Lorcainide
- Product Name
- Lorcainide
- CAS No.
- 59729-31-6
- Chemical Name
- Lorcainide
- Synonyms
- R-15889;Lorcamide;Lopantrol;Ro-13。1042;Lorcainide;Lorivox：Remivox;Lorcainide USP/EP/BP;N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide;N-(4-Chlorophenyl)-N-[1-(1-methylethyl)piperidin-4-yl]benzeneacetamide;N-(4-Chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide
- CBNumber
- CB8875468
- Molecular Formula
- C22H27ClN2O
- Formula Weight
- 370.92
- MOL File
- 59729-31-6.mol
Lorcainide Property
- Melting point:
- 263 °C
- Boiling point:
- 503.0±50.0 °C(Predicted)
- Density
- 1.161±0.06 g/cm3(Predicted)
- pka
- 9.48±0.20(Predicted)
Safety
- Toxicity
- LD50 in male mice, male and female rats (mg/kg): 18.8, 19.3, 18.6 i.v.; 483, 395, 435 orally (Barton, Marsboom)
N-Bromosuccinimide Price
- Product number
- API0003213
- Product name
- LORCAINIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.53
- Updated
- 2021/12/16
Lorcainide Chemical Properties,Usage,Production
Originator
Remivox,Janssen,W. Germany,1980
Uses
Cardiac depressant (anti-arrhythmic).
Definition
ChEBI: Lorcainide is a member of acetamides.
Manufacturing Process
To a stirred suspension of 5 parts of N-(4-chlorophenyl)-N-(4-piperidinyl) benzeneacetamide, 5 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of butanol is added dropwise 4 parts of 2-bromopropane at room temperature. After the addition is complete, the whole is stirred and refluxed for 20 hours. Then the second portion of 4 parts of 2-bromopropane is added and stirring and refluxing is continued for another 19 hours. The reaction mixture is cooled, filtered and the filtrate is evaporated. From the oily free base, the hydrochloride salt is prepared in the conventional manner in 1,1'-oxybisethane and 2-propanone. The precipitated solid salt is filtered off and crystallized from a mixture of 2-propanone and 2-propanol, yielding 2 parts of N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl] benzeneacetamide hydrochloride; melting point 263°C.
Therapeutic Function
Antiarrhythmic
Side effects
Side effects include insomnia and gastrointestinal disturbances.
Lorcainide Preparation Products And Raw materials
Raw materials
Preparation Products
Lorcainide Suppliers
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- 1-(800)-881-8210
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View Lastest Price from Lorcainide manufacturers
- Product
- Lorcainide 59729-31-6
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-11
- Product
- Lorcainide 59729-31-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-11