ChemicalBook > CAS DataBase List > 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-

2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-

Product Name
2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
CAS No.
2468780-87-0
Chemical Name
2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
Synonyms
Lenalidomide-6-F;3-(6-Fluoro-1-oxo-2-isoindolinyl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-2,3-dihydro-1H-isoindol;3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione;2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
CBNumber
CB88367459
Molecular Formula
C13H11FN2O3
Formula Weight
262.24
MOL File
2468780-87-0.mol
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2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Property

Boiling point:
534.5±50.0 °C(Predicted)
Density 
1.461±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
pka
10.63±0.40(Predicted)
form 
Solid
color 
Gray to gray purple
InChI
InChI=1S/C13H11FN2O3/c14-8-2-1-7-6-16(13(19)9(7)5-8)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6H2,(H,15,17,18)
InChIKey
HNAQSGYWVZTYEF-UHFFFAOYSA-N
SMILES
N1C(=O)CCC(N2CC3=C(C2=O)C=C(F)C=C3)C1=O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Ambeed
Product number
A1469777
Product name
3-(6-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity
97%
Packaging
100mg
Price
$53
Updated
2021/12/16
Ambeed
Product number
A1469777
Product name
3-(6-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity
97%
Packaging
250mg
Price
$78
Updated
2021/12/16
Ambeed
Product number
A1469777
Product name
3-(6-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity
97%
Packaging
1g
Price
$191
Updated
2021/12/16
1Pluschem
Product number
1P01KCXQ
Product name
2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
Purity
97%
Packaging
250mg
Price
$276
Updated
2021/12/16
1Pluschem
Product number
1P01KCXQ
Product name
2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
Purity
97%
Packaging
5g
Price
$1235
Updated
2021/12/16
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2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Chemical Properties,Usage,Production

Uses

Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC[1].

IC 50

Cereblon

References

[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Suppliers

China 33 United States 1 Global 34
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58

2468780-87-0, 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-Related Search:

3-(5,6-difluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-Piperidinedione 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

  • 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
  • 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
  • Lenalidomide-6-F
  • 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-2,3-dihydro-1H-isoindol
  • 3-(6-Fluoro-1-oxo-2-isoindolinyl)piperidine-2,6-dione
  • 2468780-87-0
  • 468780-87-0