ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
- Product Name
- ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
- CAS No.
- 850649-61-5
- Chemical Name
- ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
- Synonyms
- Alogliptin;Trajenta;Alogliptin (SYR-322);ALOGLIPTINA;Axagliptin hydrate;ogL;Agelieting;ALOGLIPTINE;Alogliptin,98%;Unii-jhc049lo86
- CBNumber
- CB91011068
- Molecular Formula
- C18H21N5O2
- Formula Weight
- 339.39
- MOL File
- 850649-61-5.mol
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Property
- Melting point:
- 127 - 129°C
- Boiling point:
- 519.2±60.0 °C(Predicted)
- Density
- 1.342
- Flash point:
- 267.8℃
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.89±0.20(Predicted)
- color
- White to Off-White
Safety
- Safety Statements
- 24/25
- RIDADR
- 3077
- HS Code
- 29335990
- Hazardous Substances Data
- 850649-61-5(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A575425
- Product name
- Alogliptin
- Packaging
- 100mg
- Price
- $325
- Updated
- 2021/12/16
- Product number
- FA17319
- Product name
- Alogliptin
- Packaging
- 250mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- P000456262
- Product name
- Alogliptin
- Purity
- 98+%
- Packaging
- 5g
- Price
- $426
- Updated
- 2021/12/16
- Product number
- A4038
- Product name
- Alogliptin(SYR-322)
- Packaging
- 100mg
- Price
- $470
- Updated
- 2021/12/16
- Product number
- orb134884
- Product name
- Alogliptin
- Purity
- >99%
- Packaging
- 100mg
- Price
- $510
- Updated
- 2021/12/16
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Chemical Properties,Usage,Production
Description
Alogliptin is a dipeptidyl-peptidase IV (DPP-4) inhibitor that was approved in Japan in 2010 for treatment of type 2 diabetes, a disease in which insulin resistance and β-cell dysfunction lead to hyperglycemia. As islet function is lost, the severity of insulin resistance increases. The introduction of DPP-4 inhibitors has brought a novel class of insulinotropic agents for the treatment options available to type 2 diabetic patients. The therapeutic potential of glucagon-like peptide 1 (GLP-1), an incretin peptide, for the treatment of type 2 diabetes was realized in the 1990s. The insulinotropic effects of GLP-1 depend closely on glucose concentrations providing the possibility of glucose normalization without the risk of hypoglycemia. GLP-1 has other non-insulinotropic physiological actions that are advantageous. It suppresses glucagon secretion from a cells and slows gastric emptying, which contributes to satiety and to a slower passage and reabsorption of carbohydrates. GLP-1 also contributes to satiety via a central mechanism as a neurotransmitter with effects on the hypothalamus.
Chemical Properties
White Solid
Originator
Syrrx Inc. (now Takeda San Diego) (Japan)
Uses
Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.
Definition
ChEBI: A piperidine that is 3-methyl-2,4-dioxo-3,4-dihydropyrimidine carrying additional 2-cyanobenzyl and 3-aminopiperidin-1-yl groups at positions 1 and 2 respectively (the R-enantiomer). Used in the form of its benzoate salt for treatment of t pe 2 diabetes.
brand name
Nesina
Clinical Use
Dipeptidyl peptidase 4 inhibitor:
Treatment of type 2 diabetes in combination with
other therapies
target
DPP-4
Metabolism
Alogliptin does not undergo extensive metabolism. Two minor metabolites were detected following administration of an oral dose of [14C]-alogliptin, N-demethylated alogliptin, M-I (<1% of the parent compound), and N-acetylated alogliptin, M-II (<6% of the parent compound). M-I is an active metabolite and is a highly selective inhibitor of DPP-4 similar to alogliptin; M-II does not display any inhibitory activity towards DPP-4 or other DPP-related enzymes. In vitro data indicate that CYP2D6 and CYP3A4 contribute to the limited metabolism of alogliptin.
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Preparation Products And Raw materials
Raw materials
Preparation Products
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
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- United Kingdom
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- Advantage
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- United Kingdom
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- Country
- United Kingdom
- ProdList
- 248
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View Lastest Price from ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) manufacturers
- Product
- ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) 850649-61-5
- Price
- US $0.00-0.00/g
- Min. Order
- 10000g
- Purity
- 99% HPLC
- Supply Ability
- 1000kg
- Release date
- 2024-11-20
- Product
- ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) 850649-61-5
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-12-02
- Product
- Alogliptin 850649-61-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%，single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2024-01-04