lucanthone
- Product Name
- lucanthone
- CAS No.
- 479-50-5
- Chemical Name
- lucanthone
- Synonyms
- Lucantona;lucanthone;Lycanthone;Lucanthonum;Lucanthone, 10 mM in DMSO;Autophagy,inhibit,Lucanthone,Inhibitor;1-(2-diethylaminoethylamino)-4-(methyl)thioxanthen-9-one;1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one;9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-
- CBNumber
- CB8875332
- Molecular Formula
- C20H24N2OS
- Formula Weight
- 340.48
- MOL File
- 479-50-5.mol
lucanthone Property
- Melting point:
- 64.5°C
- Boiling point:
- 512.4±50.0 °C(Predicted)
- Density
- 1.0915 (rough estimate)
- refractive index
- 1.5950 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 25 mg/mL (73.43 mM)
- form
- Solid
- pka
- 10.00±0.25(Predicted)
- color
- Off-white to orange
N-Bromosuccinimide Price
- Product number
- API0005244
- Product name
- LUCANTHONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.16
- Updated
- 2021/12/16
- Product number
- A737309
- Product name
- 1-((2-(Diethylamino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one
- Purity
- 99+%
- Packaging
- 25mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- A737309
- Product name
- 1-((2-(Diethylamino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one
- Purity
- 99+%
- Packaging
- 50mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- A737309
- Product name
- 1-((2-(Diethylamino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one
- Purity
- 99+%
- Packaging
- 100mg
- Price
- $285
- Updated
- 2021/12/16
lucanthone Chemical Properties,Usage,Production
Uses
Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).
Definition
ChEBI: Lucanthone is a thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. It has a role as a schistosomicide drug, an antineoplastic agent, a photosensitizing agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a prodrug, an adjuvant and a mutagen.
Safety Profile
Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.
References
[1] Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18. DOI:10.1016/j.nano.2014.08.001
[2] Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13. DOI:10.1074/jbc.M110.151324
lucanthone Preparation Products And Raw materials
Raw materials
Preparation Products
lucanthone Suppliers
- Tel
- --
- Fax
- --
- mktg@pharmaffiliates.com
- Country
- India
- ProdList
- 6739
- Advantage
- 58