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Iminostilbene

Product Name
Iminostilbene
CAS No.
256-96-2
Chemical Name
Iminostilbene
Synonyms
5H-Dibenz[b,f]azepine;Iminostilben;5H-Dibenzo(b,f)azepine;CarbaMazepine Related CoMpound B;R-FMOC;RP 9989;IminostiL;NSC 123458;Iminostilbene;lminostilbene
CBNumber
CB8853392
Molecular Formula
C14H11N
Formula Weight
193.24
MOL File
256-96-2.mol
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Iminostilbene Property

Melting point:
197 °C
Boiling point:
221 °C(lit.)
Density 
1.290 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.523(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
dioxane: 50 mg/mL, clear
form 
powder
pka
1.71±0.20(Predicted)
color 
yellow to orange
Water Solubility 
Soluble in ethyl acetate (25 mg/ml), water (partly), dioxane, chloroform, and DMSO.
BRN 
1343358
LogP
4.06
CAS DataBase Reference
256-96-2(CAS DataBase Reference)
NIST Chemistry Reference
o,o'-Iminostilbene(256-96-2)
EPA Substance Registry System
5H-Dibenz[b,f]azepine (256-96-2)
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Safety

Hazard Codes 
C,Xi,N,Xn
Risk Statements 
34-51/53-22-36/37/38
Safety Statements 
26-36/37/39-45-61-27-24/25
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
10-21
Hazard Note 
Irritant
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
143650
Product name
5H-Dibenz[b,f]azepine
Purity
97%
Packaging
1g
Price
$66.6
Updated
2025/07/31
Sigma-Aldrich
Product number
1093023
Product name
Carbamazepine Related Compound B
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$1300
Updated
2025/07/31
TCI Chemical
Product number
I0414
Product name
Iminostilbene
Purity
>98.0%(GC)(N)
Packaging
5g
Price
$44
Updated
2025/07/31
TCI Chemical
Product number
I0414
Product name
Iminostilbene
Purity
>98.0%(GC)(N)
Packaging
25g
Price
$122
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR1197
Product name
Iminostilbene: Carbamazepine Related Compound B
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$517.75
Updated
2025/07/31
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Iminostilbene Chemical Properties,Usage,Production

Chemical Properties

Yellow to orange-yellow fine powder

Uses

Iminostilbene is mainly used as a pharmaceutical intermediate for the production of carbamazepine, Oxcarbazepine, and rhodium catalyst ligand. It is a metabolite of of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain.

Application

Iminostilbene has good antioxidant effects. N-acetyl iminostilbene was synthesized by incubating iminostilbene (2.0020 g, 10.360 mmol) with acetic anhydride.

Preparation

iminostilbene synthesis: 10,11-Dihydro-5-dibenz(b,f)azepine [Iminodibenzyl, 494-19-9] as raw material was acylated by triphosgene, after bromination by bromine and dehydrobromination, reacted with sodium hydroxide in isopropanol to give Iminostilbene.

Definition

ChEBI: Iminostilbene is a mancude organic heterotricyclic parent that consists of a seven-membered nitrogen hetrocycle fused with two benzene rings. It has a role as a marine xenobiotic metabolite. It is a mancude organic heterotricyclic parent and a dibenzoazepine.

General Description

5H-Dibenz[b,f]azepine, a tricyclic amine with a seven-membered ring, is commonly known as iminostilbene. It is used as an intermediate or a starting material in the synthesis of many anticonvulsant drugs.It is also used as a starting material to prepare pharmacologically important dibenzoazepine-pyridazine derivatives and synthesize olefinic multidentate ligand, which is used to prepare Rh(I) complexes.

Biochem/physiol Actions

2-(Bromomethyl)naphthalene is a fluorescent alkyl bromide. It causes the esterification of free carboxyl groups formed at the surface of polyethylene terephthalate by enzyme hydrolysis. It acts as organic electrophile in the P4S10/acyloin reaction.

