Anagrelide hydrochloride
- Product Name
- Anagrelide hydrochloride
- CAS No.
- 58579-51-4
- Chemical Name
- Anagrelide hydrochloride
- Synonyms
- ANAGRELIDE HCL;AGRYLIN;RL 603;Xagrid;Agrelin;BL-4162A;BMY-26538-01;Agryline,HCl;TroMboreductin;Xagrid hydrochloride
- CBNumber
- CB8722913
- Molecular Formula
- C10H8Cl3N3O
- Formula Weight
- 292.55
- MOL File
- 58579-51-4.mol
Anagrelide hydrochloride Property
- Melting point:
- >280°C
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble1mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 58579-51-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H351Suspected of causing cancer
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0846
- Product name
- Anagrelide hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- SML0846
- Product name
- Anagrelide hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $478
- Updated
- 2024/03/01
- Product number
- 21411
- Product name
- Anagrelide (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 21411
- Product name
- Anagrelide (hydrochloride)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $261
- Updated
- 2024/03/01
- Product number
- 21411
- Product name
- Anagrelide (hydrochloride)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $456
- Updated
- 2024/03/01
Anagrelide hydrochloride Chemical Properties,Usage,Production
Description
Anagrelide hydrochloride was launched in the US for thrombocytosis (essential or associated with chronic myelogenous leukemia). The imidazoquinazoline derivative can be prepared from 2,5,6-trichloro-3,4-dihydropyrimidine via alkylation with ethyl bromoacetate followed by heating with ethanolic ammonia or treatment of N-(a-amino- 5,6-dichlorobenzyl)glycine ethyl ester with cyanogen bromide. As a result of its anti-cAMP phosphodiesterase (PDE Ⅲ) activity, Anagrelide hydrochloride was initially tested as a platelet aggregation inhibitor. However it was found that at much lower concentrations it became thrombocytopenic. While the mechanism is not fully understood, it did not shorten platelet survival nor inhibit the formation of colony-forming unitsmegakaryocytes (CFU-M) but primarily interfered with the maturation of megakaryocytes (reduction in size with altered ploidy). It did decrease peripheral vascular resistance and had a positive inotropic effect.
Chemical Properties
Off-White Powder
Originator
Roberts (US)
Uses
Signal Transduction Agents, Potent PDE3 inhibitor
Uses
Anagrelide Hydrochloride is a phosphodiesterase inhibitor with antiplatelet activity. Used as an antithrombocythemic. Potent PDE3 inhibitor.
Definition
ChEBI: The hydrochloride salt of anagrelide.
Manufacturing Process
6,7-Dicloro-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one was produced
from 6-chloro-7-bromo-1,2,3,5-tetrahydroimidazo[2,1-b]quinozolin-2-one by
substitution the bromine an equimolar quantity chlorine.
6-Chloro-7-bromo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one was
produced next way: to a solution of 1.30 g (8 mmole) of anhydrous ferric
chloride in 30 ml of nitromethane was added 1.30 g (5 mmole) of solid 6-
chloro-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one and 0.80 g (5
mmole) of bromine. The system was stoppered, warmed to 50°C in an oil
bath overnight, cooled to room temperature and the solvent removed in
vacuo. The resulting solid was suspended in water (50 ml), the mixture was
made basic (pH=10) with sodium bicarbonate and stirred at home
temperature for 20 min. The solid was filtered under suction, washed with
water, then isopropyl alcohol and dried yielding 1.19 g of 6-chloro-7-bromo-
1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one (78% yield). Purification
was effected by formation of the hydrochloride salt (mp 275°C) from
acetonitrile.
6-Chloro-1,2,3,5,-tetrahydroimidazo[2,1-b]quinazolin-2-one was produced
from 6-chloro-2-nitrobenzylchloride, ethylglycine hydrochloride and cyanogen
bromide in 3 steps.
brand name
Agrylin (Shire).
Therapeutic Function
Platelet aggregation inhibitor
General Description
Anagrelide belongs to the imidazo[2,1-b]quinazolin-2-one series of compounds.
Biological Activity
Potent type III phosphodiesterase (PDE3) inhibitor (IC 50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.
Biochem/physiol Actions
Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity (IC50 = 36 nM for inhibition of phosphodiesterase-III). Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. As a drug, anagrelide is antithrombocythemic used for the treatment of overproduction of blood platelets.
References
1) Gilespie?et al.?(1988),?Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity; Biochem. Pharmacol.?37?2866 2) Mazur?et al.?(1992),?Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans; Blood,?79?1931 3) Wang?et al.?(2005),?Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures; Br. J. Pharmacol.,?146?324 4) Barbui?et al.?(2012),?Front-line therapy in polycythemia vera and essential thrombocythemia; Blood Rev.,?26?205 5) Chen?et al.?(2012),?Platelet-lowering therapy with anagrelide as an adjuvant therapy for treatment of primary pulmonary neoplasm-associated extreme thrombocytosis; Jpn. J. Clin. Oncol.,?42?761
Anagrelide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Anagrelide hydrochloride manufacturers
- Product
- Anagrelide hydrochloride 58579-51-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99% HPLC
- Supply Ability
- 2000tons
- Release date
- 2019-12-30
- Product
- Anagrelide hydrochloride 58579-51-4
- Price
- US $0.00/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2019-10-29
- Product
- Anagrelide hydrochloride 58579-51-4
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24