ChemicalBook > CAS DataBase List > BIS(2,2,2-TRIFLUOROETHYL) ETHER

BIS(2,2,2-TRIFLUOROETHYL) ETHER

Product Name
BIS(2,2,2-TRIFLUOROETHYL) ETHER
CAS No.
333-36-8
Chemical Name
BIS(2,2,2-TRIFLUOROETHYL) ETHER
Synonyms
HFE;SF6539;SKL232;Idoklon;skf6539;Flurotyl;Indiklon;Indoklon;SKF 6539;SK&F-6539
CBNumber
CB8723208
Molecular Formula
C4H4F6O
Formula Weight
182.06
MOL File
333-36-8.mol
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BIS(2,2,2-TRIFLUOROETHYL) ETHER Property

Melting point:
25°C
Boiling point:
62-63 °C (lit.)
Density 
1.404 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.300(lit.)
Flash point:
35 °F
storage temp. 
Flammables area
solubility 
DMSO : ≥ 125 mg/mL (686.59 mM)
form 
clear liquid
color 
Colorless to Almost colorless
Specific Gravity
1.41
Merck 
14,4201
BRN 
1811927
CAS DataBase Reference
333-36-8(CAS DataBase Reference)
EPA Substance Registry System
HFE-356mff2 (333-36-8)
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Safety

Hazard Codes 
F,Xi,T
Risk Statements 
11-36/37/38
Safety Statements 
16-26-36
RIDADR 
UN 3271 3/PG 2
WGK Germany 
3
RTECS 
KN3675000
Hazard Note 
Flammable/Toxic/Convulsant
HazardClass 
3.1
PackingGroup 
II
HS Code 
29091990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
287571
Product name
Bis(2,2,2-trifluoroethyl) ether
Purity
98%
Packaging
5g
Price
$113
Updated
2024/03/01
TCI Chemical
Product number
B1293
Product name
Bis(2,2,2-trifluoroethyl) Ether
Purity
>99.0%(GC)
Packaging
1g
Price
$59
Updated
2024/03/01
TCI Chemical
Product number
B1293
Product name
Bis(2,2,2-trifluoroethyl) Ether
Purity
>99.0%(GC)
Packaging
5g
Price
$163
Updated
2024/03/01
TRC
Product number
B585665
Product name
Bis(2,2,2-trifluoroethyl) Ether
Packaging
500mg
Price
$70
Updated
2021/12/16
TRC
Product number
B585665
Product name
Bis(2,2,2-trifluoroethyl) Ether
Packaging
1g
Price
$120
Updated
2021/12/16
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BIS(2,2,2-TRIFLUOROETHYL) ETHER Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Originator

Indoklon ,Ohio Medical, US ,1964

Uses

Bis(2,2,2-trifluoroethyl) ether was used to diminish self-discharge of Li-S cells having both low- and high-sulfur-loading sulfur cathodes.

Uses

Bis(2,2,2-trifluoroethyl) Ether is Prophylactic and/or therapeutic agent for Alzheimer''s disease.

Uses

5HT agonist

Definition

ChEBI: Flurotyl is an ether.

Manufacturing Process

23 parts of sodium metal were placed in 300 parts of dry dioxane in a reactor equipped with an agitator and reflux condenser. The dioxane was heated to reflux while stirring.150 parts of 2,2,2-trifluoroethanol were added very slowly in the period of about 1 hour, or until the sodium was all reacted, to form sodium 2,2,2-trifluoroethylate. 250 parts of 2,2,2-trifluoroethyl ptoluenesulfonate prepared by reacting 2,2,2-trifluoroethanol with p Flurothyl toluenesulfonyl chloride were placed in another reactor and heated to about 160° to 185°C. The solution of sodium 2,2,2-trifluoroethylate in dioxane was added very slowly over a period of about 1? hours. Bis(2,2,2-trifluoroethyl) ether formed continuously and distilled from the reactor with the dioxane into a cooled receiving vessel. The condensed effluent from the reactor was fractionally distilled, yielding 46.5 parts of products boiling at 55° to 73°C.
The crude product was washed successively with concentrated HCl, 62% H2SO4,concentrated H2SO4 and 5% NaOH solution. It was dehydrated over a drying agent and then refractionated in a still. 20 parts of bis(2,2,2trifluoroethyl) ether were recovered (BP 62.5° to 63.5°C).

brand name

Indoklon (Ohmeda).

Therapeutic Function

Central stimulant, Convulsant

BIS(2,2,2-TRIFLUOROETHYL) ETHER Preparation Products And Raw materials

Raw materials

Preparation Products

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BIS(2,2,2-TRIFLUOROETHYL) ETHER Suppliers

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View Lastest Price from BIS(2,2,2-TRIFLUOROETHYL) ETHER manufacturers

Henan Fengda Chemical Co., Ltd
Product
Fluorothyl 333-36-8
Price
US $30.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-26
Henan Aochuang Chemical Co.,Ltd.
Product
BIS(2,2,2-TRIFLUOROETHYL) ETHER 333-36-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08

333-36-8, BIS(2,2,2-TRIFLUOROETHYL) ETHERRelated Search:


  • Di(2,2,2-trifluroethyl)ether
  • Bis(2,2,2-trifluoroethyl) ether 99%
  • Bis(2,2,2-trifluoroethyl)ether99%
  • 2,2,2-TRIFLUOROETHYL ETHER 99%
  • 2,2,2-Trifluoroethyl ether, Flurothyl
  • 1,1'-Oxybis(2,2,2-trifluoroethane)
  • 2,2,2-Trifluoroethyl ether,99%
  • 1,1,1-Trifluoro-2-(2,2,2-trifluoroethoxy)ethane
  • 2-(2,2,2-Trifluoroethoxy)-1,1,1-trifluoroethane
  • Bis(trifluoroethyl)ether
  • Ethane, 1,1'-oxybis[2,2,2-trifluoro-
  • Ether, bis(2,2,2-trifluoroethyl)
  • ether,bis(2,2,2-trifluoroethyl)
  • Fluoroethyl
  • Fluorothyl
  • Flurotyl
  • Hexafluorodiethyl ether
  • hexafluorodiethylether
  • HFE
  • Idoklon
  • Indiklon
  • Indoklon
  • SF6539
  • SK&F-6539
  • SKF 6539
  • skf6539
  • 2,2,2-TRIFLUOROETHYL ETHER
  • BIS(2,2,2-TRIFLUOROETHYL) ETHER
  • DI(2,2,2-TRIFLUOROETHYL)ETHER
  • FLUROTHYL
  • 2-trifluoroethyl) ether
  • Bis(2,2,2-trifluoroethyl) Ether &gt
  • 2,2,2-Trifluorodiethyl ether
  • SKL232
  • inhibit,Fluorothyl,Inhibitor
  • 333-36-8
  • CF3CH22O
  • Building Blocks
  • Oxygen Compounds
  • Organic Building Blocks
  • Ethers
  • IMITREX