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Apramycin sulfate

Product Name
Apramycin sulfate
CAS No.
65710-07-8
Chemical Name
Apramycin sulfate
Synonyms
Ai3-29795;NEBRAMYCIN II;ApraMycin sulf;Nebramycin 11;Abrams sulfate;Unii-8uyl6naz3q;Einecs 265-890-7;AMPRAMYCINSULFATE;APRAMYCIN SULPHATE;Apramycin sulfater
CBNumber
CB8741912
Molecular Formula
C21H43N5O15S
Formula Weight
637.66
MOL File
65710-07-8.mol
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Apramycin sulfate Property

Melting point:
>168°C (dec.)
Boiling point:
823℃
Density 
1.56
Flash point:
451.6°(845°F)
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: soluble25mg/mL
form 
powder
color 
white to light yellow
Water Solubility 
Soluble in water.
JECFA Number
75
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Safety

Hazard Codes 
T,Xn
Risk Statements 
61-35-36/37/38-20/21/22-36/38
Safety Statements 
53-26-36/37/39-45-36
WGK Germany 
3
F 
10
HS Code 
29419000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A2024
Product name
Apramycin sulfate salt
Purity
≥95% (TLC)
Packaging
1g
Price
$75.1
Updated
2025/07/31
Sigma-Aldrich
Product number
A2024
Product name
Apramycin sulfate salt
Purity
≥95% (TLC)
Packaging
5g
Price
$259
Updated
2025/07/31
TCI Chemical
Product number
A3395
Product name
Apramycin Sulfate
Packaging
5G
Price
$102
Updated
2025/07/31
TCI Chemical
Product number
A3395
Product name
Apramycin Sulfate
Packaging
25G
Price
$357
Updated
2025/07/31
Cayman Chemical
Product number
19688
Product name
Apramycin (sulfate)
Purity
≥550 u/mg
Packaging
500mg
Price
$26
Updated
2021/12/16
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Apramycin sulfate Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

antibacterial; LD50(iv) 280mg/kg(mouse)

Uses

Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis.

Uses

Apramycin sulfate is a broad spectrum aminocyclitol antibiotic and component of the Nebramycin complex, produced by a strain of Streptomyces tenebrarius. Antibacterial.

Definition

ChEBI: Apramycin sulfate is a glycoside and an amino cyclitol.

in vivo

Apramycin (200 mg/kg/d, s.c., 9 d) sulfate demonstrates significant in vivo efficacy in lungs of M. tuberculosis low-dose aerosol infection model IFN-γ knockout mice[2].
Apramycin (16, 32, 80 mg/kg, s.c., 24 h) sulfate dose-dependently reduces bacterial burden in the kidneys between 2-5 log10 and in blood between 2-3 log10 for neutropenic model of Staphylococcus aureus septicemia mice[2].
Apramycin (50 mg/kg/d, s.c., 21 d) sulfate induces nephrotoxicity scores comparable to those induced by Gentamicin (10 mg/kg/d)[3].

Animal Model:M. tuberculosis low-dose aerosol infection model of IFN-γ knockout mice [2]
Dosage:200 mg/kg/d
Administration:Subcutaneousinjection (s.c.) for 9 d
Result:Showed a 2.4-log10 CFU reduction and better antituberculous activity compared to Amikacin (1.8-log10 reduction).

IC 50

Aminoglycoside

Apramycin sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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Apramycin sulfate Suppliers

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Pure Chemistry Scientific Inc.
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View Lastest Price from Apramycin sulfate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Apramycin sulfate 65710-07-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Shandong Xuhuang New material CoLTD
Product
Apramycin Sulfate 65710-07-8
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200
Release date
2025-02-25
Hebei Yanxi Chemical Co., Ltd.
Product
Apramycin sulfate 65710-07-8
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-22

65710-07-8, Apramycin sulfateRelated Search:

Gentamicin sulfate Magnesium sulfate heptahydrate Ammonium sulfate Sodium sulfate APRAMYCIN Vanadyl sulfate Dimethyl sulfate Barium sulfate Kanamycin sulfate Zinc sulfate heptahydrate MICRONOMICIN SULFATE Neomycin sulfate Aluminum sulfate Spectinomycin sulfate tetrahydrate sulfate Apramycin sulfate Apramycin sulfate 3'-Hydroxy Apramycin

  • APRAMYCIN SULPHATE
  • APRAMYCIN SULFATE SALT
  • 5-AMINO-2-[[9-AMINO-8-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXOXY)-5-HYDROXY-4-METHYLAMINO-2,7-DIOXABICYCLO[4.4.0]DEC-3-YL]OXY]-6-(HYDROXYMETHYL)OXANE-3,4-DIOL
  • NEBRAMYCIN II SULFATE
  • ApraMycin sulf
  • Apramycin sulfate solution,1000ppm
  • D-Streptamine, O-4-amino-4-deoxy-α-D-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (1:)
  • Apramycin sulfate Solution Solution, 100ppm
  • Apramycin sulfate salt, >500U/mg
  • NEBRAMYCIN II
  • NEBRAMYCIN 11 SULPHATE
  • AMPRAMYCINSULFATE
  • Nebramycin 11
  • 4-O-((8R)-2-Amino-8-O-(4-amino-4-deoxy-alpha-D-glucopyranosyl)-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octodialdo-1,5:8,4-dipyranos-1-yl)-2-deoxy-D-streptamine sulfate C21H41N5O11 .XH2SO4
  • Apramycin·sulfuric acid
  • 4-O-[(8R)-8-O-(4-Amino-4-deoxy-α-D-glucopyranosyl)-2-amino-7-methylamino-2,3,7-trideoxy-α-D-glycero-D-allo-octodialdo-1,5:8,4-dipyranosyl]-2-deoxy-D-streptamine/sulfuric acid,(1:x)
  • Ai3-29795
  • Apramycin, sulfate (2:5)
  • D-Streptamine, o-4-amino-4-deoxy-alpha-D-glucopyranosyl-(1-8)-o-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octadialdo-1,5:8,4-dipyranosyl-(1-4)-2-deoxy-, sulfate (salt)
  • Einecs 265-890-7
  • Unii-8uyl6naz3q
  • Apramycin sulfate salt,Nebramycin II
  • D-Streptamine, O-4-amino-4-deoxy-.alpha.-D-glucopyranosyl-(1?8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-.alpha.-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1?4)-2-deoxy-, sulfate (salt)
  • O-4-AMino-4-deoxy-α-D-glucopyranosyl-(18)-O-(8R)-2-aMino-2,3,7-trideoxy-7-(MethylaMino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(14)-2-deoxy-D-streptaMineSulfate
  • AMpraMycin sulfate API
  • Apramycin sulfate solution in Methanol, 100μg/mL
  • Apramycin sulfater
  • (2R,3R,4S,5S,6S)-5-Amino-2-(((2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol xsulfate
  • Apramycin Sulfate (Nebramycin II)
  • Abrams sulfate
  • Apramycinsulfatesal
  • 3'-Hydroxy Apramycin X-Sulfate
  • Nebramycin II|||Ai3-29795
  • C10293000 Apramycin sulfate
  • Apramycin sulfate in Water
  • Apramycin sulfate, 10 mM in DMSO
  • Apramycinsulfate(1:x)
  • 65710-07-8
  • C21H41N5O11xH2O4S
  • C21H41N5O11H2O4S
  • C21H41N5O11xH2SO4
  • C21H41N5O11x25H2SO4
  • C21H41N5O11x2x5H2SO4
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