Tilvestamab

Product Name: Tilvestamab
CAS No.: 2226775-26-2
Chemical Name: Tilvestamab
Synonyms: Tilvestamab;Tilvestamab (anti-AXL);Research Grade Tilvestamab;Anti-Human Axl (Tilvestamab);Research Grade Tilvestamab(DHD89502)
CBNumber: CB88081193
Formula Weight: 0
MOL File: Mol file

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Tilvestamab Property

storage temp.: Store at -20°C
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Tilvestamab Chemical Properties,Usage,Production

Uses

Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits Gas6-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas[1].

in vivo

Tilvestamab (30 mg/kg; i.p.; twice a week) suppresses tumor growth by inhibiting AXL in orthotopic RCC model^[1].

Animal Model:	Female BALB/c athymic nude mice (8-week-old; orthotopic RCC model)^[1].
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection; twice a week
Result:	Significantly inhibited RCC growth down to about 1/3 of the volume.

IC 50

Axl

References

[1] Chen TJ, et al. AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model. Physiol Rep. 2021 Dec;9(23):e15140. DOI:10.14814/phy2.15140

Tilvestamab Preparation Products And Raw materials

Raw materials

Preparation Products

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Tilvestamab Suppliers

China 14 Global 14

Shanghai YuanYe Biotechnology Co., Ltd.

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Tilvestamab

Anti-Human Axl (Tilvestamab)

Research Grade Tilvestamab(DHD89502)

Research Grade Tilvestamab

Tilvestamab (anti-AXL)

2226775-26-2