Rilmazafone

Product Name: Rilmazafone
CAS No.: 99593-25-6
Chemical Name: Rilmazafone
Synonyms: Rhythmy;450191-S;Rilmazafone;2',5-dichloro-2-(3-dimethylcarbamoyl-5-glycylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone;N,N-Dimethyl-1-[2-(2-chlorobenzoyl)-4-chlorophenyl]-5-(aminoacetylaminomethyl)-1H-1,2,4-triazole-3-carboxamide;5-((2-Aminoacetamido)methyl)-1-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide;5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide;5-[[(Aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide;5-[[(Aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N，N-dimethyl-1H-1，2，4-triazole-3-earboxamide;1H-1,2,4-Triazole-3-carboxamide, 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-
CBNumber: CB8969664
Molecular Formula: C21H20Cl2N6O3
Formula Weight: 475.33
MOL File: 99593-25-6.mol

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Rilmazafone Property

Density: 1.45±0.1 g/cm3(Predicted)
pka: 13.13±0.46(Predicted)
InChI: InChI=1S/C21H20Cl2N6O3/c1-28(2)21(32)20-26-17(11-25-18(30)10-24)29(27-20)16-8-7-12(22)9-14(16)19(31)13-5-3-4-6-15(13)23/h3-9H,10-11,24H2,1-2H3,(H,25,30)
InChIKey: KYHFRCPLIGODFH-UHFFFAOYSA-N
SMILES: N1(C2=CC=C(Cl)C=C2C(=O)C2=CC=CC=C2Cl)C(CNC(CN)=O)=NC(C(N(C)C)=O)=N1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0004071
Product name: RILMAZAFONE
Purity: 95.00%
Packaging: 1G
Price: $1725.15
Updated: 2021/12/16

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Rilmazafone Chemical Properties,Usage,Production

Description

Rilmazafone is known as one of the 'Japanese benzos' because it was first developed in Japan. It is a substituted heterocyclic 1,2,4 triazole of the class triazolyl benzophenones.
Rilmazafone is considered to be a benzodiazepine pro-drug, and in Japan, is used for the short-term treatment of insomnia. Benzodiazepines are scheduled as Prescription Medicines in Schedule 1 of the Medicines Regulations 1984. However, rilmazafone is itself not a benzodiazepine.

Uses

Rilmazafone is a water-soluble benzodiazepine prodrug that acts as a sedative and hypnotic neuropsychiatric agent.
Nishino et al (2008) examined the anxiolytic effect of short-acting benzodiazepine hypnotics, including rilmazafone, in mice using an elevated plus-maze. They concluded that these were more potent, with smaller doses, than diazepam used as a control.
Rilmazafone has been considered to have a high potential to influence performance in the equine athlete (Kentucky Horse Racing Commission, 2015).
Classification of Rilmazafone

Definition

ChEBI: Rilmazafone is a member of benzophenones.

Pharmacology

Rilmafazone belongs to a group of open-ring benzodiazepinone analogs called peptide aminobenzophenones.It appears to be a precursor of the triazolobenzodiazepinones.It has both sedative and antianxiety effects.

Synthesis

Rilmafazone is prepared from 2,5-dichloro-2-aminobenzophenone as described in below:

Metabolism

Rilmazafone is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives.
Rilmazafone, were suggested to have more beneficial pharmacolog-ical properties in comparison to standard benzodiazepines.Rilmazafone is a ring-opened derivative of 1,4-benzodiazepine (Scheme 12.28) and was developed inJapan as an orally active sleep inducer.

Rilmazafone is exclusively metabolized byaminopeptidases in the small intestine to the labile desglycylated metabolite 173and then to its cyclic form 174.The concentration of 174 in the systemic plasma (i.e., bioavailability) after oral administration of rilmazafone has been reported to behigher than that observed after administration of 174 due to the lower hepatic extrac-tion of 173 than 174.

Rilmazafone Preparation Products And Raw materials

Raw materials

FTHALIDE Methylamine

Preparation Products

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Rilmazafone Suppliers

China 21 Europe 2 Germany 1 United States 5 Global 29

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View Lastest Price from Rilmazafone manufacturers

Dorne Chemical Technology co. LTD

Product: Rilmazafone 99593-25-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

Hong Kong Excellence Biotechnology Co., Ltd.

Product: Rilmazafone 99593-25-6
Price: US $150.00-140.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 50000000
Release date: 2023-10-12

ZHEJIANG JIUZHOU CHEM CO., LTD

Product: Rilmazafone 99593-25-6
Price: US $558.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2023-01-30

99593-25-6, RilmazafoneRelated Search:

Linocaine hydrochloride Rilmazafone Hydrochloride 2-amino-2'-chlorobenzophenone 2-Amino-2',5-dichlorobenzophenone 1-Methyl-1H-1,2,4-triazole-5-methanamine (2-CHLOROPHENYL)(3-CHLOROPHENYL)METHANONE Rilmazafone 2-[1,2,4]TRIAZOL-1-YL-BENZALDEHYDE

Rilmazafone

5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide

450191-S

5-[[(Aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N，N-dimethyl-1H-1，2，4-triazole-3-earboxamide

5-[[(Aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide

N,N-Dimethyl-1-[2-(2-chlorobenzoyl)-4-chlorophenyl]-5-(aminoacetylaminomethyl)-1H-1,2,4-triazole-3-carboxamide

Rhythmy

2',5-dichloro-2-(3-dimethylcarbamoyl-5-glycylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone

1H-1,2,4-Triazole-3-carboxamide, 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-

5-((2-Aminoacetamido)methyl)-1-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide

99593-25-6

99593-29-6

C21H20Cl2N6O3

99593-25-6