ChemicalBook > CAS DataBase List > Potassium canrenoate
Potassium canrenoate
- Product Name
- Potassium canrenoate
- CAS No.
- 2181-04-6
- Chemical Name
- Potassium canrenoate
- Synonyms
- D01943;CB 8109;Kanrenol;MF 465 a;SC 14266;Venactone;Canrenoate;Soldactona;Soldactone;Soludactone
- CBNumber
- CB8774235
- Molecular Formula
- C11H15KO2
- Formula Weight
- 218.33
- MOL File
- 2181-04-6.mol
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Potassium canrenoate Property
- Melting point:
- 242-244°C (dec.)
- Density
- 1.345 g/cm3
- storage temp.
- Refrigerator
- solubility
- Methanol (Slightly)
- form
- powder
- color
- light yellow to tan
- CAS DataBase Reference
- 2181-04-6(CAS DataBase Reference)
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N-Bromosuccinimide Price
Alfa Aesar
- Product number
- J61394
- Product name
- Canrenoic acid potassium salt, 98+%
- Packaging
- 1g
- Price
- $52.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J61394
- Product name
- Canrenoic acid potassium salt, 98+%
- Packaging
- 5g
- Price
- $153.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J61394
- Product name
- Canrenoic acid potassium salt, 98+%
- Packaging
- 25g
- Price
- $580.65
- Updated
- 2024/03/01
TRC
- Product number
- C175625
- Product name
- CanrenoicAcidPotassiumSalt
- Packaging
- 50g
- Price
- $1210
- Updated
- 2021/12/16
TRC
- Product number
- C175625
- Product name
- CanrenoicAcidPotassiumSalt
- Packaging
- 5g
- Price
- $155
- Updated
- 2021/12/16
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Potassium canrenoate Chemical Properties,Usage,Production
Originator
Spiroctan,Boehringer Mannheim,Switz.,1968
Uses
Canrenoic acid is an aldosterone antagonist. Canrenoic acid is used as an diuretic.
Uses
anticholithogenic, antilipemic agent
Manufacturing Process
The lactone is prepared as follows: A solution of 5 parts of 17α-carboxyethyl- 17β-hydroxyandrost-4-en-3-one lactone and 5 parts of chloranil in 400 parts of xylene containing a trace of p-toluenesulfonic acid is heated at the boiling point of the solvent under reflux overnight. The solution is then cooled and filtered through approximately 200 parts of silica gel. The gel is successively washed with 5%, 10%, and 15% ethyl acetate-benzene solutions, and the washings comprising 15% ethyl acetate are thereupon purified by chromatography on a further quantity of silica gel, using benzene and ethyl acetate as developing solvents. From the 15% ethyl acetate eluate there is obtained pure 17α-carboxyethyl-17β-hydroxyandrost-4,6-dien-3-one lactone, melting at 148° to 151°C. The product solidifies above this melting point and melts again at 165°C.
brand name
Aldactone-diurapid;Aldadiene potassium;Kadiur;Lasiren;Luvion;Osirenol;Osyrol-lasix;Phanurane;Sincomen pro injectione;Speroctan-m;Spiroctan.
Therapeutic Function
Aldosterone antagonist, Diuretic
World Health Organization (WHO)
Potassium canrenoate, which has no intrinsic aldosterone antagonist activity, owes its therapeutic effect to the enzymatic interconversion in the body to canrenone. Evidence that long-term administration of high doses are tumorigenic in the rat has recently led to restriction of its use by some national regulatory authorities. See also WHO comments for canrenone and spironolactone.
Potassium canrenoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Potassium canrenoate manufacturers
Wuhan Senwayer Century Chemical Co.,Ltd
- Product
- Potassium canrenoate 2181-04-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99% min
- Supply Ability
- 20 tons
- Release date
- 2022-12-02
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