fenspiride
- Product Name
- fenspiride
- CAS No.
- 5053-06-5
- Chemical Name
- fenspiride
- Synonyms
- DESP;FUBMN24;FUB-MN24;Fenspirid;fenspiride;Fenspiridum;Fenspiride-d5;fenspiride USP/EP/BP;8-phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one;Pharmaceutical intermediates BKEDBP BKEDBP bkedbp
- CBNumber
- CB8875352
- Molecular Formula
- C15H20N2O2
- Formula Weight
- 260.33
- MOL File
- 5053-06-5.mol
fenspiride Property
- Boiling point:
- 126-127 °C(Press: 2 Torr)
- Density
- 1.19±0.1 g/cm3(Predicted)
- pka
- 12.44±0.20(Predicted)
- form
- Solid:particulate/powder
- LogP
- 1.798-1.802 at 20℃ and pH6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S040
- Product name
- Fenspiride
- Packaging
- 1g
- Price
- $384
- Updated
- 2021/12/16
- Product number
- RDL0006831
- Product name
- FENSPIRIDE-D5
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.31
- Updated
- 2021/12/16
- Product number
- S040
- Product name
- Fenspiride
- Packaging
- 5g
- Price
- $1051
- Updated
- 2021/12/16
- Product number
- D74913
- Product name
- Fenspiride-d5
- Packaging
- 5mg
- Price
- $1490
- Updated
- 2021/12/16
- Product number
- 60R0505
- Product name
- 8-Phenethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $3998
- Updated
- 2021/12/16
fenspiride Chemical Properties,Usage,Production
Originator
Viarespan,Servier,France,1969
Uses
Bronchodilator;anti-adrenergic (β-receptor).
Definition
ChEBI: 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one is an azaspiro compound.
Manufacturing Process
A solution of 192 g of 1-phenethyl-4-hydroxy-4-aminomethyl piperidine in 800
cc of diethylcarbonate is heated for 2? hours to reflux at about 80°C in the
presence of sodium methylate (prepared for immediate use from 2 g of
sodium). After this time, the ethyl alcohol formed during the reaction is slowly
distilled while the maximum temperature is reached. The excess ethyl
carbonate is distilled under reduced pressure. A crystallized residue is then
obtained, which is stirred with 400 cc of water and 400 cc of ether. The
solution is filtered and 125 g (77.6%) of practically pure product melting at
232°C to 233°C, are obtained.
The starting material was prepared in a yield of 58% by reduction of the
corresponding cyanohydrin. It in turn was prepared from 1-(2-phenylethyl)-4-
piperidone and potassium cyanide to give the cyanohydrin which was reduced
by lithium aluminum hydride.
Therapeutic Function
Bronchodilator
Pharmaceutical Applications
Fenspiride is an antagonist of 5-hydroxytryptamine, whose effect on bronchial smooth muscle expansion is between isoproterenol and theophylline. It also has the effect of unobtrusion-free respiratory tract and air resistance elimination in the lungs. It has the effect of antitussive, antipyretic, analgesic and anti-inflammatory, and the antipyretic and analgesic effect is better than aminopyrine and the anti-inflammatory effect is stronger than bute.
fenspiride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from fenspiride manufacturers
- Product
- Fenspiride 5053-06-5
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-06-28
- Product
- fenspiride 5053-06-5
- Price
- US $25.00/KG
- Min. Order
- 100g
- Purity
- 99.99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-11-24
- Product
- Fenspiride 5053-06-5
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%min
- Supply Ability
- 5000
- Release date
- 2021-04-16