Boc-D-Azetidine-2-carboxylic acid

Product Name: Boc-D-Azetidine-2-carboxylic acid
CAS No.: 228857-58-7
Chemical Name: Boc-D-Azetidine-2-carboxylic acid
Synonyms: Boc-D-Aze-OH;(R)-1-Boc-azetidine-2-car...;(R)-N-Boc-azetodome carboxylic;Boc-D-Azetidine-2-carboxylic acid;N-Boc-R-2-Azetidinecarboxylic acid;1-Boc-D-azetidine-2-carboxylic acid;Boc-(R)-azetidine-2-carboxylic acid;(R)-N-Boc-azetidine carboxylic acid;(R)-1-Boc-azetidine-2-carboxylic acid;(R)-N-Boc-azetidine-2-carboxylic Acid,99%e.e.
CBNumber: CB8966476
Molecular Formula: C9H15NO4
Formula Weight: 201.22
MOL File: 228857-58-7.mol

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Boc-D-Azetidine-2-carboxylic acid Property

Boiling point:: 321.0±35.0 °C(Predicted)
Density: 1.246
storage temp.: 2-8°C
pka: 4.01±0.20(Predicted)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A812565
Product name: 1,2-AzetidinedicarboxylicAcid1-(1,1-Dimethylethyl)Ester
Packaging: 2.5g
Price: $1260
Updated: 2021/12/16

Apolloscientific

Product number: OR309021
Product name: (R)-Azetidine-1,2-dicarboxylicacid1-tert-butylester
Purity: 98+%
Packaging: 10g
Price: $638
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 38335
Product name: (R)-1-(tert-Butoxycarbonyl)azetidine-2-carboxylicacid
Purity: 95+%
Packaging: 5G
Price: $750
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-03
Product name: (R)-N-Boc-Azetidinecarboxylic acid
Purity: 95%
Packaging: 5G
Price: $800
Updated: 2021/12/16

Activate Scientific

Product number: AS12115
Product name: (R)-N-Boc-Azetidine carboxylic acid
Purity: 97% ee
Packaging: 25g
Price: $917
Updated: 2021/12/16

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Boc-D-Azetidine-2-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

1,2-Azetidinedicarboxylic Acid 1-(1,1-Dimethylethyl) Ester, is an useful intermediate in the synthesis of pharmaceutical compounds including inhibitors and receptor Antagonists. It can be used in the synthesis of polypeptides.

Synthesis

24424-99-5

7729-30-8

228857-58-7

To a mixed solution of (R)-azetidine-2-carboxylic acid (20 g, 200 mmol), water (200 mL) and dioxane (200 mL) was slowly added dropwise a solution of di-tert-butyl dicarbonate (Boc2O) in dioxane (100 mL) at 0 °C. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 1 hour. After the reaction was complete, the mixture was concentrated and ether (200 mL) and water (200 mL) were added to the residue. The aqueous layer was acidified to pH 3-4 with 2N hydrochloric acid and then extracted with ethyl acetate (200 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated to give (R)-N-BOC-azetidine-2-carboxylic acid (40 g) in quantitative yield.LRMS (M-100 + H*) m/z 102.1.

References

[1] Patent: WO2008/16643, 2008, A2. Location in patent: Page/Page column 257
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 4, p. 407 - 412
[3] Patent: US6133253, 2000, A

Boc-D-Azetidine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-D-Azetidine-2-carboxylic acid Suppliers

China 119 India 1 United Kingdom 2 United States 9 Global 131

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
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Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
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Nanjing Habo Medical Technology Co., Ltd.

Tel: 025-85760892 13376080562
Fax: 025-85766769
Email: sales@habotech.com
Country: China
ProdList: 884
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Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
Fax: +86-21-34975602-805
Email: sales@bocpharma.com
Country: China
ProdList: 1009
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

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View Lastest Price from Boc-D-Azetidine-2-carboxylic acid manufacturers

Honest Joy Holdings Limited

Product: Boc-d-azetidine-2-carboxylic acid 228857-58-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.2%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: Boc-D-Azetidine-2-carboxylic acid 228857-58-7
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

228857-58-7, Boc-D-Azetidine-2-carboxylic acidRelated Search:

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(R)-Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester

(R)-1-Boc-azetidine-2-car...

1-Boc-D-azetidine-2-carboxylic acid

(R)-N-Boc-azetodome carboxylic

(R)-N-tert-Butoxycarbonylazetidine-2-carboxylic acid

(R)-1-(tert-butoxycarbonyl)azetidine-2-carboxylic acid

(R)-1-Boc-azetidine-2-carboxylic acid

Boc-(R)-azetidine-2-carboxylic acid

(2R)-1-tert-Butoxycarbonylazetidine-2-carboxylic acid

N-Boc-R-2-Azetidinecarboxylic acid

1,2-Azetidinedicarboxylicacid, 1-(1,1-diMethylethyl) ester, (2R)-

(2R)-1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-2-carboxylic acid

(R)-N-Boc-azetidine-2-carboxylic Acid,99%e.e.

Boc-D-Azetidine-2-carboxylic acid

(R)-N-Boc-azetidine carboxylic acid

(R)-Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester 98+%

Boc-D-Aze-OH

(2R)-1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-2-carb

(2R)-1-tert-Butoxycarbonylazetidine-2-carboxylic acid - [B0527]

228857-58-7

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