Iminostilbene
- Product Name
- Iminostilbene
- CAS No.
- 256-96-2
- Chemical Name
- Iminostilbene
- Synonyms
- 5H-Dibenz[b,f]azepine;Iminostilben;5H-Dibenzo(b,f)azepine;CarbaMazepine Related CoMpound B;R-FMOC;RP 9989;IminostiL;NSC 123458;Iminostilbene;lminostilbene
- CBNumber
- CB8853392
- Molecular Formula
- C14H11N
- Formula Weight
- 193.24
- MOL File
- 256-96-2.mol
Iminostilbene Property
- Melting point:
- 197 °C
- Boiling point:
- 221 °C(lit.)
- Density
- 1.290 g/mL at 20 °C(lit.)
- refractive index
- n20/D 1.523(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- dioxane: 50 mg/mL, clear
- form
- powder
- pka
- 1.71±0.20(Predicted)
- color
- yellow to orange
- Water Solubility
- Soluble in ethyl acetate (25 mg/ml), water (partly), dioxane, chloroform, and DMSO.
- BRN
- 1343358
- LogP
- 4.06
- CAS DataBase Reference
- 256-96-2(CAS DataBase Reference)
- NIST Chemistry Reference
- o,o'-Iminostilbene(256-96-2)
- EPA Substance Registry System
- 5H-Dibenz[b,f]azepine (256-96-2)
Safety
- Hazard Codes
- C,Xi,N,Xn
- Risk Statements
- 34-51/53-22-36/37/38
- Safety Statements
- 26-36/37/39-45-61-27-24/25
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 10-21
- Hazard Note
- Irritant
- HS Code
- 29339900
N-Bromosuccinimide Price
- Product number
- 143650
- Product name
- 5H-Dibenz[b,f]azepine
- Purity
- 97%
- Packaging
- 1g
- Price
- $66.6
- Updated
- 2025/07/31
- Product number
- 1093023
- Product name
- Carbamazepine Related Compound B
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $1300
- Updated
- 2025/07/31
- Product number
- I0414
- Product name
- Iminostilbene
- Purity
- >98.0%(GC)(N)
- Packaging
- 5g
- Price
- $44
- Updated
- 2025/07/31
- Product number
- I0414
- Product name
- Iminostilbene
- Purity
- >98.0%(GC)(N)
- Packaging
- 25g
- Price
- $122
- Updated
- 2025/07/31
- Product number
- PHR1197
- Product name
- Iminostilbene: Carbamazepine Related Compound B
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500mg
- Price
- $517.75
- Updated
- 2025/07/31
Iminostilbene Chemical Properties,Usage,Production
Chemical Properties
Yellow to orange-yellow fine powder
Uses
Iminostilbene is mainly used as a pharmaceutical intermediate for the production of carbamazepine, Oxcarbazepine, and rhodium catalyst ligand. It is a metabolite of of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain.
Application
Iminostilbene has good antioxidant effects. N-acetyl iminostilbene was synthesized by incubating iminostilbene (2.0020 g, 10.360 mmol) with acetic anhydride.
Preparation
iminostilbene synthesis: 10,11-Dihydro-5-dibenz(b,f)azepine [Iminodibenzyl, 494-19-9] as raw material was acylated by triphosgene, after bromination by bromine and dehydrobromination, reacted with sodium hydroxide in isopropanol to give Iminostilbene.
Definition
ChEBI: Iminostilbene is a mancude organic heterotricyclic parent that consists of a seven-membered nitrogen hetrocycle fused with two benzene rings. It has a role as a marine xenobiotic metabolite. It is a mancude organic heterotricyclic parent and a dibenzoazepine.
General Description
5H-Dibenz[b,f]azepine, a tricyclic amine with a seven-membered ring, is commonly known as iminostilbene. It is used as an intermediate or a starting material in the synthesis of many anticonvulsant drugs.It is also used as a starting material to prepare pharmacologically important dibenzoazepine-pyridazine derivatives and synthesize olefinic multidentate ligand, which is used to prepare Rh(I) complexes.
Biochem/physiol Actions
2-(Bromomethyl)naphthalene is a fluorescent alkyl bromide. It causes the esterification of free carboxyl groups formed at the surface of polyethylene terephthalate by enzyme hydrolysis. It acts as organic electrophile in the P4S10/acyloin reaction.
Synthesis
19209-60-0
256-96-2
The general procedure for the synthesis of iminostilbene from N-acetyl iminostilbene was as follows: NaOH was stirred and mixed with triethylboron under argon protection at room temperature to form a clear and clarified solution with a concentration of 1 M/L. Subsequently, 10 μmol (2 mol%) of amide substrate, 5 mmol of triethoxysilane or polymethylhydrosiloxane (PMHS) were sequentially added to the above triethylboron solution. 15 mmol of the reaction mixture with 2 mL of methyl tert-butyl ether (MTBE) was added to a 10 mL sealed tube and heated and stirred in an oil bath at 80 °C for 6 hours. Upon completion of the reaction, the reaction system was exposed to air and the amine products were subsequently isolated directly by column chromatography. According to the column chromatographic separation, the yield of the target product iminostilbene was when triethoxysilane or polymethylhydrosiloxane (PMHS) was used as the reducing agent:
References
[1] Patent: CN107337573, 2017, A. Location in patent: Paragraph 0038; 0039; 0040; 0041
Iminostilbene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Iminostilbene manufacturers
- Product
- Iminostilbene 256-96-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-11
- Product
- Oxcarbazepine EP Impurity E 256-96-2
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%+
- Supply Ability
- 100000
- Release date
- 2025-01-17
- Product
- Iminostilbene 256-96-2
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-08-25