ChemicalBook > CAS DataBase List > DL-THREONINE METHYL ESTER HYDROCHLORIDE

DL-THREONINE METHYL ESTER HYDROCHLORIDE

Product Name
DL-THREONINE METHYL ESTER HYDROCHLORIDE
CAS No.
62076-66-8
Chemical Name
DL-THREONINE METHYL ESTER HYDROCHLORIDE
Synonyms
methyl 2-amino-3-hydroxybutanoate;Methyl 2-aMino-3-hydroxybutanoate hydrochloride;3-NO2-Tyr-OH;H-DL-Thr-OMe.HCl;DL-THREONINE METHYL ESTER HYDROCHLORIDE;Threonine,methyl ester, hydrochloride (1:1);DL-THREONINE METHYL ESTER HYDROCHLORIDE USP/EP/BP
CBNumber
CB9101261
Molecular Formula
C5H12ClNO3
Formula Weight
169.61
MOL File
62076-66-8.mol
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DL-THREONINE METHYL ESTER HYDROCHLORIDE Property

Melting point:
125℃
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
solid
color 
Beige
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Safety

WGK Germany 
3
HS Code 
2922500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S765430
Product name
DL-THREONINE METHYL ESTER HYDROCHLORIDE
Purity
AldrichCPR
Packaging
50mg
Price
$28.6
Updated
2022/05/15
TRC
Product number
T405555
Product name
DL-THREONINE METHYL ESTER HYDROCHLORIDE
Packaging
250mg
Price
$55
Updated
2021/12/16
Activate Scientific
Product number
AS42929-rac
Product name
Methyl 2-amino-3-hydroxybutanoate hydrochloride
Purity
97+%
Packaging
1g
Price
$32
Updated
2021/12/16
ChemScene
Product number
CS-W022797
Product name
Methyl2-amino-3-hydroxybutanoatehydrochloride
Packaging
10g
Price
$50
Updated
2021/12/16
Apolloscientific
Product number
OR928456
Product name
DL-THREONINE METHYL ESTER HYDROCHLORIDE
Purity
97%
Packaging
100g
Price
$493
Updated
2021/12/16
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DL-THREONINE METHYL ESTER HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Dl-threonine methyl ester HCl

Synthesis

67-56-1

28954-12-3

39994-75-7

The general procedure for the synthesis of L-threonine methyl ester hydrochloride from methanol and (2S,3S)-2-amino-3-hydroxybutanoic acid was as follows: a mixture of (2S,3S)-2-amino-3-hydroxybutanoic acid (5.4 g, 24.6 mmol) and 6N HCl (60 mL) was refluxed for 5 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was extracted with ether (3 x 70 mL) to remove the benzoic acid. The aqueous phase was concentrated to dryness under reduced pressure and the residue was further dried under high vacuum overnight to give crude allo-L-threonine. Methanol (25 mL) was cooled to 0 °C and thionyl chloride (1.80 mL, 25.2 mmol) was added slowly and dropwise. Crude allo-L-threonine was added to the resulting HCl methanol solution and the reaction mixture was heated to reflux for 1 hour. After completion of the reaction, the solvent was removed under vacuum and another batch of HCl methanol solution prepared in the same manner was added and again heated to reflux for 1 hour. Finally, the solvent was removed in vacuum to give allo-L-threonine methyl ester hydrochloride (4.15 g, 98% overall yield in two steps) as a red solid. The product was confirmed by 1H NMR (300 MHz, CD3OD): δ1.27 (d, J=6.6 Hz, 3H), 4.03 (d, J=3.3 Hz, 1H), 4.27-4.33 (m, 1H); 13C NMR (75 MHz, CD3OD): δ17.13,58.17,65.11,167.62; MS ( ESI, positive): m/z 134 [M+H]+.

References

[1] Journal of Organic Chemistry, 2002, vol. 67, # 5, p. 1536 - 1547
[2] Helvetica Chimica Acta, 1957, vol. 40, p. 1531,1544
[3] Journal of Organic Chemistry, 1997, vol. 62, # 21, p. 7364 - 7375
[4] Journal of Organic Chemistry, 2003, vol. 68, # 26, p. 10046 - 10057
[5] Journal of the American Chemical Society, 2007, vol. 129, # 18, p. 6017 - 6021

DL-THREONINE METHYL ESTER HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DL-THREONINE METHYL ESTER HYDROCHLORIDE Suppliers

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View Lastest Price from DL-THREONINE METHYL ESTER HYDROCHLORIDE manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
DL-Thr-Ome.HCl 62076-66-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-04-08
Career Henan Chemical Co
Product
DL-THREONINE METHYL ESTER HYDROCHLORIDE 62076-66-8
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2020-01-08

62076-66-8, DL-THREONINE METHYL ESTER HYDROCHLORIDERelated Search:

H-D-THR-OME HCL DL-Threonine Methyl L-threoninate hydrochloride H-THR-OTBU HCL L-THREONINE ETHYL ESTER HYDROCHLORIDE H-THR(TBU)-OTBU HCL H-THR(TBU)-ALLYL ESTER HCL ETHYL-D-ERYTHRO-SPHINGOSINATE HYDROCHLORIDE H-ALLO-THR-OME HCL DL-THREONINE METHYL ESTER HYDROCHLORIDE ethyl DL-threoninate hydrochloride H-THR(TBU)-OME HCL H-D-ALLO-THR-OME HCL H-D-THR(TBU)-OME HCL SYRINGOMYCIN E FROM PSEUDOMONAS SYRINGAE B-301D D-THREONINE BENZYL ESTER HYDROCHLORIDE 2-AMINO-3-HYDROXY-3-PHENYL-PROPIONIC ACID ETHYL ESTER HYDROCHLORIDE L-THREONINE METHYL ESTER

  • DL-THREONINE METHYL ESTER HYDROCHLORIDE
  • H-DL-Thr-OMe.HCl
  • Methyl 2-aMino-3-hydroxybutanoate hydrochloride
  • 3-NO2-Tyr-OH
  • Threonine,methyl ester, hydrochloride (1:1)
  • methyl 2-amino-3-hydroxybutanoate
  • DL-THREONINE METHYL ESTER HYDROCHLORIDE USP/EP/BP
  • 62076-66-8
  • C5H12ClNO3
  • Modified Amino Acids
  • I - Z
  • BioChemical
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • Amino Acids
  • I - Z
  • Modified Amino Acids