5-Methoxy-isobenzofuran-1,3-dione

Product Name: 5-Methoxy-isobenzofuran-1,3-dione
CAS No.: 28281-76-7
Chemical Name: 5-Methoxy-isobenzofuran-1,3-dione
Synonyms: 5-Methoxy-isobenzofuran-1;5-Methoxy-2-benzofuran-1,3-dione;5-Methoxy-1,3-isobenzofurandione;5-Methoxy-isobenzofuran-1,3-dione;1,3-Isobenzofurandione, 5-methoxy-;METHYL N-(DIPHENYLMETHYLENE)-L-SERINATE;5-Methoxy-1,3-dihydro-2-benzofuran-1,3-dione
CBNumber: CB8875206
Molecular Formula: C9H6O4
Formula Weight: 178.14
MOL File: 28281-76-7.mol

More

Less

5-Methoxy-isobenzofuran-1,3-dione Property

Melting point:: 98-99 °C(Solv: acetic acid (64-19-7))
Boiling point:: 348.6±25.0 °C(Predicted)
Density: 1.407±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to light yellow Solid

More

Less

Safety

HS Code: 2932990090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: M262975
Product name: 5-Methoxyisobenzofuran-1,3-dione
Packaging: 1g
Price: $250
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H26-1-0H
Product name: 5-Methoxyisobenzofuran-1,3-dione
Purity: 95%
Packaging: 250mg
Price: $256
Updated: 2021/12/16

Matrix Scientific

Product number: 072796
Product name: 5-Methoxyisobenzofuran-1,3-dione
Purity: 95+%
Packaging: 1g
Price: $462
Updated: 2021/12/16

AK Scientific

Product number: J95297
Product name: 5-Methoxy-isobenzofuran-1,3-dione
Packaging: 25g
Price: $540
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H26-1-0H
Product name: 5-Methoxyisobenzofuran-1,3-dione
Purity: 95%
Packaging: 1g
Price: $632
Updated: 2021/12/16

More

Less

5-Methoxy-isobenzofuran-1,3-dione Chemical Properties,Usage,Production

Uses

5-Methoxyisobenzofuran-1,3-dione is used as a reagent in the synthesis of basic ethers of 1,2-dihydropyrrolo[1,2-α]indole, 6H-isoindolo[2,1-α]indole, and 6H-benz[5,6]isoindolo[2,1-α]indole which display antiproliferative activity.

Synthesis

1885-13-8

28281-76-7

The general procedure for the synthesis of 5-methoxyisobenzofuran-1,3-dione using 4-methoxyphthalic acid as starting material was as follows: acetic anhydride (40 mL) was slowly added to a solution of anhydrous tetrahydrofuran (150 mL) containing 4-methoxyphthalic acid (30.8 g, 0.16 mol). The reaction mixture was refluxed with stirring for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently evaporated under reduced pressure to afford 4-methoxyphthalic anhydride (27.8 g, 99% yield) as an off-white solid. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 8.02 (1H, d), 7.59 (1H, d), 7.49 (1H, dd), 3.97 (3H, s). Mass spectrometry analysis showed the [M + H]+ peak at 179.

References

[1] Patent: WO2008/44029, 2008, A1. Location in patent: Page/Page column 204
[2] Patent: WO2008/44041, 2008, A1. Location in patent: Page/Page column 225-226
[3] Patent: WO2008/44045, 2008, A1. Location in patent: Page/Page column 277-278
[4] Patent: WO2008/44054, 2008, A2. Location in patent: Page/Page column 122
[5] Patent: US2010/152184, 2010, A1. Location in patent: Page/Page column 72; 73

5-Methoxy-isobenzofuran-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-Methoxy-isobenzofuran-1,3-dione Suppliers

China 85 India 3 United Kingdom 1 United States 10 Global 99

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Abblis Chemicals LLC

Tel: --
Fax: --
Email: info@abblis.com
Country: United States
ProdList: 1272
Advantage: 0

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

More

Less

View Lastest Price from 5-Methoxy-isobenzofuran-1,3-dione manufacturers

Career Henan Chemical Co

Product: 5-Methoxy-isobenzofuran-1,3-dione 28281-76-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

28281-76-7, 5-Methoxy-isobenzofuran-1,3-dioneRelated Search:

Benzofuran AKOS 212-66 4,4'-Oxydiphthalic anhydride AKOS 227-92 AKOS 215-94 4,4'-(3,4-DICARBOXYPHENOXY)DIPHENYLSULFIDE DIANHYDRIDE 4,4'-(4,4'-ISOPROPYLIDENEDIPHENOXY)BIS(PHTHALIC ANHYDRIDE) AKOS 200-04 AKOS 220-67 AKOS 243-36 5-Methoxy-isobenzofuran-1,3-dione AKOS 220-69 HQDA

5-Methoxy-1,3-dihydro-2-benzofuran-1,3-dione

METHYL N-(DIPHENYLMETHYLENE)-L-SERINATE

1,3-Isobenzofurandione, 5-methoxy-

5-Methoxy-2-benzofuran-1,3-dione

5-Methoxy-isobenzofuran-1,3-dione

5-Methoxy-isobenzofuran-1

5-Methoxy-1,3-isobenzofurandione

28281-76-7