6-FLUOROQUINOLINE-2-CARBOXALDEHYDE
- Product Name
- 6-FLUOROQUINOLINE-2-CARBOXALDEHYDE
- CAS No.
- 260430-93-1
- Chemical Name
- 6-FLUOROQUINOLINE-2-CARBOXALDEHYDE
- Synonyms
- 6-FLUOROQUINOLINE-2-CARBALDEHYDE;6-Fluoro-2-quinolinecarboxaldehyde;6-FLUOROQUINOLINE-2-CARBOXALDEHYDE;6-Fluoroquinoline-2-carbaldehyde 97%;2-Quinolinecarboxaldehyde, 6-fluoro-;6-Fluoroquinoline-2-carboxaldehyde,97%;6-fluoroquinoline-2-carbaldehyde(SALTDATA: FREE);6-
Fluoroquinoline- 2- carboxaldehyde - CBNumber
- CB8721431
- Molecular Formula
- C10H6FNO
- Formula Weight
- 175.16
- MOL File
- 260430-93-1.mol
6-FLUOROQUINOLINE-2-CARBOXALDEHYDE Property
- Melting point:
- 113-120℃
- Boiling point:
- 318.0±22.0 °C(Predicted)
- Density
- 1.320±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- Solid
- pka
- 2.98±0.43(Predicted)
- Appearance
- Light yellow to brown Solid
- Sensitive
- Moisture Sensitive
- InChI
- InChI=1S/C10H6FNO/c11-8-2-4-10-7(5-8)1-3-9(6-13)12-10/h1-6H
- InChIKey
- JDQMJKKGPXPPOJ-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(F)=CC=2)C=CC=1C=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 774480
- Product name
- 6-Fluoroquinoline-2-carboxaldehyde
- Purity
- 96%
- Packaging
- 1g
- Price
- $71.06
- Updated
- 2025/07/31
- Product number
- B440760
- Product name
- 6-fluoroquinoline-2-carbaldehyde
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 093671
- Product name
- 6-Fluoroquinoline-2-carbaldehyde
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- 093671
- Product name
- 6-Fluoroquinoline-2-carbaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $639
- Updated
- 2021/12/16
- Product number
- HCH0089425
- Product name
- 6-FLUOROQUINOLINE-2-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $952.01
- Updated
- 2021/12/16
6-FLUOROQUINOLINE-2-CARBOXALDEHYDE Chemical Properties,Usage,Production
Synthesis
1128-61-6
260430-93-1
General procedure for the synthesis of 6-fluoroquinoline-2-carbaldehyde from 6-fluoro-2-methylquinoline: a mixture of compound 6 (0.48 g, 3.0 mmol) with selenium dioxide (0.66 g, 6.0 mmol) in 1,4-dioxane (50 mL) was heated and reacted for 2 hr at 100 °C (the reaction progress was monitored by TLC). Upon completion of the reaction, the mixture was cooled and treated with 5% aqueous NaHCO3 (80 mL) followed by extraction with dichloromethane (50 mL x 3). The organic layers were combined and dried with anhydrous magnesium sulfate, followed by evaporation of the solvent. The crude product was crystallized by ethanol to give compound 7 (0.43 g, 81% yield) as a white solid. Next, compound 7 (0.36 g, 2.0 mmol) was stirred with the corresponding acetophenone (2.0 mmol) at 0 °C for 15 min. Six equivalents of aqueous KOH solution was added and the reaction mixture was stirred at room temperature for 12 hours (the progress of the reaction was monitored by TLC). After completion of the reaction, the reaction mixture was adjusted to pH 3 by adding 1 M HCl to the reaction mixture and extracted with ethyl acetate (50 mL x 3). The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated in vacuum. The crude products were obtained as quinolinyl chalcone derivatives 8a-c by purification and crystallization with ethanol.
