Description
ChemicalBook > CAS DataBase List > CARNOSOL

CARNOSOL

Description
Product Name
CARNOSOL
CAS No.
5957-80-2
Chemical Name
CARNOSOL
Synonyms
carnol;CARNOSOL;D-α-Alanine;Carnosol-RM;CARNOSOL(RG);CARNOSOL USP/EP/BP;Carnosol(P)(Request Quote);Carnosol, froM RoseMarinus officinalis;Carnosol, 98%, from Rosemarinus officinalis;(5b,7a)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one
CBNumber
CB8736565
Molecular Formula
C20H26O4
Formula Weight
330.42
MOL File
5957-80-2.mol
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CARNOSOL Property

Melting point:
240～242℃
Boiling point:
524.8±50.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO:66.0(Max Conc. mg/mL);199.74(Max Conc. mM)
form 
Solid
pka
8.91±0.40(Predicted)
color 
White
LogP
2.832 (est)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29322090
Hazardous Substances Data
5957-80-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C9617
Product name
Carnosol
Packaging
5mg
Price
$380
Updated
2024/03/01
Sigma-Aldrich
Product number
49702
Product name
Carnosol
Purity
analytical standard
Packaging
10mg
Price
$747
Updated
2024/03/01
Cayman Chemical
Product number
89800
Product name
Carnosol
Purity
≥96%
Packaging
1mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
89800
Product name
Carnosol
Purity
≥96%
Packaging
5mg
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
89800
Product name
Carnosol
Purity
≥96%
Packaging
10mg
Price
$351
Updated
2024/03/01
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CARNOSOL Chemical Properties,Usage,Production

Description

Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.

Description

Carnosol is a phenol that has been found in rosemary (R. officinalis) and has diverse biological activities. It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 μM. Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays. It inhibits 5-lipoxygenase (5-LO; IC50 = 0.1 μM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC50 = 7 μM). In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis.

Chemical Properties

White powder

Uses

Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.

Definition

ChEBI: Carnosol is a diterpenoid.

Cytotoxicity

IC50 (μg/mL): 65 (HL-60), 58 (K562), 50(Hep G2), 48 (MCF-7), 53 (MOLT-4)(Farimani et al. 2012)
IC50 (μg/mL): 61.46 (AGS) (Areche et al.2009)
IC50 (μg/mL): 2 (P388) (Aoyagi et al.2006)
IC50 (μg/mL): 1.19 (A2780), 3.30(SW1573), 8.59 (WiDr), 7.93 (T-47D),1.29 (HBL-100) (Guerrero et al. 2006).

CARNOSOL Preparation Products And Raw materials

Raw materials

Preparation Products

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CARNOSOL Suppliers

China 171 India 2 Switzerland 2 United Kingdom 6 United States 24 Global 205
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
Alexis Corporation
Tel
--
Fax
--
Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
74
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View Lastest Price from CARNOSOL manufacturers

BINBO BIOLOGICAL CO.,LTD
Product
Carnosol 5957-80-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
1000 kg
Release date
2024-04-15
Shanghai Standard Technology Co., Ltd.
Product
Carnosol 5957-80-2
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-04-07
Career Henan Chemical Co
Product
CARNOSOL 5957-80-2
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1 ton
Release date
2018-08-20

5957-80-2, CARNOSOLRelated Search:

CARNOSOL Carnosic acid 1-PHENYL-1-CYCLOHEXANECARBOXYLIC ACID cyclomenol 1-(4-Methylphenyl)-1-cyclohexanecarboxylic acid 2 [PARA ISOPROPYL PHENYL] PROPIONALDEHYDE 2-CYCLOHEXYL-5-METHYLPHENOL ethyl 2-(4-ethylphenyl)acetate pisiferic acid CARNOSOL(NOW AVAILABLE IN GRAM SIZES)(P),CARNOSOL(P) Carnosol, Rosmarinus officinalis tetrahydro-3-pentyl-2H-pyran-2-one 4-(1-METHYLETHYL)-BENZENEACETIC ACID METHYL ESTER ethyl 4-isopropylphenylacetate (1-phenylcyclohexane)methanol DEHYDROABIETINE 1-Phenylcyclohexane-1-carbaldehyde 3-ISOPROPYL-6-METHYLCATECHOL

  • 1,3,4,9,10,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE
  • 1,3,4,9,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE
  • 1,2,3,4,4A,9,10,10AS-OCTAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISOPROPYL-9S, 4AR (EPOXYMETHANO)PHENANTHREN-12-ONE
  • CARNOSOL(RG)
  • CARNOSOL
  • Carnosol, froM RoseMarinus officinalis
  • Carnosol, 98%, from Rosemarinus officinalis
  • 2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10aS)-
  • CARNOSOL USP/EP/BP
  • (4aR,9S,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-2,3,4,9,10,10a-hexahydro-1H-9,4a-(epoxymethano)phenanthren-12-one
  • D-α-Alanine
  • carnol
  • (5b,7a)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one
  • Carnosol(P)(Request Quote)
  • Carnosol-RM
  • 5957-80-2
  • chemical reagent
  • pharmaceutical intermediate
  • Miscellaneous Natural Products
  • Antioxidant
  • Biochemicals Found in Plants
  • Nutrition Research
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract