4,5-DIBROMO-O-XYLENE

Product Name: 4,5-DIBROMO-O-XYLENE
CAS No.: 24932-48-7
Chemical Name: 4,5-DIBROMO-O-XYLENE
Synonyms: 1,2-DIBROMO-4,5-DIMETHYLBENZENE;4,5-DIBROMO-O-XYLENE;4,5-Dibromo-2-methyl-toluene;2-Dibromo-4,5-dimethylbenzene;1,2-DiMethyl-4,5-dibroMobenzene;4,5-DIBROMO-1,2-DIMETHYLBENZENE;Benzene, 1,2-dibromo-4,5-dimethyl-;1,2-Dibromo-4,5-dimethylbenzene >1,2-Dibromo-4,5-dimethylbenzene 98+%;4,5-DIBROMO-O-XYLENE ISO 9001：2015 REACH
CBNumber: CB8719429
Molecular Formula: C8H8Br2
Formula Weight: 263.96
MOL File: 24932-48-7.mol

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4,5-DIBROMO-O-XYLENE Property

Melting point:: 85-89 °C (lit.)
Boiling point:: 278 °C
Density: 1.7485 (rough estimate)
refractive index: 1.6146 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Pale Yellow
BRN: 2206183
InChI: InChI=1S/C8H8Br2/c1-5-3-7(9)8(10)4-6(5)2/h3-4H,1-2H3
InChIKey: BCIDDURGCAHERU-UHFFFAOYSA-N
SMILES: C1(Br)=CC(C)=C(C)C=C1Br
CAS DataBase Reference: 24932-48-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 638447
Product name: 1,2-Dibromo-4,5-dimethylbenzene
Purity: 97%
Packaging: 5g
Price: $147
Updated: 2025/07/31

Sigma-Aldrich

Product number: 638447
Product name: 1,2-Dibromo-4,5-dimethylbenzene
Purity: 97%
Packaging: 1g
Price: $54.4
Updated: 2023/06/20

TCI Chemical

Product number: D2272
Product name: 1,2-Dibromo-4,5-dimethylbenzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $119
Updated: 2025/07/31

TCI Chemical

Product number: D2272
Product name: 1,2-Dibromo-4,5-dimethylbenzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $393
Updated: 2025/07/31

Biosynth Carbosynth

Product number: FD33412
Product name: 4,5-Dibromo-o-xylene
Packaging: 25g
Price: $712.5
Updated: 2021/12/16

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4,5-DIBROMO-O-XYLENE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

1,2-Dibromo-4,5-dimethylbenzene is used as a reagent in the synthesis of Thalidomide (T338850); an inhibitor of FGF-induced angiogenesis and replication of human immunodeficiency virus type 1. Also a teratogenic sedative and immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.

Uses

1,2-Dibromo-4,5-dimethylbenzene can be used in the synthesis of alkylamino zinc(II)phthalocyanines, with potential application as photosensitizers in photodynamic therapy. It can also be used in the synthesis of 1,2-dibromo-4,5-bis(dibromomethyl)benzene via reaction with azobisisobutyronitrile.

General Description

1,2-Dibromo-4,5-dimethylbenzene can be synthesized via bromination of o-xylene.

