Mal-PEG1-Val-Cit-PAB-PNP

Product Name: Mal-PEG1-Val-Cit-PAB-PNP
CAS No.: 2249935-92-8
Chemical Name: Mal-PEG1-Val-Cit-PAB-PNP
Synonyms: Mal-PEG1-Val-Cit-PAB-PNP;Mal-PEG1-Val-Cit-PAB-PNP ISO 9001：2015 REACH;L-Ornithinamide, N-[3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
CBNumber: CB88184517
Molecular Formula: C34H41N7O12
Formula Weight: 739.73
MOL File: 2249935-92-8.mol

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Mal-PEG1-Val-Cit-PAB-PNP Property

Boiling point:: 1039.5±65.0 °C(Predicted)
Density: 1.366±0.06 g/cm3(Predicted)
solubility: Soluble in DMSO, DMF
pka: 13.24±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24314
Product name: Mal-PEG1-Val-Cit-PAB-PNP
Purity: 96%
Packaging: 250mg
Price: $1800
Updated: 2021/12/16

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Mal-PEG1-Val-Cit-PAB-PNP Chemical Properties,Usage,Production

Description

Mal-PEG1-Val-Cit-PAB-PNP is a cleavable peptide linker. The Val-Cit was designed to be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups at pH 6.5 to 7.5. PNP is a good leaving group.

Uses

Mal-PEG1-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Mal-PEG1-Val-Cit-PAB-PNP Preparation Products And Raw materials

Raw materials

Preparation Products

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Mal-PEG1-Val-Cit-PAB-PNP Suppliers

China 14 United States 1 Global 15

Xi'an Confluore Biological Technology Co., Ltd.

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View Lastest Price from Mal-PEG1-Val-Cit-PAB-PNP manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Mal-PEG1-Val-Cit-PAB-PNP 2249935-92-8
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-03-29

2249935-92-8, Mal-PEG1-Val-Cit-PAB-PNPRelated Search:

2,5-Dioxopyrrolidin-1-yl 3-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)propanoate Mal-PEG1-acid Mal-PEG1-t-butyl ester Mal-amido-PEG1-acid 1-(2-HYDROXY-ETHYL)-PYRROLE-2,5-DIONE Mal-PEG1-NHS ester Mal-PEG1-PFP Mal-PEG1-Val-Cit-PABC-OH

Mal-PEG1-Val-Cit-PAB-PNP

Mal-PEG1-Val-Cit-PAB-PNP ISO 9001：2015 REACH

L-Ornithinamide, N-[3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-

2249935-92-8