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Garenoxacin

Product Name
Garenoxacin
CAS No.
223652-90-2
Chemical Name
Garenoxacin
Synonyms
Garenoxacin mesylate [USAN];BMS284756 (Mesylate hydrate);Garenoxacin mesylate hydrate;Garenoxacin mesylate monohydrate;Garenoxacin mesylate hydrate, 10 mM in DMSO;Garenoxacin mesylate monohydrate >=98% (HPLC);1-cyclopropyl-8-(difluoromethoxy)-4-keto-7-[(1R)-1-methylisoindolin-5-yl]quinoline-3-carboxylic acid;1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylicacid,methanesulfonicacid,hydrate;1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate;(R)-1-cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound with methanesulfonic acid (1:1) hydrate
CBNumber
CB8947028
Molecular Formula
C23H20F2N2O4.CH4O3S.H2O
Formula Weight
540.53
MOL File
223652-90-2.mol
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Garenoxacin Property

storage temp. 
2-8°C
solubility 
DMSO:100.0(Max Conc. mg/mL);185.0(Max Conc. mM)
Water:12.5(Max Conc. mg/mL);23.13(Max Conc. mM)
form 
powder
color 
white to beige
Water Solubility 
H2O: 10mg/mL, clear (warmed)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P314Get medical advice/attention if you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1618
Product name
Garenoxacin mesylate monohydrate
Purity
≥98% (HPLC)
Packaging
10mg
Price
$111
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1618
Product name
Garenoxacin mesylate monohydrate
Purity
≥98% (HPLC)
Packaging
50mg
Price
$447
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
API0013697
Product name
GARENOXACIN MESYLATE HYDRATE
Purity
95.00%
Packaging
1G
Price
$993.3
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013697
Product name
GARENOXACIN MESYLATE HYDRATE
Purity
95.00%
Packaging
2G
Price
$1309
Updated
2021/12/16
ChemScene
Product number
CS-4990
Product name
GarenoxacinMesylatehydrate
Purity
99.78%
Packaging
10mg
Price
$132
Updated
2021/12/16
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Garenoxacin Chemical Properties,Usage,Production

Uses

Antibacterial agent.

Biological Activity

Garenoxacin is a broad spectrum fluoroquinolone antibiotic suitable for treatment of gram-positive and gram-negative bacterial infections. Garenoxacin has a low mutant prevention concentration and a narrow mutant selection window. Data shows th at garenoxacin has anti-inflammatory properties. It significantly alleviates LPS-induced IL-8 production through the negative regulation of the ERK1/2 pathway both in the human airway epithelial cell line A549 and the monocyte cell line THP-1.

in vivo

Garenoxacin (12.5-50 mg/kg; s.c.; once) is highly effective against the wild-type strain and mutants harboring a single mutation in a mouse pneumonia model with S. pneumoniainfection[4].
Garenoxacin (10 and 30 mg/kg; p.o.; once) reduces the viable cell counts in the lungs and significantly prolongs survival on experimental secondary pneumococcal pneumonia caused by S. pneumoniae D-979 in BALB/c female mice[5].

Animal Model:Swiss mice with S. pneumonia infection[4].
Dosage:12.5, 25 and 50 mg/kg
Administration:Subcutaneous injection, once
Result:Significantly improved the survival rate.

IC 50

Quinolone; Gyrase: 1.25 μg/mL (IC50); TOPO IV: 1.5-2.5 μg/mL (IC50)

Garenoxacin Preparation Products And Raw materials

Raw materials

Preparation Products

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Garenoxacin Suppliers

China 63 India 1 South Korea 1 United Kingdom 1 United States 8 Global 74
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
BePharm Ltd
Tel
400-685-9117
Fax
021-51816740
Email
market@bepharm.com
Country
China
ProdList
15081
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
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View Lastest Price from Garenoxacin manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Garenoxacin Mesylate Hydrate 223652-90-2
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-11-15
Career Henan Chemical Co
Product
Garenoxacin 223652-90-2
Price
US $1000.00/KG
Min. Order
25KG
Purity
99%
Supply Ability
10tons
Release date
2018-07-26

223652-90-2, Garenoxacin Related Search:

Garethelin Intermediate 1 Garenoxacin Mesilate Hydrate iMpurity 2,3-Dihydro-(1R)-methyl-5-(tetrahydro-4H-1,3,6,2-dioxazaborocin-2-yl)-2-(triphenylmethyl)-1H-isoindole (1R)-5-bromo-2,3-dihydro-1-methyl-1H-Isoindole Garenoxacin Mesilate Hydrate impurity D Galesarin intermediate 3 1-PROPANONE, 1-[(1R)-5-BROMO-1,3-DIHYDRO-1-METHYL-2H-ISOINDOL-2-YL]-2,2-DIMETHYL- (R)-(1-methyl-2-tritylisoindolin-5-yl)boronic acid Galesarin intermediate 2 Garenoxacin GARENOXACIN MESYLATE

  • 1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate
  • Garenoxacin mesylate hydrate
  • Garenoxacin mesylate hydrate 1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate
  • (R)-1-cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound with methanesulfonic acid (1:1) hydrate
  • 1-cyclopropyl-8-(difluoromethoxy)-4-keto-7-[(1R)-1-methylisoindolin-5-yl]quinoline-3-carboxylic acid
  • BMS284756 (Mesylate hydrate)
  • Garenoxacin mesylate [USAN]
  • Garenoxacin mesylate monohydrate >=98% (HPLC)
  • 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylicacid,methanesulfonicacid,hydrate
  • Garenoxacin mesylate hydrate,DNA/RNA Synthesis,Topoisomerase,S. pneumonia,S. aureus,gyrase,Garenoxacin Mesylate,ureaplasmas,Inhibitor,BMS284756 Mesylate,topoisomerase IV,Swiss mice,inhibit,Bacterial,mycoplasmas,Antibiotic
  • Garenoxacin mesylate monohydrate
  • Garenoxacin mesylate hydrate, 10 mM in DMSO
  • 223652-90-2
  • C24H26F2N2O8S
  • C23H20F2N2O4CH4O3SH2O