ChemicalBook > CAS DataBase List > 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE

Product Name: 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE
CAS No.: 22536-66-9
Chemical Name: 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE
Synonyms: NSC 60802;2-CHLOROPYRIMIDINE-4-CARBOXAMIDE;2-chloro-4-Pyrimidinecarboxamide;4-Pyrimidinecarboxamide, 2-chloro-;2-Chloro-pyrimidine-4-carboxylic acid amide;4-(Aminocarbonyl)-2-chloropyrimidine, 4-Carbamoyl-2-chloropyrimidine
CBNumber: CB8829193
Molecular Formula: C5H4ClN3O
Formula Weight: 157.56
MOL File: 22536-66-9.mol

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2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
Appearance: White to off-white Solid
InChI: InChI=1S/C5H4ClN3O/c6-5-8-2-1-3(9-5)4(7)10/h1-2H,(H2,7,10)
InChIKey: UXXQEVFRPLIOHJ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(C(N)=O)=N1

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C597780
Product name: 2-Chloropyrimidine-4-carboxamide
Packaging: 500mg
Price: $220
Updated: 2021/12/16

Usbiological

Product number: 295672
Product name: 2-Chloropyrimidine-4-carboxamide
Packaging: 100mg
Price: $363
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NC57418
Product name: 2-Chloropyrimidine-4-carboxamide
Packaging: 2g
Price: $543.4
Updated: 2021/12/16

Matrix Scientific

Product number: 070084
Product name: 2-Chloropyrimidine-4-carboxamide
Purity: 96%
Packaging: 1g
Price: $605
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NC57418
Product name: 2-Chloropyrimidine-4-carboxamide
Packaging: 500mg
Price: $155
Updated: 2021/12/16

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2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

2-Chloropyrimidine-4-carboxamide is used as an organic synthesis and pharmaceutical intermediate.

Synthesis

149849-92-3

22536-66-9

General procedure for the synthesis of 2-chloropyrimidine-4-carboxamide from 2-chloropyrimidine-4-carboxylic acid: 2-chloropyrimidine-4-carboxylic acid (500 mg, 1.00 eq.) was dissolved in thionyl chloride (10 mL) and the reaction was heated to 90 °C for 30 min. Upon completion of the reaction, the excess thionyl chloride was removed by concentration under reduced pressure. The residue was cooled to 0 °C and ammonium hydroxide solution (20 mL) was slowly added. The reaction mixture was extracted with dichloromethane (20 mL x 3), the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 320 mg of 2-chloropyrimidine-4-carboxamide as a white solid. The product was analyzed by LC-MS (electrospray ionization, m/z): 158 [M+H]+.

References

[1] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 209

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Ethanol Potassium hydroxide Acetone Ethyl formate Hydrogen peroxide Sodium Phosphorus oxitrichloride Urea Sodium iodide Sodium nitrite Hydroquinone N,N-Dimethylaniline Diethyl ether Ethyl acetate Hydrochloric acid Acetic acid Bromoethane

Preparation Products

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View Lastest Price from 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-chloro-4-Pyrimidinecarboxamide 22536-66-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Shaanxi Dideu Medichem Co. Ltd

Product: 2-chloropyrimidine-4-carboxamide 22536-66-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Nanjing jinheyou Trading Co., Ltd.

Product: 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE 22536-66-9
Price: US $0.00/g
Min. Order: 1g
Purity: 95%min
Supply Ability: 20kg/month
Release date: 2019-12-19

22536-66-9, 2-CHLOROPYRIMIDINE-4-CARBOXAMIDERelated Search:

4-(Aminocarbonyl)-2-chloropyrimidine, 4-Carbamoyl-2-chloropyrimidine

2-Chloro-pyrimidine-4-carboxylic acid amide

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE

NSC 60802

2-chloro-4-Pyrimidinecarboxamide

4-Pyrimidinecarboxamide, 2-chloro-

22536-66-9

Building Blocks

Pyrimidine