1-Boc-4-ethynylpiperidine
Physical Form- Product Name
- 1-Boc-4-ethynylpiperidine
- CAS No.
- 287192-97-6
- Chemical Name
- 1-Boc-4-ethynylpiperidine
- Synonyms
- TERT-BUTYL 4-ETHYNYLPIPERIDINE-1-CARBOXYLATE;1-Boc-4-ethynylpiperidin;1-Boc-4-ethynylpiperidine;N-Boc-4-ethynylpiperidine;ert-butyl4-ethynylpiperidine-1-carboxylate;Tert-butyl4-ethynylpiperidin-1-carboxylate;tert-butyl 4-ethynyl-1-piperidinecarboxylate;4-Ethynyl-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-ethynyl-, 1,1-dimethylethyl ester;4-Ethynylpiperidine-1-carboxylic acid tert-butyl ester - [E0461]
- CBNumber
- CB8838917
- Molecular Formula
- C12H19NO2
- Formula Weight
- 209.28
- MOL File
- 287192-97-6.mol
1-Boc-4-ethynylpiperidine Property
- Boiling point:
- 269.6±29.0 °C(Predicted)
- Density
- 1.02±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.20±0.40(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C12H19NO2/c1-5-10-6-8-13(9-7-10)11(14)15-12(2,3)4/h1,10H,6-9H2,2-4H3
- InChIKey
- INUWDZDWSJJFSQ-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(C#C)CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B694565
- Product name
- tert-Butyl4-Ethynylpiperidine-1-carboxylate
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 263972
- Product name
- 1-Boc-4-ethynylpiperidine
- Packaging
- 50mg
- Price
- $410
- Updated
- 2021/12/16
- Product number
- CHM0371558
- Product name
- 1-BOC-4-ETHYNYLPIPERIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.63
- Updated
- 2021/12/16
- Product number
- AS12107
- Product name
- 1-Boc-4-ethynylpiperidine
- Purity
- 97+%
- Packaging
- 25g
- Price
- $750
- Updated
- 2021/12/16
- Product number
- B690
- Product name
- 1-Boc-4-ethynylpiperidine
- Packaging
- 25g
- Price
- $801
- Updated
- 2021/12/16
1-Boc-4-ethynylpiperidine Chemical Properties,Usage,Production
Physical Form
Solid
Chemical Properties
The structural formula of 1-Boc-4-ethynylpiperidine shows that its molecule contains a piperidine ring with an acetylenic group attached at position 4 and a tert-butoxycarbonyl (Boc) protecting group attached to the nitrogen atom of the piperidine. This structure gives 1-Boc-4-ethynylpiperidine its unique chemical properties and applications.
Uses
tert-Butyl 4-Ethynylpiperidine-1-carboxylate is a useful research chemical.
Synthesis
90965-06-3
137076-22-3
287192-97-6
A solution of dimethyl (1-diazido-2-oxopropyl)phosphonate (323 mg, 1.68 mmol) in methanol (2 mL) was added slowly and dropwise to a stirred mixture of 1-Boc-piperidine-4-carboxaldehyde (358 mg, 1.68 mmol) and potassium carbonate (464 mg, 3.36 mmol) in methanol (16 mL) at 0 °C. The reaction mixture was stirred overnight at room temperature and subsequently filtered and concentrated. The residue was purified by silica gel column chromatography using ethyl acetate/hexane (1:5, v/v) as eluent to afford 1-Boc-4-ynylpiperidine (308 mg, 88% yield) as colorless crystals.LC-MS m/z: 154 [M-Boc+2H]+. (Reference: J. Am. Chem. Soc. 2003, 125, 3714.)
References
[1] Journal of the American Chemical Society, 2003, vol. 125, # 13, p. 3714 - 3715
[2] Patent: WO2007/97937, 2007, A1. Location in patent: Page/Page column 191
[3] Patent: WO2008/156739, 2008, A1. Location in patent: Page/Page column 222
[4] Tetrahedron Letters, 2006, vol. 47, # 11, p. 1729 - 1731
[5] Medicinal Chemistry Research, 2018, vol. 27, # 11-12, p. 2437 - 2445
1-Boc-4-ethynylpiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-4-ethynylpiperidine Suppliers
- Tel
- 18602586511
- Fax
- 0519-85267382
- info@wateclaboratories.com
- Country
- China
- ProdList
- 170
- Advantage
- 60
- Tel
- 18817486326 18817486326;
- 3237528851@qq.com
- Country
- China
- ProdList
- 52
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44802
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7891
- Advantage
- 64
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- marketing@accelachem.com
- Country
- China
- ProdList
- 10977
- Advantage
- 64
- Tel
- 021-34975603-808 18721111801
- Fax
- +86-21-34975602-805
- sales@bocpharma.com
- Country
- China
- ProdList
- 994
- Advantage
- 64
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
View Lastest Price from 1-Boc-4-ethynylpiperidine manufacturers
- Product
- 1-Boc-4-ethynylpiperidine 287192-97-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-04
- Product
- 1-Boc-4-ethynylpiperidine 287192-97-6
- Price
- US $10.00/Kg/Bag
- Min. Order
- 10g
- Purity
- 99
- Supply Ability
- 1000KG
- Release date
- 2021-12-22
- Product
- 1-Boc-4-ethynylpiperidine 287192-97-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01