8-Chloroisoquinoline
- Product Name
- 8-Chloroisoquinoline
- CAS No.
- 34784-07-1
- Chemical Name
- 8-Chloroisoquinoline
- Synonyms
- 8-Chloroisoquinoline;Isoquinoline, 8-chloro-;8-Chloroisoquinoline95%;8-Chloroisoquinoline 95%;8-Chloro-2-azanaphthalene;8-Chloroisoquinoline ISO 9001：2015 REACH
- CBNumber
- CB8958240
- Molecular Formula
- C9H6ClN
- Formula Weight
- 163.6
- MOL File
- 34784-07-1.mol
8-Chloroisoquinoline Property
- Melting point:
- 55.5-56.5 °C
- Boiling point:
- 289.5±13.0 °C(Predicted)
- Density
- 1.270±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.63±0.23(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C9H6ClN/c10-9-3-1-2-7-4-5-11-6-8(7)9/h1-6H
- InChIKey
- OXAMVYYZTULFIB-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=CC=C2Cl)C=CN=1
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C367405
- Product name
- 8-Chloroisoquinoline
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR8557
- Product name
- 8-Chloroisoquinoline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 3H32-5-K2
- Product name
- 8-Chloroisoquinoline
- Purity
- 95.0%
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FC20243
- Product name
- 8-Chloroisoquinoline
- Packaging
- 250mg
- Price
- $92.5
- Updated
- 2021/12/16
- Product number
- Y5393
- Product name
- 8-Chloroisoquinoline
- Packaging
- 5g
- Price
- $121
- Updated
- 2021/12/16
8-Chloroisoquinoline Chemical Properties,Usage,Production
Uses
Substituted isoquinoline.
Synthesis
956003-79-5
34784-07-1
General procedure for the synthesis of 8-chloroisoquinoline from 5-bromo-8-chloroisoquinoline: 5-bromo-8-chloroisoquinoline (1.20 g, 4.95 mmol, 1.0 eq.), 2-methyltetrahydrofuran (10 mL), and methanol (10 mL) were added to a single-necked glass flask, and then passed through nitrogen for degassing. Under an inert atmosphere, 10% palladium/carbon catalyst (530 mg, 0.5 mmol, 0.1 eq.) was added, followed by slow addition of sodium borohydride (206 mg, 5.45 mmol, 1.1 eq.). The flask was sealed with a gas bubbler filled with silicone oil. The mixture was stirred at 25 °C for 70 min (prolonged reaction time leads to the formation of excess by-products such as 1,2,3,4-tetrahydro-diisoquinoline and 8-chloro-1,2,3,4-tetrahydroisoquinoline) before the reaction was quenched with glacial acetic acid (500 μL, 8.74 mmol, 1.75 equiv). After continued stirring for 10 min, the reaction mixture was filtered through diatomaceous earth. The filter cake was washed with methanol and dichloromethane. The filtrate was concentrated and the residue was purified by fast column chromatography (silica gel, hexane-ethyl acetate, 93:7) to give an off-white crystalline product. Yield: 360 mg (44%); melting point 50-55 °C. IR (ATR): 1620, 1553, 1429, 1379, 1300, 1204, 1038, 970, 827, 748, 686, 634, 534 cm^-1. 1H NMR (400 MHz, CDCl3): δ = 9.66 (s, 1H). 8.60 (d, J=5.7Hz, 1H), 7.73 (d, J=7.9Hz, 1H), 7.69-7.56 (m, 3H).13C NMR (100MHz, CDCl3): δ=149.4, 143.8, 137.1, 132.5, 130.3, 127.5, 125.6, 125.7, 120.1 .
References
[1] Synthesis (Germany), 2018, vol. 50, # 11, p. 2181 - 2190
8-Chloroisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
8-Chloroisoquinoline Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
- Tel
- --
- Fax
- --
- info@manchesterorganics.com
- Country
- United Kingdom
- ProdList
- 6834
- Advantage
- 67
View Lastest Price from 8-Chloroisoquinoline manufacturers
- Product
- 8-Chloroisoquinoline 34784-07-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
- Product
- 8-Chloroisoquinoline 34784-07-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-10