting solid. Soluble in alcohol, ether, benzene, insoluble in water. Hygroscopic.

Uses

Methyl p-toluenesulfonate is used as a methylating agent in organic synthesis. It acts as a catalyst for alkyd resins. It is also employed in selective 1-substitution reaction of tetrazole. Further, it is used in the preparation of dyes.

Uses

Methyl p-Toluenesulfonate can be used in the manufacture of dyes and organic synthesis, and also is the raw materials of methylation.

Preparation

Methyl p-toluenesulfonate was synthesized by the reaction of p-toluenesulfonyl chloride with methanol. Mix p-toluenesulfonyl chloride and methanol, slowly add 25% sodium hydroxide solution, control the temperature below 25 °C, stop adding alkali when the pH is 9, continue stirring for 2 hours, and leave overnight. The lower layer of reactant was taken, the upper layer was extracted with benzene, the extract was recovered with benzene and then combined with the lower layer, washed with water and 5% potassium carbonate solution in turn, dried and distilled under reduced pressure to obtain the finished product of methyl p-toluenesulfonate.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 29, p. 623, 1981 DOI: 10.1248/cpb.29.623
Synthetic Communications, 15, p. 1057, 1985 DOI: 10.1080/00397918508076842

General Description

Methyl p-toluenesulfonate is sulfonate ester present as potentially genotoxic impurity in drug substances. Kinetics of reactions of methyl p-toluenesulfonate with N,N-dimethylaniline has been investigated. It participates in selective 1-substitution reaction of tetrazole.

Hazard

Toxic by ingestion and inhalation, strongirritant to skin and eyes.

Safety Profile

Poison by ingestion and subcutaneous routes. An eye and severe skin irritant. A vesicant and skin sensitizer. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of SOx.

Purification Methods

The ester is purified by distillation in vacuo and could be crystallised from pet ether or Et2O/pet ether at low temperature. It is a powerful methylating agent, is TOXIC andis a skin irritant, so it is better to purify it by repeated distillation. [IR: Schreiber Anal Chem 21 1168 1949, Buehler et al. J Org Chem 2 167 1937, Roos et al. Org Synth Coll Vol I 145 1948, Beilstein 11 IV 247.]

Methyl p-toluenesulfonate Preparation Products And Raw materials

Raw materials

Tosyl chloride

Preparation Products

1,3,3-Trimethyl-2-methyleneindoline 5-BROMO-1,2-DIMETHYL-1H-IMIDAZOLE

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View Lastest Price from Methyl p-toluenesulfonate manufacturers

Jinan Finer Chemical Co., Ltd

Product: Methyl p-toluenesulfonate 80-48-8
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000mt/year
Release date: 2021-08-31

Hong Kong Excellence Biotechnology Co., Ltd.

Product: Methyl p-toluenesulfonate 80-48-8
Price: US $100.00/kg
Min. Order: 1kg
Purity: >99%
Supply Ability: 50 TONS
Release date: 2023-10-08

Shanghai Aosiris new Material Technology Co., LTD

Product: Methyl p-toluenesulfonate 80-48-8
Price: US $3.00-1.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10 tons
Release date: 2024-03-12

80-48-8, Methyl p-toluenesulfonateRelated Search:

Paraquat dichloride Acetonitrile Methyl acrylate Methanol Kresoxim-methyl Basic Violet 1 Iron(III) p-toluenesulfonate p-Toluenesulfonic acid Sorafenib tosylate 4-Nitrotoluene-2-sulfonic Acid Methyl benzenesulfonate 4-CHLOROBENZOYLACETONITRILE Ethyl p-toluenesulfonate Sodium p-toluenesulfonate Methyl acetate Methylparaben 2,5-Dioxopyrrolidin-1-yl 3-methoxypropanoate Methyl

4-methyl-benzenesulfonicacimethylester

Benzenesulfonicacid,4-methyl-,methylester

Methyl 4-methylbenzenesulfonate

Methyl ester of 4-methylbenzenesulfonic acid

Methyl para-toluenesulfonate

p-toluenesulfonatedemethyle

p-Toluolsulfonsaeure methyl ester

p-toluolsulfonsaeuremethylester

p-Tolylmethylsulfonate

Toluene-4-sulfonicacidmethylester

MPTS

MPTS, TRISODIUM SALT

P-TOLUENESULFONIC ACID METHYL ESTER

PTS1

TRISODIUM-8-METHOXYPYRENE-1,3,6-SULFONATE

TRISODIUM 8-METHOXYPYRENE-1,3,6-TRISULFONATE

P-Toluene sulfonic acid Methyl Ester, PTSM, Methyl p-toluenesulfonate, P-Toluenesulfonic acid Methyl Ester

Methyl p-methylbenzenesulfonate

Methyl toluene-4-sulfonate

methyl4-methylbenzenesulfonate

Methylester kyseliny p-toluensulfonove

methylesterkyselinyp-toluensulfonove

methylesterkyselinyp-toluensulfonove(czech)

methylp-methylbenzenesulfonate

methyltoluene-4-sulfonate

p-Methylbenzenesulfonate methyl ester

p-methylbenzenesulfonatemethylester

8-METHOXYPYRENE-1,3-6-TRISULFONIC ACID TRISODIM SALT

4-methylbenzenesulfonic acid methyl ester

4-TOLUENESULFONATE METHYL ESTER

4-TOLUENESULFONIC ACID METHYL ESTER

METHYL 4-TOLUENESULFONATE

LABOTEST-BB LT00782089

METHYL P-TOLUENESULPHONATE

METHYL P-TOLUENESULFONATE

METHYL P-TOSYLATE

METHYL TOLUENE-4-SULPHONATE

METHYL TOSYLATE

p-Toluenesulfonic acid mehtyl ester

Methyl-4-toluenesulphonate

MethylP-Toluenesulphonate~97%

Methylp-toluenesulfonate,98%

METHYLPARA-TOLUENESULPHONATE

PARA-TOLUENEMETHYLSULPHONATE

PARA-TOLUENESULPHONICACID,METHYLESTER

METHYL-4-TOLUENESULFONATE 99%

Methyl p-tosylate~p-Toluenesulphonic acid methyl ester

P-Toluene sulPhonic acid methyl ester

4-Methylbenzenesulfonic acid methyl

Methanol tosylate

p-Toluenesulfonic acid methyl

Methyl p-toluenesulfonate,97%

Methyl p-toluenesulf

Methyl 4-methylbenzenesulphonate, Methyl tosylate

Methyl toluene-4-sulphonate 98%

Methyl p-toluenesulfonate, 97% 100GR

Methyl p-toluenesulfonate, 97% 500GR

METHYL 4-TOLUENESULFONATE FOR SYNTHESIS