References
[1] Heterocycles, 2000, vol. 53, # 1, p. 37 - 48
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 24, p. 8663 - 8678
[3] European Journal of Medicinal Chemistry, 2017, vol. 141, p. 282 - 292
[4] Patent: TW2018/6938, 2018, A. Location in patent: Paragraph 0027; 0028
[5] Patent: CN106083713, 2016, A. Location in patent: Paragraph 0060-0062
6-FLUOROQUINOLINE-2-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
6-FLUOROQUINOLINE-2-CARBOXALDEHYDE Suppliers
- Tel
- 19951323309
- 1158718798@qq.com
- Country
- China
- ProdList
- 292
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0519-89803565 13776850645
- Fax
- 0519-89803575
- info4@huanlingchem.com
- Country
- China
- ProdList
- 891
- Advantage
- 68
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- 15528092102
- Fax
- On Line QQ 2415375924
- Pharmsynth@hotmail.com
- Country
- China
- ProdList
- 116
- Advantage
- 60
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 13052276172
- Fax
- 13052276172
- product@yuyuanpharm.com
- Country
- China
- ProdList
- 493
- Advantage
- 55
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- sales@ahpharmatech.com
- Country
- China
- ProdList
- 5734
- Advantage
- 55
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-20432229
- Fax
- QQ2412110556
- 2412110556@qq.com
- Country
- China
- ProdList
- 6017
- Advantage
- 55
- Tel
- +86-0838-2319818 +86-15982001943
- seniorpharma@163.com
- Country
- China
- ProdList
- 446
- Advantage
- 55
- Tel
- 028-64971018 18108168130
- Fax
- 86 028-64971018
- Country
- China
- ProdList
- 1781
- Advantage
- 55
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 13933818572
- Fax
- 0311-82870388
- 1519554262@qq.com
- Country
- China
- ProdList
- 1785
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 0371-0371-61318675 17719817155
- Fax
- 0371-61318675
- sales@xlinebio.com
- Country
- China
- ProdList
- 2857
- Advantage
- 58
- Tel
- 0371-037163312495,13303845143 13303845143
- Fax
- QQ3001379618
- 3001379618@qq.com
- Country
- China
- ProdList
- 10267
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12878
- Advantage
- 58
- Tel
- 15001899038 15001899038;
- wenjiayiyao@126.com
- Country
- China
- ProdList
- 996
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- 0512-65816829 18662214788
- Fax
- 0512-65816829
- info@rovathin.com.cn
- Country
- China
- ProdList
- 9987
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +86-400-0216110 +86-15958047586
- Fax
- 0086-21-33275002
- sales@allfluoro.com
- Country
- China
- ProdList
- 11385
- Advantage
- 58
- Tel
- 027-888-4366503
- Fax
- 888-502-1736
- sales@amelpharmatech.com
- Country
- China
- ProdList
- 5000
- Advantage
- 58
- Tel
- 021-50895067 18616507272
- Fax
- 021-50895067
- tensus@163.com
- Country
- China
- ProdList
- 8073
- Advantage
- 58
- Tel
- 18616526224
- lianshuo@vip.126.com
- Country
- China
- ProdList
- 9607
- Advantage
- 58
- Tel
- 021-13472633-721 13472633721
- 454407203@qq.com
- Country
- China
- ProdList
- 552
- Advantage
- 58
- Tel
- 0512-65885589 18751140360
- Fax
- 0512-65885589
- sales@rosen-chemicals.com
- Country
- China
- ProdList
- 292
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- +8613580539051
- joe@yuhengpharm.com
- Country
- CHINA
- ProdList
- 21142
- Advantage
- 58
- Tel
- nanfengdrug@163.com; 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20009
- Advantage
- 58
- Tel
- 17625585511
- Fax
- qq：1580084073
- 1580084073@qq.com
- Country
- China
- ProdList
- 959
- Advantage
- 58
- Tel
- 0371-0371-53736046 13393710386
- Fax
- QQ:2853979814
- 2853979814@qq.com
- Country
- China
- ProdList
- 9947
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 021-61109150
- Fax
- 021-61105897
- sales@tcisct.com
- Country
- China
- ProdList
- 29668
- Advantage
- 58
- Tel
- 0574-87314919 057487319282
- info@nbinno.com
- Country
- China
- ProdList
- 7047
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62220
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- 1173954148q
- meishipharma@126.com
- Country
- China
- ProdList
- 20033
- Advantage
- 58
- Tel
- 13417589054;
- trendseenbio@gmail.com
- Country
- China
- ProdList
- 9069
- Advantage
- 58
- Tel
- 0533-6092686 13371592196
- ddliu@bio-polar.cn
- Country
- China
- ProdList
- 2229
- Advantage
- 58
- Tel
- 16696119288
- 779113375@qq.com
- Country
- China
- ProdList
- 7237
- Advantage
- 58
- Tel
- 15021035486 18081542813
- 1804873256@qq.com
- Country
- China
- ProdList
- 6684
- Advantage
- 58
- Tel
- 18151111370
- 1046215251@qq.com
- Country
- China
- ProdList
- 8718
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58