CARNOSOL

ChemicalBook > CAS DataBase List > CARNOSOL

Description

Product Name: CARNOSOL
CAS No.: 5957-80-2
Chemical Name: CARNOSOL
Synonyms: carnol;CARNOSOL;D-α-Alanine;Carnosol-RM;CARNOSOL(RG);CARNOSOL USP/EP/BP;Carnosol(P)(Request Quote);Carnosol, froM RoseMarinus officinalis;Carnosol, 98%, from Rosemarinus officinalis;(5b,7a)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one
CBNumber: CB8736565
Molecular Formula: C20H26O4
Formula Weight: 330.42
MOL File: 5957-80-2.mol

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CARNOSOL Property

Melting point:: 240～242℃
Boiling point:: 524.8±50.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:66.0(Max Conc. mg/mL);199.74(Max Conc. mM)
form: Solid
pka: 8.91±0.40(Predicted)
color: White
LogP: 2.832 (est)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29322090
Hazardous Substances Data: 5957-80-2(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C9617
Product name: Carnosol
Packaging: 5mg
Price: $380
Updated: 2024/03/01

Sigma-Aldrich

Product number: 49702
Product name: Carnosol
Purity: analytical standard
Packaging: 10mg
Price: $747
Updated: 2024/03/01

Cayman Chemical

Product number: 89800
Product name: Carnosol
Purity: ≥96%
Packaging: 1mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 89800
Product name: Carnosol
Purity: ≥96%
Packaging: 5mg
Price: $198
Updated: 2024/03/01

Cayman Chemical

Product number: 89800
Product name: Carnosol
Purity: ≥96%
Packaging: 10mg
Price: $351
Updated: 2024/03/01

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CARNOSOL Chemical Properties,Usage,Production

Description

Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.

Description

Carnosol is a phenol that has been found in rosemary (R. officinalis) and has diverse biological activities. It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 μM. Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays. It inhibits 5-lipoxygenase (5-LO; IC₅₀ = 0.1 μM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC₅₀ = 7 μM). In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis.

Chemical Properties

White powder

Uses

Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.

Definition

ChEBI: Carnosol is a diterpenoid.

Cytotoxicity

IC₅₀ (μg/mL): 65 (HL-60), 58 (K562), 50(Hep G2), 48 (MCF-7), 53 (MOLT-4)(Farimani et al. 2012)
IC₅₀ (μg/mL): 61.46 (AGS) (Areche et al.2009)
IC₅₀ (μg/mL): 2 (P388) (Aoyagi et al.2006)
IC₅₀ (μg/mL): 1.19 (A2780), 3.30(SW1573), 8.59 (WiDr), 7.93 (T-47D),1.29 (HBL-100) (Guerrero et al. 2006).

CARNOSOL Preparation Products And Raw materials

Raw materials

Preparation Products

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CARNOSOL Suppliers

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View Lastest Price from CARNOSOL manufacturers

BINBO BIOLOGICAL CO.,LTD

Product: Carnosol 5957-80-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2024-04-15

Shanghai Standard Technology Co., Ltd.

Product: Carnosol 5957-80-2
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-04-07

Career Henan Chemical Co

Product: CARNOSOL 5957-80-2
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1 ton
Release date: 2018-08-20

5957-80-2, CARNOSOLRelated Search:

CARNOSOL Carnosic acid 1-PHENYL-1-CYCLOHEXANECARBOXYLIC ACID cyclomenol 1-(4-Methylphenyl)-1-cyclohexanecarboxylic acid 2 [PARA ISOPROPYL PHENYL] PROPIONALDEHYDE 2-CYCLOHEXYL-5-METHYLPHENOL ethyl 2-(4-ethylphenyl)acetate pisiferic acid CARNOSOL(NOW AVAILABLE IN GRAM SIZES)(P),CARNOSOL(P) Carnosol, Rosmarinus officinalis tetrahydro-3-pentyl-2H-pyran-2-one 4-(1-METHYLETHYL)-BENZENEACETIC ACID METHYL ESTER ethyl 4-isopropylphenylacetate (1-phenylcyclohexane)methanol DEHYDROABIETINE 1-Phenylcyclohexane-1-carbaldehyde 3-ISOPROPYL-6-METHYLCATECHOL

1,3,4,9,10,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE

1,3,4,9,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE

1,2,3,4,4A,9,10,10AS-OCTAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISOPROPYL-9S, 4AR (EPOXYMETHANO)PHENANTHREN-12-ONE

CARNOSOL(RG)

CARNOSOL

Carnosol, froM RoseMarinus officinalis

Carnosol, 98%, from Rosemarinus officinalis

2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10aS)-

CARNOSOL USP/EP/BP

(4aR,9S,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-2,3,4,9,10,10a-hexahydro-1H-9,4a-(epoxymethano)phenanthren-12-one

D-α-Alanine

carnol

(5b,7a)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one

Carnosol(P)(Request Quote)

Carnosol-RM

5957-80-2

chemical reagent

pharmaceutical intermediate

Miscellaneous Natural Products

Antioxidant

Biochemicals Found in Plants

Nutrition Research

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract