BIS(2,2,2-TRIFLUOROETHYL) ETHER Property

Melting point:

25°C

Boiling point:

62-63 °C (lit.)

Density 

1.404 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.300(lit.)

Flash point:

35 °F

storage temp. 

Flammables area

solubility 

DMSO : ≥ 125 mg/mL (686.59 mM)

form 

clear liquid

Specific Gravity

1.41

color 

Colorless to Almost colorless

Merck 

14,4201

BRN 

1811927

CAS DataBase Reference

333-36-8(CAS DataBase Reference)

EPA Substance Registry System

HFE-356mff2 (333-36-8)

Safety

Hazard Codes 

F,Xi,T

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36

RIDADR 

UN 3271 3/PG 2

WGK Germany 

3

RTECS 

KN3675000

Hazard Note 

Flammable/Toxic/Convulsant

HazardClass 

3.1

PackingGroup 

II

HS Code 

29091990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

BIS(2,2,2-TRIFLUOROETHYL) ETHER Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Originator

Indoklon ,Ohio Medical, US ,1964

Uses

Bis(2,2,2-trifluoroethyl) ether was used to diminish self-discharge of Li-S cells having both low- and high-sulfur-loading sulfur cathodes.

Uses

Bis(2,2,2-trifluoroethyl) Ether is Prophylactic and/or therapeutic agent for Alzheimer''s disease.

Uses

5HT agonist

Definition

ChEBI: Flurotyl is an ether.

Manufacturing Process

23 parts of sodium metal were placed in 300 parts of dry dioxane in a reactor equipped with an agitator and reflux condenser. The dioxane was heated to reflux while stirring.150 parts of 2,2,2-trifluoroethanol were added very slowly in the period of about 1 hour, or until the sodium was all reacted, to form sodium 2,2,2-trifluoroethylate. 250 parts of 2,2,2-trifluoroethyl ptoluenesulfonate prepared by reacting 2,2,2-trifluoroethanol with p Flurothyl toluenesulfonyl chloride were placed in another reactor and heated to about 160° to 185°C. The solution of sodium 2,2,2-trifluoroethylate in dioxane was added very slowly over a period of about 1? hours. Bis(2,2,2-trifluoroethyl) ether formed continuously and distilled from the reactor with the dioxane into a cooled receiving vessel. The condensed effluent from the reactor was fractionally distilled, yielding 46.5 parts of products boiling at 55° to 73°C.
The crude product was washed successively with concentrated HCl, 62% H2SO4,concentrated H2SO4 and 5% NaOH solution. It was dehydrated over a drying agent and then refractionated in a still. 20 parts of bis(2,2,2trifluoroethyl) ether were recovered (BP 62.5° to 63.5°C).

brand name

Indoklon (Ohmeda).

Therapeutic Function

Central stimulant, Convulsant