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Lorcainide

Product Name
Lorcainide
CAS No.
59729-31-6
Chemical Name
Lorcainide
Synonyms
R-15889;Lorcamide;Lopantrol;Ro-13。1042;Lorcainide;Lorivox:Remivox;Lorcainide USP/EP/BP;N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide;N-(4-Chlorophenyl)-N-[1-(1-methylethyl)piperidin-4-yl]benzeneacetamide;N-(4-Chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide
CBNumber
CB8875468
Molecular Formula
C22H27ClN2O
Formula Weight
370.92
MOL File
59729-31-6.mol
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Lorcainide Property

Melting point:
263 °C
Boiling point:
503.0±50.0 °C(Predicted)
Density 
1.161±0.06 g/cm3(Predicted)
pka
9.48±0.20(Predicted)
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Safety

Toxicity
LD50 in male mice, male and female rats (mg/kg): 18.8, 19.3, 18.6 i.v.; 483, 395, 435 orally (Barton, Marsboom)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0003213
Product name
LORCAINIDE
Purity
95.00%
Packaging
5MG
Price
$495.53
Updated
2021/12/16
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Lorcainide Chemical Properties,Usage,Production

Originator

Remivox,Janssen,W. Germany,1980

Uses

Cardiac depressant (anti-arrhythmic).

Definition

ChEBI: Lorcainide is a member of acetamides.

Manufacturing Process

To a stirred suspension of 5 parts of N-(4-chlorophenyl)-N-(4-piperidinyl) benzeneacetamide, 5 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of butanol is added dropwise 4 parts of 2-bromopropane at room temperature. After the addition is complete, the whole is stirred and refluxed for 20 hours. Then the second portion of 4 parts of 2-bromopropane is added and stirring and refluxing is continued for another 19 hours. The reaction mixture is cooled, filtered and the filtrate is evaporated. From the oily free base, the hydrochloride salt is prepared in the conventional manner in 1,1'-oxybisethane and 2-propanone. The precipitated solid salt is filtered off and crystallized from a mixture of 2-propanone and 2-propanol, yielding 2 parts of N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl] benzeneacetamide hydrochloride; melting point 263°C.

Therapeutic Function

Antiarrhythmic

Side effects

Side effects include insomnia and gastrointestinal disturbances.

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Lorcainide Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
DebyeTec.com Inc.
Tel
18086626237 18086626237
Fax
qq:2693528373
Email
sales@debyesci.com
Country
China
ProdList
2644
Advantage
56
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Sinoway Industrial co., ltd.
Tel
0592-5800732; +8613806035118
Fax
0592-5854960
Email
xie@china-sinoway.com
Country
China
ProdList
988
Advantage
58

59729-31-6, LorcainideRelated Search:


  • Lorcainide
  • N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide
  • Lopantrol
  • Lorivox:Remivox
  • N-(4-Chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide
  • R-15889
  • Ro-13。1042
  • N-(4-Chlorophenyl)-N-[1-(1-methylethyl)piperidin-4-yl]benzeneacetamide
  • BenzeneacetaMide,N-(4-chlorophenyl)-N-[1-(1-Methylethyl)-4-piperidinyl]-
  • Lorcamide
  • Lorcainide USP/EP/BP
  • 59729-31-6
  • C22H27ClN2O