CARNOSOL

Description

Product Name: CARNOSOL
CAS No.: 5957-80-2
Chemical Name: CARNOSOL
Synonyms: carnol;CARNOSOL;D-α-Alanine;Carnosol-RM;CARNOSOL(RG);CARNOSOL USP/EP/BP;Carnosol, 10 mM in DMSO;Carnosol(P)(Request Quote);Carnosol, froM RoseMarinus officinalis;Carnosol, 98%, from Rosemarinus officinalis
CBNumber: CB8736565
Molecular Formula: C20H26O4
Formula Weight: 330.42
MOL File: 5957-80-2.mol

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CARNOSOL Property

Melting point:: 240～242℃
Boiling point:: 524.8±50.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:66.0(Max Conc. mg/mL);199.74(Max Conc. mM)
form: Solid
pka: 8.91±0.40(Predicted)
color: White
biological source: Rosemarinus officinalis L. leaves
Major Application: food and beverages
InChI: InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
InChIKey: XUSYGBPHQBWGAD-PJSUUKDQSA-N
SMILES: C1(C)(C)[C@@]2([H])[C@]3(C(=O)O[C@@]([H])(C2)C2=C3C(O)=C(O)C(C(C)C)=C2)CCC1
LogP: 2.832 (est)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29322090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Skin Sens. 1
Hazardous Substances Data: 5957-80-2(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL80150
Product name: Carnosol
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 10 mg
Price: $489
Updated: 2025/07/31

Sigma-Aldrich

Product number: C9617
Product name: Carnosol
Packaging: 5mg
Price: $391
Updated: 2025/07/31

Sigma-Aldrich

Product number: 49702
Product name: Carnosol
Purity: analytical standard
Packaging: 10mg
Price: $770
Updated: 2025/07/31

Cayman Chemical

Product number: 89800
Product name: Carnosol
Purity: ≥96%
Packaging: 1mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 89800
Product name: Carnosol
Purity: ≥96%
Packaging: 5mg
Price: $198
Updated: 2024/03/01

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CARNOSOL Chemical Properties,Usage,Production

Description

Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.

Description

Carnosol is a phenol that has been found in rosemary (R. officinalis) and has diverse biological activities. It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 μM. Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays. It inhibits 5-lipoxygenase (5-LO; IC₅₀ = 0.1 μM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC₅₀ = 7 μM). In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis.

Chemical Properties

White powder

Uses

Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.

Definition

ChEBI: Carnosol is a diterpenoid.

Cytotoxicity

IC₅₀ (μg/mL): 65 (HL-60), 58 (K562), 50(Hep G2), 48 (MCF-7), 53 (MOLT-4)(Farimani et al. 2012)
IC₅₀ (μg/mL): 61.46 (AGS) (Areche et al.2009)
IC₅₀ (μg/mL): 2 (P388) (Aoyagi et al.2006)
IC₅₀ (μg/mL): 1.19 (A2780), 3.30(SW1573), 8.59 (WiDr), 7.93 (T-47D),1.29 (HBL-100) (Guerrero et al. 2006).

Synthesis

Take 2000g of dried rosemary branches and leaves, add 14L of petroleum ether, reflux extraction for 3 times, 3 hours each time, merge the 3 extracts, concentrate and recover the petroleum ether, get the extract; dissolve the extract with 40% ethanol, filter to remove insoluble matter, get 1000ml of mother liquor as adsorbent, adsorb the adsorbent with 500ml of D101 large pore adsorbent resin, adsorb and then elute the eluent with 1000ml of purified water, and then elute with 1500ml of 90% ethanol. Elution, and then eluted with 1500 ml of 90% ethanol solution, the eluent is divided into 6 sections, combined with the middle 4; combined eluent concentrated to 100 ml under reduced pressure, add 200 ml of water, stir to precipitate, and leave for 3 hours; centrifuged to get the precipitate containing sage bitter endolipids; precipitate dissolved with 200 ml of ethyl acetate, to which 200 ml of petroleum ether was added, stirring, precipitate precipitate; filtered to get the Sage bitter endolipid crude product, the crude product with 800 ml of anhydrous ethanol crystallization, to get the sage bitter endolipid crystals; filtration, drying, to get the crystals 13.6 g, HPLC detection of sage bitter endolipid content of 96.1%.

