ChemicalBook > CAS DataBase List > 1-Methyl-1H-indole-6-carbaldehyde
1-Methyl-1H-indole-6-carbaldehyde
- Product Name
- 1-Methyl-1H-indole-6-carbaldehyde
- CAS No.
- 21005-45-8
- Chemical Name
- 1-Methyl-1H-indole-6-carbaldehyde
- Synonyms
- 6-Formyl-1-methylindole;1-Methylindole-6-carbaldehyde;1-Methyl-1H-indol-6-carbaldehyde;1-Methyl-1H-indole-6-carbaldehyd;1-METHYL-1H-INDOLE-6-CARBALDEHYDE;1-Methyl-1H-Indole-6-carboxaldehyde;1H-Indole-6-carboxaldehyde, 1-methyl-;1-Methyl-1H-indole-6-carboxaldehyde 97%;1-Methyl-1H-indole-6-carboxaldehyde;1H-Indole-6-carboxaldehyde, 1-methyl- (9CI)
- CBNumber
- CB8853327
- Molecular Formula
- C10H9NO
- Formula Weight
- 159.18
- MOL File
- 21005-45-8.mol
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1-Methyl-1H-indole-6-carbaldehyde Property
- Melting point:
- 81 °C
- Boiling point:
- 318.7±15.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- form
- solid
- Appearance
- Light yellow to brown Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 774502
- Product name
- 1-Methyl-1H-indole-6-carboxaldehyde
- Purity
- 97%
- Packaging
- 500mg
- Price
- $315
- Updated
- 2023/06/20
TRC
- Product number
- M313670
- Product name
- 1-Methylindole-6-carbaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR953712
- Product name
- 1-Methyl-1H-indole-6-carbaldehyde
- Purity
- 95%
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
AK Scientific
- Product number
- J97212
- Product name
- 1-Methyl-1H-indole-6-carbaldehyde
- Packaging
- 5g
- Price
- $270
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 036754
- Product name
- 1-Methyl-1H-indole-6-carbaldehyde
- Packaging
- 500mg
- Price
- $300
- Updated
- 2021/12/16
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1-Methyl-1H-indole-6-carbaldehyde Chemical Properties,Usage,Production
Uses
1-methyl-1H-indole-6-carbaldehyde is used as a component of organic synthesis or pharmaceutical intermediates.
Synthesis
1196-70-9
74-88-4
21005-45-8
GENERAL METHOD: Indole-6-carboxaldehyde (435 mg, 3 mmol) was dissolved in acetonitrile (30 mL), cesium carbonate (829 mg, 6 mmol) was added, and the reaction mixture was heated and refluxed for 2 hours. Subsequently, iodomethane (3.3 mmol) was added to the reaction system and heating and refluxing was continued for 1 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Water was added to the residue and extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the resulting residue was purified by fast column chromatography to give the target product 1-methylindole-6-carbaldehyde.
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 7, p. 2060 - 2079
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 19, p. 5888 - 5891
[3] Patent: WO2004/52890, 2004, A1. Location in patent: Page 46-47
1-Methyl-1H-indole-6-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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