ChemicalBook > CAS DataBase List > Vorsetuzumab
Vorsetuzumab
- Product Name
- Vorsetuzumab
- CAS No.
- 1165740-62-4
- Chemical Name
- Vorsetuzumab
- Synonyms
- SGN-70;Vorsetuzumab;Vorsetuzumab (anti-CD70);Research Grade Vorsetuzumab;Research Grade Vorsetuzumab(DHE01902)
- CBNumber
- CB88080868
- Formula Weight
- 0
- MOL File
- Mol file
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Vorsetuzumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Vorsetuzumab Chemical Properties,Usage,Production
Uses
Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a human anti-CD70 antibody. Vorsetuzumab enhances macrophage-related phagocytosis of renal carcinoma cells, shows inhibitory efficacy against Burkitt’s lymphoma[1].
in vivo
Vorsetuzumab (10 mg/kg; i.p.; every other day; for 12 d) inhibits Burkitt’s lymphoma cell growth growth in SRG mice[1].
| Animal Model: | Burkitt’s lymphoma xenograft model in SRG mice[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; every other day; for 12 d |
| Result: | Effectively inhibited Burkitt’s lymphoma cell growth but was not outperform the combination of the KWAR23 antibody (10 mg/kg). |
References
[1] Ring NG, et al. Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10578-E10585. DOI:10.1073/pnas.1710877114
Vorsetuzumab Preparation Products And Raw materials
Raw materials
Preparation Products
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