2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide

2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Property

Melting point:

128-131 °C

Boiling point:

359.4±17.0 °C(Predicted)

Density 

1.309±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 2mg/mL, clear

form 

Solid

pka

10.14±0.23(Predicted)

color 

Light yellow to yellow

Hazard and Precautionary Statements (GHS)

2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Chemical Properties,Usage,Production

Uses

PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).

Biological Activity

PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1). PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μμ; 24 hours) increases apoptosis in RH4 and SCMC cells[1].

IC 50

KDM3

References

[1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.