CARNOSOL
Description- Product Name
- CARNOSOL
- CAS No.
- 5957-80-2
- Chemical Name
- CARNOSOL
- Synonyms
- carnol;CARNOSOL;D-α-Alanine;Carnosol-RM;CARNOSOL(RG);CARNOSOL USP/EP/BP;Carnosol, 10 mM in DMSO;Carnosol(P)(Request Quote);Carnosol, froM RoseMarinus officinalis;Carnosol, 98%, from Rosemarinus officinalis
- CBNumber
- CB8736565
- Molecular Formula
- C20H26O4
- Formula Weight
- 330.42
- MOL File
- 5957-80-2.mol
CARNOSOL Property
- Melting point:
- 240～242℃
- Boiling point:
- 524.8±50.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:66.0(Max Conc. mg/mL);199.74(Max Conc. mM)
- form
- Solid
- pka
- 8.91±0.40(Predicted)
- color
- White
- biological source
- Rosemarinus officinalis L. leaves
- InChI
- InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
- InChIKey
- XUSYGBPHQBWGAD-PJSUUKDQSA-N
- SMILES
- C1(C)(C)[C@@]2([H])[C@]3(C(=O)O[C@@]([H])(C2)C2=C3C(O)=C(O)C(C(C)C)=C2)CCC1
- LogP
- 2.832 (est)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29322090
- Hazardous Substances Data
- 5957-80-2(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- PHL80150
- Product name
- Carnosol
- Purity
- phyproof<SUP>®</SUP> Reference Substance
- Packaging
- 10 mg
- Price
- $489
- Updated
- 2025/07/31
- Product number
- C9617
- Product name
- Carnosol
- Packaging
- 5mg
- Price
- $391
- Updated
- 2025/07/31
- Product number
- 49702
- Product name
- Carnosol
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $770
- Updated
- 2025/07/31
- Product number
- 89800
- Product name
- Carnosol
- Purity
- ≥96%
- Packaging
- 1mg
- Price
- $45
- Updated
- 2024/03/01
- Product number
- 89800
- Product name
- Carnosol
- Purity
- ≥96%
- Packaging
- 5mg
- Price
- $198
- Updated
- 2024/03/01
CARNOSOL Chemical Properties,Usage,Production
Description
Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.
Description
Carnosol is a phenol that has been found in rosemary (R. officinalis) and has diverse biological activities. It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 μM. Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays. It inhibits 5-lipoxygenase (5-LO; IC50 = 0.1 μM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC50 = 7 μM). In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis.
Chemical Properties
White powder
Uses
Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.
Definition
ChEBI: Carnosol is a diterpenoid.
Cytotoxicity
IC50 (μg/mL): 65 (HL-60), 58 (K562), 50(Hep G2), 48 (MCF-7), 53 (MOLT-4)(Farimani et al. 2012)
IC50 (μg/mL): 61.46 (AGS) (Areche et al.2009)
IC50 (μg/mL): 2 (P388) (Aoyagi et al.2006)
IC50 (μg/mL): 1.19 (A2780), 3.30(SW1573), 8.59 (WiDr), 7.93 (T-47D),1.29 (HBL-100) (Guerrero et al. 2006).
References
[1] MARION MAN-YING CHAN Hsing I H Chi Tang Ho. Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production[J]. Cancer letters, 1995, 96 1: Pages 23-29. DOI: 10.1016/0304-3835(95)03913-h
[2] O I ARUOMA. Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid.[J]. Xenobiotica, 1992, 22 2: 257-268. DOI: 10.3109/00498259209046624
[3] DANIEL POECKEL . Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes[J]. Biochemical pharmacology, 2008, 76 1: Pages 91-97. DOI: 10.1016/j.bcp.2008.04.013
[4] KEITH SINGLETARY Matthew W Christopher MacDonald. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation[J]. Cancer letters, 1996, 104 1: Pages 43-48. DOI: 10.1016/0304-3835(96)04227-9
CARNOSOL Preparation Products And Raw materials
Raw materials
Preparation Products
CARNOSOL Suppliers
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View Lastest Price from CARNOSOL manufacturers
- Product
- Carnosol 5957-80-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-15
- Product
- Carnosol 5957-80-2
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-04-07
- Product
- CARNOSOL 5957-80-2
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2018-08-20