Synthesis

95-47-6

24932-48-7

The general procedure for the synthesis of 1,2-dibromo-4,5-dimethylbenzene from o-xylene was as follows: 1-methoxy-3,5-dimethylbenzene (100 mg, 0.73 mmol), N-bromosuccinimide (NBS, 260 mg, 1.46 mmol), and a stainless steel ball (5 mm in diameter) were placed in a 10 mL stainless steel grinding jar. The ball milling reaction was carried out and the progress of the reaction was monitored by thin layer chromatography (TLC) and proton nuclear magnetic resonance (1H NMR). Upon completion of the reaction, the reaction mixture was transferred to 30 mL of ethyl acetate and cooled at 0 °C. The product in the filtrate and the precipitated spent succinimide were separated by filtration through filter paper. The filtrate was concentrated under vacuum to give 250 mg (85% yield) of 1,2-dibromo-4,5-xylene (2b) as a colorless powder. To test the efficiency of the large-scale reaction, a monobromination reaction with 1.3 g of 1-methoxy-3,5-dimethylbenzene was also carried out for a reaction time of 1 h. The product was isolated in 87% yield. During the reaction, the grinding equipment was suspended and a small sample was removed from the reaction tank for TLC and 1H NMR analysis, after which the reaction was continued, and the time of this operation was not included in the total reaction time.

References

[1] Tetrahedron, 2002, vol. 58, # 46, p. 9413 - 9422
[2] Tetrahedron Letters, 2014, vol. 55, # 13, p. 2154 - 2156
[3] Tetrahedron Letters, 2015, vol. 55, # 13, p. 2154 - 2156
[4] Journal of the American Chemical Society, 1993, vol. 115, # 13, p. 5422 - 5429
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 1, p. 227 - 231

4,5-DIBROMO-O-XYLENE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5-DIBROMO-O-XYLENE Suppliers

Americas 1 China 136 Europe 1 Germany 2 India 7 Japan 1 Switzerland 1 United Kingdom 10 United States 16 Global 175

Chongqing Chemieliva Pharmaceutical Co., Ltd.

Tel: 18696571988
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Energy Chemical

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View Lastest Price from 4,5-DIBROMO-O-XYLENE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4,5-DIBROMO-O-XYLENE 24932-48-7
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-26

Career Henan Chemical Co

Product: 4,5-DIBROMO-O-XYLENE 24932-48-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 40%-99%
Supply Ability: 1000kg
Release date: 2018-08-20

24932-48-7, 4,5-DIBROMO-O-XYLENERelated Search:

BROMOSULFALEIN Sulfobromophthalein sodium 2-(2-hydroxyethoxy)ethyl 2-hydroxypropyl 3,4,5,6-tetrabromophthalate 3,4,5,6-TETRABROMOPHTHALIMIDE 1,2-DIBROMO-3,4,5,6-TETRAMETHYLBENZENE Tetrabromophthalic anhydride 4,5-DIBROMO-O-XYLENE 1,2-Bis(tetrabromophthalimido) ethane 4,5,6,7-TETRABROMOPHENOLPHTHALEIN ALPHA,ALPHA'-DIBROMO-M-XYLENE,à,à'-dibromo-m-xylene,alpha,alpha'-Dibromo-meta-xylene,α,α’-dibromo-m-xylen alpha,alpha'-Dibromo-p-xylene 2,5-DIBROMO-P-XYLENE, 98+%,2,5-DIBROMO-P-XYLENE,2,5-DIBROMO-4-XYLENE alpha,alpha '-Dibromo-ortho-xylene,α,α’-dibromo-o-xylen alpha-Dibromo-m-xylene TETRABROMOPHTHALIC ACID 3,4,5,6-TETRABROMO-O-XYLENE bis(2-ethylhexyl) tetrabromophthalate ALPHA,ALPHA,ALPHA',ALPHA',4,5-HEXABROMO-O-XYLENE

1,2-DIBROMO-4,5-DIMETHYLBENZENE

4,5-DIBROMO-O-XYLENE

4,5-DIBROMO-1,2-DIMETHYLBENZENE

1,2-Dibromo-4,5-dimethylbenzene 98+%

2-Dibromo-4,5-dimethylbenzene

1,2-DiMethyl-4,5-dibroMobenzene

1,2-Dibromo-4,5-dimethylbenzene &gt

Benzene, 1,2-dibromo-4,5-dimethyl-

4,5-DIBROMO-O-XYLENE ISO 9001：2015 REACH

4,5-Dibromo-2-methyl-toluene

24932-48-7

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