References

[1] MARION MAN-YING CHAN Hsing I H Chi Tang Ho. Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production[J]. Cancer letters, 1995, 96 1: Pages 23-29. DOI: 10.1016/0304-3835(95)03913-h
[2] O I ARUOMA. Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid.[J]. Xenobiotica, 1992, 22 2: 257-268. DOI: 10.3109/00498259209046624
[3] DANIEL POECKEL . Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes[J]. Biochemical pharmacology, 2008, 76 1: Pages 91-97. DOI: 10.1016/j.bcp.2008.04.013
[4] KEITH SINGLETARY Matthew W Christopher MacDonald. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation[J]. Cancer letters, 1996, 104 1: Pages 43-48. DOI: 10.1016/0304-3835(96)04227-9

CARNOSOL Preparation Products And Raw materials

Raw materials

Preparation Products

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CARNOSOL Suppliers

China 217 India 3 Switzerland 2 United Kingdom 6 United States 25 Global 253

Chengdu Biopurify Ltd.

Tel: 28-82633860 18982077548
Email: cwb1@biopurify.cn
Country: China
ProdList: 3851
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4765
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5645
Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

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View Lastest Price from CARNOSOL manufacturers

BINBO BIOLOGICAL CO.,LTD

Product: Carnosol 5957-80-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2024-04-15

Shanghai Standard Technology Co., Ltd.

Product: Carnosol 5957-80-2
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-04-07

Career Henan Chemical Co

Product: CARNOSOL 5957-80-2
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1 ton
Release date: 2018-08-20

5957-80-2, CARNOSOLRelated Search:

CARNOSOL Carnosic acid 1-PHENYL-1-CYCLOHEXANECARBOXYLIC ACID cyclomenol 1-(4-Methylphenyl)-1-cyclohexanecarboxylic acid 2 [PARA ISOPROPYL PHENYL] PROPIONALDEHYDE 2-CYCLOHEXYL-5-METHYLPHENOL ethyl 2-(4-ethylphenyl)acetate pisiferic acid CARNOSOL(NOW AVAILABLE IN GRAM SIZES)(P),CARNOSOL(P) Carnosol, Rosmarinus officinalis tetrahydro-3-pentyl-2H-pyran-2-one 4-(1-METHYLETHYL)-BENZENEACETIC ACID METHYL ESTER ethyl 4-isopropylphenylacetate (1-phenylcyclohexane)methanol DEHYDROABIETINE 1-Phenylcyclohexane-1-carbaldehyde 3-ISOPROPYL-6-METHYLCATECHOL

1,3,4,9,10,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE

1,3,4,9,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE

1,2,3,4,4A,9,10,10AS-OCTAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISOPROPYL-9S, 4AR (EPOXYMETHANO)PHENANTHREN-12-ONE

CARNOSOL(RG)

CARNOSOL

Carnosol, froM RoseMarinus officinalis

Carnosol, 98%, from Rosemarinus officinalis

2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10aS)-

CARNOSOL USP/EP/BP

(4aR,9S,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-2,3,4,9,10,10a-hexahydro-1H-9,4a-(epoxymethano)phenanthren-12-one

D-α-Alanine

carnol

(5b,7a)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one

Carnosol(P)(Request Quote)

Carnosol-RM

Carnosol, 10 mM in DMSO

5957-80-2

chemical reagent

pharmaceutical intermediate

Miscellaneous Natural Products

Antioxidant

Biochemicals Found in Plants

Nutrition Research

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract