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2-Amino-6-chlorobenzotrifluoride

Product Name
2-Amino-6-chlorobenzotrifluoride
CAS No.
432-21-3
Chemical Name
2-Amino-6-chlorobenzotrifluoride
Synonyms
3-Chloro-2-(trifluoromethyl)aniline;2-AMINO-6-CHLOROBENZOTRIFLUORIDE;2-AMINO-6-CHLOROBENZOTRIFLUOROIDE;2-TRIFLUOROMETHYL-3-CHLOROANILINE;3-chloro-2-(trifluoromethyl)aniline 2;3-Chloro-2-trifluoromethyl-phenylamine;Benzenamine, 3-chloro-2-(trifluoromethyl)-;2-chloro 6-aminobenzotrifluoride (Or) Benzenamine,3-chloro-2-(trifluoromethyl)
CBNumber
CB8776097
Molecular Formula
C7H5ClF3N
Formula Weight
195.57
MOL File
432-21-3.mol
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2-Amino-6-chlorobenzotrifluoride Property

Boiling point:
55-60 °C
Density 
1.425±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
0.41±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
CAS DataBase Reference
432-21-3(CAS DataBase Reference)
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Safety

HS Code 
2921490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0060309
Product name
3-Chloro-2-(trifluoromethyl)aniline
Packaging
250mg
Price
$58
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA67615
Product name
2-Amino-6-chlorobenzotrifluoride
Packaging
1g
Price
$72.5
Updated
2021/12/16
ChemScene
Product number
CS-0060309
Product name
3-Chloro-2-(trifluoromethyl)aniline
Packaging
1g
Price
$113
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA67615
Product name
2-Amino-6-chlorobenzotrifluoride
Packaging
2g
Price
$116
Updated
2021/12/16
AK Scientific
Product number
V2171
Product name
2-Amino-6-chlorobenzotrifluoride
Packaging
1g
Price
$147
Updated
2021/12/16
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2-Amino-6-chlorobenzotrifluoride Chemical Properties,Usage,Production

Synthesis

133391-58-9

432-21-3

1-Chloro-3-nitro-2-trifluoromethylbenzene (221.27 g, 0.981 mol) was used as a raw material in a 5 L multi-necked flask equipped with a mechanical stirrer, thermocouple casing, condenser, nitrogen inlet line, and a dropping funnel with ethanol (denatured with 5% methanol and isopropanol, 3.46 L), water (0.87 L), zinc powder (384.71 g, 5.885 mol) and anhydrous calcium chloride (108.88 g, 0.981 mol). The mixture was heated to reflux and reacted overnight. The progress of the reaction was monitored by GC to confirm the complete disappearance of the feedstock (tR = 3.52 min) and the formation of the product (tR = 3.25 min). After completion of the reaction, the mixture was cooled to 30 °C and filtered through a diatomaceous earth pad (200 g). The solid was washed with ethanol (2 × 500 mL), the filtrate was combined and concentrated. Ethyl acetate (0.5 L) was added to the residue and the organic layer was separated and washed sequentially with water (2 × 500 mL) and brine. The aqueous layer was then back-extracted with ethyl acetate (2 × 0.5 L). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and the volatiles were evaporated to give 175.31 g (91% yield) of 3-chloro-2-trifluoromethylaniline (80.9% GC purity). The structure of the product was confirmed by 1H NMR and 19F NMR analyses, and 10-20% impurities and 0.5 equivalents of ethyl acetate were detected. The purity of the product met the requirements of the next reaction and no further purification was required.GC analysis conditions: DB5 column (30 m × 0.32 mm ID, 0.25 μm film thickness), temperature program 75-300 ℃, ramp rate 15 ℃/min, injector temperature 275 ℃, detector temperature 350 ℃. Mass spectrometry analysis (APCI): m/z 196.1 (M+1, calculated value 195.0).

References

[1] Patent: US2008/167319, 2008, A1. Location in patent: Page/Page column 4

2-Amino-6-chlorobenzotrifluoride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-6-chlorobenzotrifluoride Suppliers

China 82 Europe 2 Germany 1 India 2 United Kingdom 6 United States 11 Global 104
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from 2-Amino-6-chlorobenzotrifluoride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-6-chlorobenzotrifluoride 432-21-3
Price
US $0.00-0.00/KG
Min. Order
50mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-08
Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-6-chlorobenzotrifluoride 432-21-3
Price
US $0.00-0.00/KG
Min. Order
50mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-08
Hangzhou ICH Biofarm Co., Ltd
Product
2-Amino-6-chlorobenzotrifluoride 432-21-3
Price
US $0.00-0.00/g
Min. Order
1g
Purity
97%
Supply Ability
20000kg
Release date
2023-07-12

432-21-3, 2-Amino-6-chlorobenzotrifluorideRelated Search:

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  • 2-AMINO-6-CHLOROBENZOTRIFLUORIDE
  • 2-TRIFLUOROMETHYL-3-CHLOROANILINE
  • 2-AMINO-6-CHLOROBENZOTRIFLUOROIDE
  • 3-Chloro-2-trifluoromethyl-phenylamine
  • 2-chloro 6-aminobenzotrifluoride (Or) Benzenamine,3-chloro-2-(trifluoromethyl)
  • 3-chloro-2-(trifluoromethyl)aniline 2
  • 3-Chloro-2-(trifluoromethyl)aniline
  • Benzenamine, 3-chloro-2-(trifluoromethyl)-
  • 432-21-3