4-(2-hydroxyethyl)benzoic acid
- Product Name
- 4-(2-hydroxyethyl)benzoic acid
- CAS No.
- 46112-46-3
- Chemical Name
- 4-(2-hydroxyethyl)benzoic acid
- Synonyms
- 4-(2-Hydroxyethyl);4-(2-Hydroxyethyl)benzoic acid;Benzoic acid, 4-(2-hydroxyethyl)-;4-(2-Hydroxyethyl)benzoic acid 95%
- CBNumber
- CB8947134
- Molecular Formula
- C9H10O3
- Formula Weight
- 166.17
- MOL File
- 46112-46-3.mol
4-(2-hydroxyethyl)benzoic acid Property
- Melting point:
- 127-128 °C
- Boiling point:
- 345.8±25.0 °C(Predicted)
- Density
- 1.256±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.26±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H515390
- Product name
- 4-(2-Hydroxyethyl)benzoicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2629-1-97
- Product name
- 4-(2-Hydroxyethyl)benzoic acid
- Packaging
- 1g
- Price
- $376
- Updated
- 2021/12/16
- Product number
- 2629-1-97
- Product name
- 4-(2-Hydroxyethyl)benzoic acid
- Packaging
- 250mg
- Price
- $189
- Updated
- 2021/12/16
- Product number
- X8079
- Product name
- 4-(2-Hydroxyethyl)benzoicacid
- Packaging
- 1g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- CHM0307687
- Product name
- 4-(2-HYDROXYETHYL)BENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.57
- Updated
- 2021/12/16
4-(2-hydroxyethyl)benzoic acid Chemical Properties,Usage,Production
Synthesis
46190-45-8
46112-46-3
General procedure for the synthesis of 4-(2-hydroxyethyl)benzoic acid from methyl 4-(2-hydroxyethyl)benzoate: sodium hydroxide (58 mg, 1.43 mmol) was added to a mixed solution of methanol (3 mL) and water (1 mL) of methyl 4-(2-hydroxyethyl)benzoate (174 mg, 0.96 mmol) at room temperature. The reaction mixture was stirred at room temperature for 48 hours. Upon completion of the reaction, water (5 mL) was added to dilute and extracted with ether (3 x 20 mL) to remove unreacted feedstock and by-products. The aqueous phase was acidified with a 1:1 hydrochloric acid solution to pH=1 and a white solid was precipitated. The solid was collected by filtration to afford 4-(2-hydroxyethyl)benzoic acid (158 mg, 100% yield), and the product could be used in the next reaction without further purification. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.97 (d, J = 8.4 Hz, 2H), 7.27 (d, J = 8.4 Hz, 2H), 3.83 (t, J = 6.3 Hz, 2H), 2.88 (t, J = 6.3 Hz, 2H).
References
[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 11, p. 2988 - 2998
[2] Journal of the American Chemical Society, 2006, vol. 128, # 50, p. 16020 - 16021
4-(2-hydroxyethyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-(2-hydroxyethyl)benzoic acid Suppliers
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- United Kingdom
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View Lastest Price from 4-(2-hydroxyethyl)benzoic acid manufacturers
- Product
- 4-(2-Hydroxyethyl)benzoic acid 46112-46-3
- Price
- US $900.00/g
- Min. Order
- 1g
- Purity
- 97
- Supply Ability
- 5 Kg
- Release date
- 2024-02-12