3-Pyridineacetamide, N-cyclohexyl-α-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-, (αR)-
- Product Name
- 3-Pyridineacetamide, N-cyclohexyl-α-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-, (αR)-
- CAS No.
- 2455518-33-7
- Chemical Name
- 3-Pyridineacetamide, N-cyclohexyl-α-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-, (αR)-
- Synonyms
- X77;3-Pyridineacetamide, N-cyclohexyl-α-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-, (αR)-
- CBNumber
- CB88199883
- Molecular Formula
- C27H33N5O2
- Formula Weight
- 459.59
- MOL File
- 2455518-33-7.mol
3-Pyridineacetamide, N-cyclohexyl-α-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-, (αR)- Property
- Boiling point:
- 754.1±60.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 2mg/mL, clear
- form
- Solid
- pka
- 10.60±0.10(Predicted)
- color
- Off-white to light yellow
N-Bromosuccinimide Price
- Product number
- CS-0127760
- Product name
- X77
- Purity
- 99.71%
- Packaging
- 5mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CS-0127760
- Product name
- X77
- Purity
- 99.71%
- Packaging
- 10mg
- Price
- $800
- Updated
- 2021/12/16
- Product number
- CS-0127760
- Product name
- X77
- Purity
- 99.71%
- Packaging
- 25mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CS-0127760
- Product name
- X77
- Purity
- 99.71%
- Packaging
- 50mg
- Price
- $2550
- Updated
- 2021/12/16
- Product number
- CS-0127760
- Product name
- X77
- Purity
- 99.71%
- Packaging
- 100mg
- Price
- $3800
- Updated
- 2021/12/16
3-Pyridineacetamide, N-cyclohexyl-α-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-, (αR)- Chemical Properties,Usage,Production
Uses
X77 is a potent non-covalent inhibitor of the main protease of SARS-CoV-2 (SARS-CoV-2 Mpro)[1]. X77 binds to SARS-CoV-2 Mpro with a Kd value of 0.057 μM[2].
Biological Activity
X77 is considered as a reference standard in number of docking and x-ray studies. X77 is a high affinity non-covalent inhibitor of the SARS-CoV-2 main protease (SARS-CoV-2 Mpro). Its calculated dissociation constant (Kd) is 0.057 μM. X77 is an analog of ML188 a selective non-covalent SARS-CoV 3CLpro inhibitor (IC50 = 1.5 μM).
References
[1] Sohini Chakraborti, et al. Drug Repurposing Approach Targeted Against Main Protease of SARS-CoV-2 Exploiting ‘Neighbourhood Behaviour’ in 3D Protein Structural Space and 2D Chemical Space of Small Molecules.
[2] Alexander M Andrianov, et al. Computational discovery of small drug-like compounds as potential inhibitors of SARS-CoV-2 main protease. J Biomol Struct Dyn DOI:10.1080/07391102.2020.1792989
3-Pyridineacetamide, N-cyclohexyl-α-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-, (αR)- Preparation Products And Raw materials
Raw materials
Preparation Products
3-Pyridineacetamide, N-cyclohexyl-α-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-, (αR)- Suppliers
- Tel
- +17819995354
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- Country
- United States
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