(4-BROMO-3-FLUOROPHENYL)METHANOL
- Product Name
- (4-BROMO-3-FLUOROPHENYL)METHANOL
- CAS No.
- 222978-01-0
- Chemical Name
- (4-BROMO-3-FLUOROPHENYL)METHANOL
- Synonyms
- 3-Fluoro-4-Bromobenzyl alcohol;4-Bromo-3-fluorobenzenemethanol;(4-BROMO-3-FLUOROPHENYL)METHANOL;4-Bromo-3-fluorobenzylalcohol,96%;BenzeneMethanol, 4-broMo-3-fluoro-;(4-BROMO-3-FLUOROPHENYL)METHANOL ISO 9001：2015 REACH
- CBNumber
- CB8750392
- Molecular Formula
- C7H6BrFO
- Formula Weight
- 205.02
- MOL File
- 222978-01-0.mol
(4-BROMO-3-FLUOROPHENYL)METHANOL Property
- Melting point:
- 44.0 to 48.0 °C
- Boiling point:
- 260℃
- Density
- 1.658
- Flash point:
- 111℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 13.70±0.10(Predicted)
- color
- White to Almost white
Safety
- HS Code
- 2906290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B4956
- Product name
- 4-Bromo-3-fluorobenzyl Alcohol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $78
- Updated
- 2025/07/31
- Product number
- B693038
- Product name
- (4-Bromo-3-fluorophenyl)methanol
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B693038
- Product name
- (4-Bromo-3-fluorophenyl)methanol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B693038
- Product name
- (4-Bromo-3-fluorophenyl)methanol
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B693038
- Product name
- (4-Bromo-3-fluorophenyl)methanol
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
(4-BROMO-3-FLUOROPHENYL)METHANOL Chemical Properties,Usage,Production
Uses
(4-Bromo-3-fluorophenyl)methanol is used to prepare triazolopyridyl compounds, which can be used as a prodrug of RIPK1 inhibitors.
Synthesis
153556-42-4
222978-01-0
GENERAL METHODS: Borane-tetrahydrofuran complex (BH3-THF, 89 mL, 89.49 mmol) was slowly added dropwise to a stirred solution of 3-fluoro-4-bromobenzoic acid (9.8 g, 44.75 mmol) in tetrahydrofuran (THF, 200 mL) at 25 °C. The dropwise addition was controlled to be completed in 10 min, and the reaction was carried out under nitrogen protection. The reaction mixture was stirred continuously at room temperature for 2 days. Upon completion of the reaction, the reaction was carefully quenched with 2 M sodium carbonate solution (Na2CO3, 200 mL) and subsequently extracted with ether (Et2O, 2 x 500 mL). The organic phases were combined, washed with saturated brine (400 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give a pale yellow oil. The crude product was purified by fast silica gel column chromatography, the eluent was a mixture of heptane and ethyl acetate (EtOAc) with a gradient elution ratio of 0 to 70% ethyl acetate. The purified fraction was collected and concentrated to dryness under reduced pressure to give 4-bromo-3-fluorobenzyl alcohol (8.65 g, 94% yield) as a white solid.
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 21, p. 9096 - 9104
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 14, p. 2973 - 2984
[3] Synlett, 2014, vol. 25, # 1, p. 123 - 127
[4] European Journal of Medicinal Chemistry, 2018, vol. 150, p. 506 - 524
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 10, p. 1257 - 1260
(4-BROMO-3-FLUOROPHENYL)METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (4-BROMO-3-FLUOROPHENYL)METHANOL manufacturers
- Product
- (4-Bromo-3-fluorophenyl)methanol 222978-01-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.4%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- (4-BROMO-3-FLUOROPHENYL)METHANOL 222978-01-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20