Suplatast tosilate

ChemicalBook > CAS DataBase List > Suplatast tosilate

Product Name: Suplatast tosilate
CAS No.: 94055-76-2
Chemical Name: Suplatast tosilate
Synonyms: Suplatast tosylate;IPD-1151T;Suplatast;SUPLATAST TOSILATE;Suplatast Tosylate >Methotrexate Impurity 47;Suplatast tosilate USP/EP/BP;Suplatast Tosylate (IPD 1151T);TIANFU CHEM--Suplatast tosilate;N,N-dimethyl-2-propyl-1-pentanamine
CBNumber: CB8837187
Molecular Formula: C23H33NO7S2
Formula Weight: 499.64062
MOL File: 94055-76-2.mol

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Suplatast tosilate Property

Melting point:: 84-87°C
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO: >20mg/mL
form: powder
color: white to off-white
Merck: 14,9003
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 94055-76-2(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: WR7906000
HS Code: 2930.90.2900
Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 81, 96, 96, 93 i.v.; in mice, rats (g/kg): >12.5, >10 orally (Yamashita)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4701
Product name: Suplatast tosylate
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $347
Updated: 2024/03/01

Sigma-Aldrich

Product number: S4701
Product name: Suplatast tosylate
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $77.6
Updated: 2022/05/15

TCI Chemical

Product number: S0875
Product name: Suplatast Tosylate
Purity: >98.0%(HPLC)(N)
Packaging: 100mg
Price: $51
Updated: 2024/03/01

TCI Chemical

Product number: S0875
Product name: Suplatast Tosylate
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $303
Updated: 2024/03/01

Cayman Chemical

Product number: 30316
Product name: Suplatast (tosylate)
Packaging: 50mg
Price: $68
Updated: 2024/03/01

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Suplatast tosilate Chemical Properties,Usage,Production

Description

Suplatast tosylate is a unique dimethylsulfonium salt marketed in Japan for the treatment of bronchial asthma, atopic dermatitis and allergic rhinitis. Suplatast tosylate is a potent inhibitor of IgE synthesis without suppressing IgM and IgG. The mechanism of action for suplatast tosylate is thought to be via the inhibition of interleukin-4 and interleukin-6 production by T-cells at the gene level. In allergic patients, suplatast tosylate markedly improved clinical symptoms which correlated with a significant decrease in serum IgE antibody levels.

Description

Suplatast is an antiallergic agent. It inhibits IL-4 and IL-5 production in conalbumin-stimulated D10.G4.1 murine T helper 2 (Th2) cells in a concentration-dependent manner. Suplatast (100 mg/kg) inhibits ovalbumin-induced increases in eosinophil and total cell numbers, as well as IL-4, IL-5, and IL-13, but not IFN-γ, levels in bronchoalveolar lavage fluid (BALF) in an ovalbumin-sensitized mouse model of asthma. It also inhibits ovalbumin-induced increases in ovalbumin-specific IgE in serum and bronchial hyperresponsiveness to methacholine in the ovalbumin-sensitized mouse model of asthma.

Originator

Taiho (Japan)

Uses

Suplatast Tosylate is an antiallergic drug. Suplatast Tosylate inhibits antigen-induced histamine release from mast cells as well as IgE antibody formation. Suplatast Tosylate suppresses interleukin (IL)-4 release from T cells, however in human peripheral basophils, Suplatast Tosylate inhibited the antigen-induced release of IL-13 but not IL-4.

Uses

Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.

brand name

IPD

Biological Activity

Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN- γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.

References

1) Kurokawa?et al.?(2001),?Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo; Mediators Inflamm.,?10?333 2) Hsu?et al.?(2007),?The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells; Transpl. Immunol.,?18?108 3) Furonaka?et al.?(2009),?Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice; Curr. Opin. J. Pharmacol. Exp. Ther.,?328?55 4) Bhattachrya?et al.?(2014),?Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis; J. Biol. Chem.,?289?33404 5) Wada?et al.?(2009),?Effect of suplatast tosilate on antileukotriene non-responders with mild-to-moderate persistent asthma; Allergol. Int.,?58?389

Suplatast tosilate Preparation Products And Raw materials

Raw materials

Preparation Products

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Suplatast tosilate Suppliers

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View Lastest Price from Suplatast tosilate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Suplatast Tosylate 94055-76-2
Price: US $0.01-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50 tons
Release date: 2020-04-24

Shanghai UCHEM Inc.

Product: Suplatast tosilate 94055-76-2
Price: US $65.40-800.00/g
Min. Order: 1g
Purity: 0.98
Supply Ability: 10kg
Release date: 2023-12-25

Hebei Mojin Biotechnology Co., Ltd

Product: Suplatast tosilate 94055-76-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-19

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(2-(4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl)ethyl)dimethylsulfonium p-toluenesulfonate

2-[4-(2-Hydroxy-3-ethoxypropoxy)phenylcarbamoyl]ethyldimethylsulfonium·4-methylbenzenesulfonate

IPD-1151T

S,S-Dimethyl-3-oxo-3-[4-(2-hydroxy-3-ethoxypropoxy)anilino]propane-1-sulfonium·4-methylbenzenesulfonate

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[2-[4-(2-Hydroxy-3-ethoxypropoxy)phenylcarbamoyl]ethyl]dimethylsulfonium

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2-[4-(2-Hydroxy-3-ethoxypropoxy)phenylcarbamoyl]ethyldimethylsulfonium

N-[4-(2-Hydroxy-3-ethoxypropoxy)phenyl]-3-(dimethylsulfonio)propanamide

SUPLATAST TOSILATE

Suplatast tosylate

[3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethylsulfonium4-methylbenzenesulfonate

Suplatast

[3-[[4-(3-ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl-sulfonium, 4-methylbenzenesulfonate (1:1)

N,N-dimethyl-2-propyl-1-pentanamine

Suplatast Tosylate &gt

High quality USP 39/EP 9.0 /BP 2012 GMP DMF FDA Suplatast tosilate CAS NO 18472-51-0 producer

Suplatast tosilate USP/EP/BP

Suplatast Tosylate (IPD 1151T)

TIANFU CHEM--Suplatast tosilate

3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl

Methotrexate Impurity 47

94055-76-2

C16H26NO4SC7H7O3S

C16H26NO4SC7H7O3SC23H

C16H26NO4SC7H7O3SC23H33NO7S2

C23H33NO7S2

API

Aromatics

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

IPD 1151T