Mirvetuximab
- Product Name
- Mirvetuximab
- CAS No.
- 1453084-36-0
- Chemical Name
- Mirvetuximab
- Synonyms
- M9346A;Mirvetuximab;Mirvetuximab (DHD10402);Mirvetuximab (anti-FOLR1);Research Grade Mirvetuximab;Research Grade Mirvetuximab(DHD10402)
- CBNumber
- CB88080969
- Formula Weight
- 0
- MOL File
- Mol file
Mirvetuximab Property
- form
- Liquid
- color
- Colorless to light yellow
Mirvetuximab Chemical Properties,Usage,Production
Uses
Mirvetuximab (M9346A) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research[1][2][3].
References
[1] Moore KN, et al. Safety and Activity of Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha-Targeting Antibody-Drug Conjugate, in Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer: A Phase I Expansion Study. J Clin Oncol. 2017 Apr 1;35(10):1112-1118. DOI:10.1200/JCO.2016.69.9538
[2] Loebrich S, et al. Development and Characterization of a Neutralizing Anti-idiotype Antibody Against Mirvetuximab for Analysis of Clinical Samples. AAPS J. 2017 Jul;19(4):1223-1234. DOI:10.1208/s12248-017-0098-0
[3] Ab O, et al. IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors. Mol Cancer Ther. 2015 Jul;14(7):1605-13. DOI:10.1158/1535-7163.MCT-14-1095
Mirvetuximab Preparation Products And Raw materials
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Preparation Products
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