N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
- Product Name
- N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
- CAS No.
- 58934-46-6
- Chemical Name
- N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
- Synonyms
- Nsc310411;Lorcainide HCl;EINECS 261-504-6;Isocainide hydrochloride;LORCAINIDE HYDROCHLORIDE;4'-Chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide monohydrochloride;N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride;N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride USP/EP/BP;Benzeneacetamide, N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]-, monohydrochloride
- CBNumber
- CB3904853
- Molecular Formula
- C22H28Cl2N2O
- Formula Weight
- 407.37652
- MOL File
- 58934-46-6.mol
N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Property
- Melting point:
- 263°
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 20 mg/ml), in Water (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml).
- form
- White solid.
- color
- Powder
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 1 month
N-Bromosuccinimide Price
- Product number
- J67098
- Product name
- Lorcainide hydrochloride, 98%
- Packaging
- 10mg
- Price
- $126
- Updated
- 2021/12/16
- Product number
- HCH0041839
- Product name
- N-(4-CHLOROPHENYL)-2-PHENYL-N-(1-PROPAN-2-YL-3,4,5,6-TETRAHYDRO-2H-PYRIDIN-4-YL)ACETAMIDE CHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.72
- Updated
- 2021/12/16
N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Chemical Properties,Usage,Production
Description
Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+?channel blocker.1?Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2?Acts at the ouabain binding site of guinea pig cardiac Na+/K+?ATPase and inhibits the enzyme (IC50?= 34 μM).3
Uses
Cardiac depressant (anti-arrhythmic).
References
1) Sheldon?et al.?(1989),?Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem.,?35?748 2) Lynch?et al.?(1995),?Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther.,?273?554 3) Almotrefi?et al. (1999),?Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol.,?77?866
N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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