4-Methylumbelliferyl-beta-D-glucopyranoside

Product Name: 4-Methylumbelliferyl-beta-D-glucopyranoside
CAS No.: 18997-57-4
Chemical Name: 4-Methylumbelliferyl-beta-D-glucopyranoside
Synonyms: MUD;MUG;MU-Glu;MUGGAL;MU-GAL;7-(B2;4-MU-GLU;GLC1-B-4MU;MUGLUCOSIDE;4-MU-β-Gluc
CBNumber: CB8853266
Molecular Formula: C16H18O8
Formula Weight: 338.31
MOL File: 18997-57-4.mol

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4-Methylumbelliferyl-beta-D-glucopyranoside Property

Melting point:: 258-263 °C (dec.)
Boiling point:: 394.46°C (rough estimate)
Density: 1.522
refractive index: 1.4430 (estimate)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMF: 5 mg/ml; DMSO: 50 mg/ml
pka: 12.73±0.70(Predicted)
form: Powder
color: White to off-white
Water Solubility: Soluble in DMF or water
λmax: 320nm(Buffer)(lit.)
BRN: 94672
CAS DataBase Reference: 18997-57-4(CAS DataBase Reference)

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28
Safety Statements: 22-24/25
WGK Germany: 3
F: 3-10-21
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M3633
Product name: 4-Methylumbelliferyl β-D-glucopyranoside
Purity: β-glucosidase substrate
Packaging: 1g
Price: $485
Updated: 2024/03/01

Sigma-Aldrich

Product number: M3633
Product name: 4-Methylumbelliferyl β-D-glucopyranoside
Purity: β-glucosidase substrate
Packaging: 5g
Price: $1870
Updated: 2024/03/01

TCI Chemical

Product number: M3022
Product name: 4-Methylumbelliferyl β-D-Glucopyranoside
Purity: >98.0%(HPLC)
Packaging: 250mg
Price: $26
Updated: 2024/03/01

TCI Chemical

Product number: M3022
Product name: 4-Methylumbelliferyl β-D-Glucopyranoside
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $73
Updated: 2024/03/01

Alfa Aesar

Product number: J66630
Product name: 4-Methylumbelliferyl beta-D-glucopyranoside, 99%
Packaging: 1g
Price: $135
Updated: 2024/03/01

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4-Methylumbelliferyl-beta-D-glucopyranoside Chemical Properties,Usage,Production

Description

4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease. Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.

Chemical Properties

White Powder

Uses

A fluorogenic substrate in the assay of ?-glucosidase. Fluorescence: max. Abs. 316nm; max. Em. 372nm; e x 10-3: 15

Uses

A fluorogenic substrate in the assay of ?-glucosidase.Fluorescence: max. Abs. 316nm; max. Em. 372nm; e x 10-3: 15

Uses

4-Methylumbelliferyl β-D-glucopyranoside has been used as substrate:

in glucosylceramidase β enzyme activity assay in lysosome-enriched fractions from primary hippocampal neurons
in β-glucosidase assay during yeast fermentation
to assay glucocerebrosidase 1 (GBA1)-related glucosidase activity in macrophage cell line (RAW)

Definition

ChEBI: A beta-D-glucoside having a 4-methylumbelliferyl substituent at the anomeric position.

Biochem/physiol Actions

4-Methylumbelliferyl β-D-glucopyranoside is a synthetic enzymatic substrate for glycosidase. It has been used as substrate for the β- glucosidase from enterococci.

Purification Methods

4-Methylumbellifer-7-yl--Dglucopyranoside crystallises as the half hydrate from hot H2O. [Constantzas & Kocourek Collect Czech Chem Commun 24 1099 1959, De Re et al. Ann Chim (Rome) 4 9 2089 1959, Courtin-Duchateau & Veyrière Carbohydr Research 65 23, 29 1978, Beilstein 18 III/IV 5152, 8 IV 433, 18/7 V 616.]

4-Methylumbelliferyl-beta-D-glucopyranoside Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methylumbelliferyl-beta-D-glucopyranoside Suppliers

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View Lastest Price from 4-Methylumbelliferyl-beta-D-glucopyranoside manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Methylumbelliferyl-beta-D-glucopyranoside 18997-57-4
Price: US $0.00/G
Min. Order: 10G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-15

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Methylumbelliferyl-beta-D-glucopyranoside 18997-57-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 4-Methylumbelliferyl-beta-D-glucopyranoside 18997-57-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-18

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MUD

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