Synthesis

19209-60-0

256-96-2

The general procedure for the synthesis of iminostilbene from N-acetyl iminostilbene was as follows: NaOH was stirred and mixed with triethylboron under argon protection at room temperature to form a clear and clarified solution with a concentration of 1 M/L. Subsequently, 10 μmol (2 mol%) of amide substrate, 5 mmol of triethoxysilane or polymethylhydrosiloxane (PMHS) were sequentially added to the above triethylboron solution. 15 mmol of the reaction mixture with 2 mL of methyl tert-butyl ether (MTBE) was added to a 10 mL sealed tube and heated and stirred in an oil bath at 80 °C for 6 hours. Upon completion of the reaction, the reaction system was exposed to air and the amine products were subsequently isolated directly by column chromatography. According to the column chromatographic separation, the yield of the target product iminostilbene was when triethoxysilane or polymethylhydrosiloxane (PMHS) was used as the reducing agent:

References

[1] Patent: CN107337573, 2017, A. Location in patent: Paragraph 0038; 0039; 0040; 0041

Iminostilbene Preparation Products And Raw materials

Raw materials

Diphenyl Aza

Preparation Products

Carbamazepine Iminodibenzylcarbonyl chloride Dibenz[b,f]azepine-5-carbonyl chloride
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Iminostilbene Suppliers

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View Lastest Price from Iminostilbene manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Iminostilbene 256-96-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-11
Moxin Chemicals
Product
Oxcarbazepine EP Impurity E 256-96-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%+
Supply Ability
100000
Release date
2025-01-17
Henan Bao Enluo International TradeCo.，LTD
Product
Iminostilbene 256-96-2
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-08-25

256-96-2, IminostilbeneRelated Search:

Iminodibenzyl EC 2.6.1.2 Iminodiacetonitrile Acetaminophen Iminodiacetic acid Dibenz[b,f]azepine-5-carbonyl chloride 10-Methoxy-2,2'-iminostilbene,10-METHOXY IMINOSTILBENE Depramine Amezepine OPIPRAMOL DIHYDROCHLORIDE 5-Cyano-5H-dibenz[b,f]azepine Iminostilbene-N-carboxamide N-[3-[4-(2-hydroxyethyl)piperazino]propyl]iminostilbene 2,2'-IMINOSTILBENE 10-Methoxy Iminostilbene Carbonylchloride Cycloheptatriene Bromine 3-Hydroxy Carbamazepine

  • 2,3,6,7-Dibenzazepine
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  • CarbaMazepine Related CoMpound B
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  • Carbamazepine Impurity 4(Carbamazepine EP Impurity D）
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  • 5H-Dibenz[b,f]azepin
  • 5H-Dibenzo(b,f)azepine
  • Dibenz(b,f)azepine
  • Stilbene, 2,2'-imino-
  • (-)-O-FORMYL-D-MANDELOYL CHLORIDE
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  • D(-)ALPHA-FORMYLOXY-ALPHA-PHENYLACETYLCHLORIDE
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  • IMINOSTILBENE (BROMINE FREE)
  • IMINOSTILBENE (NON-BROMINE FREE)
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  • Carbamazepine Impurity 4
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  • Iminostilbene DISCONTINUED, offer I445000
  • Iminostilbene (Oxcarbazepine Impurity)
  • Carbamazepine EP Impurity D/ Carbamazepine Related Compound B (Oxcarbazepine EP Impurity E/ Iminostilbene)
  • Oxcarbazapine Impurity E
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  • Oxcarbazepine impurities101
  • Oxcarbazepine impurities2
  • IminostilbeneQ: What is Iminostilbene Q: What is the CAS Number of Iminostilbene Q: What is the storage condition of Iminostilbene Q: What are the applications of Iminostilbene
  • Carbamazepine Related Compound B (Iminostilbene) (1093023)
  • lminostilbene
  • Carbamazepine USP Related Compound B
  • Carbamazepine EP Impurity D(Oxcarbazepine EP Impurity E)
  • Carbamazepine EP Impurity D (Carbamazepine USP Related Compound B, Iminostilbene)
  • Iminostilbene, ≥ 98.0%
  • Iminostilbene (ISB)